Activin Receptor Type IIB (ACVR2B) is a transmembrane serine/threonine kinase that forms an activin receptor complex with type I receptors. It functions as the primary receptor for activin-A, activin-B, and inhibin-A, regulating diverse processes including neuronal differentiation/survival, hair follicle cycling, pituitary FSH production, wound healing, extracellular matrix formation, immunosuppression and carcinogenesis. Upon activation, ACVR2B phosphorylates type I receptors to initiate SMAD2/SMAD3-SMAD4-mediated transcriptional regulation.
- Derived from rabbit host
- Reacts with human, mouse, and rat samples
- Non-conjugated
- SwissProt ID: Q13705
- Research field: Signal Transduction
- Liquid appearance
- Application: WB (1:500-1:1000 dilution)
- Storage at -20°C for 1 year; avoid repeated freeze/thaw cycles