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Aromatic organic compounds that consist of a phenyl functional group (−C6H5) bonded to a hydroxyl functional group (−OH). Includes compounds with more substitutions and derivatives.
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P-CAB agent 2 hydrochloride is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. It inhibits H+/K+-ATPase activity with an IC50 value of <100 nM. It also inhibits the hERG potassium channel with an IC50 value of 18.69 μM. This compound shows no acute toxicity and inhibits histamine-induced gastric acid secretion.
Potent and orally active potassium-competitive acid blocker
Gastric acid secretion inhibitor
Inhibits H+/K+-ATPase activity with an IC50 value of <100 nM
Inhibits the hERG potassium channel with an IC50 value of 18.69 μM
Shows no acute toxicity
Inhibits histamine-induced gastric acid secretion
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P-selectin is a Ca(2 )-dependent receptor on myeloid cells that critically binds to sialic acid-Lewis X on neutrophils and monocytes promoting the interaction between activated endothelial cells or platelets and leukocytes interaction This binding primarily to SELPLG/PSGL1 and PODXL2 is critical for rapid rolling of leukocytes during early inflammation P-Selectin Protein Human (HEK293 Fc) is the recombinant human-derived P-Selectin protein expressed by HEK293 with C-hFc labeled tag
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