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Organic compounds that contain a carboxyl group bonded to an organic functional group; carboxyl groups consist of a carbonyl group bonded to a hydroxy group. Includes compounds that are derived from carboxylic acids.
Uridine 5 -monophosphate disodium salt (CAS No 3387-36-8) is a nucleotide derivative frequently utilized in biochemical and pharmaceutical research It acts within the pyrimidine metabolism pathway and is a precursor to RNA synthesis playing a crucial role in cellular proliferation and differentiation Its in vitro activity is typically observed in the nanomolar to low micromolar range offering significant potential in research related to neuroprotection and cognitive enhancement This compound is often employed in various models including cell cultures and animal studies to investigate its effects on brain metabolism and functional recovery It is also used in drug screening assays aimed at identifying neuroprotective agents Experimental concentrations typically depend on the specific research design allowing flexibility in dosages based on the nature and objectives of individual studies
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Phosphoramidon Disodium Salt is a metalloendopeptidase inhibitor widely used as a biochemical tool Phosphoramidon inhibited ECE NEP and ACE activities with IC50 values of 3 5 M 0 034 M and 78 M respectively
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Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. 1. Sesamolin and Sesamin has neuroprotective effect. 2. Sesamolin protects microglia against H2O2-induced cell injury by inhibiting of p38 MAPK and caspase-3 activation and ROS production. 3. Sesamolin and Sesamin can significantly attenuate the excess generation of nitric oxide in lipopolysaccharide-stimulated rat primary microglia cells. purity: 98%
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DG013A is a phosphinic acid tripeptide mimetic inhibitor used for research related to autoimmune disease and cancer. It exhibits significantly weak affinity for both ERAP1 (IC50 = 33 nM) and ERAP2 (IC50 = 11 nM).
Phosphinic acid tripeptide mimetic inhibitor
Exhibits weak affinity for ERAP1 (IC50 = 33 nM)
Exhibits weak affinity for ERAP2 (IC50 = 11 nM)
Suitable for research into autoimmune disease and cancer
For research use only
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Concanavalin A (Con A) derived from Canavalia ensiformis (jack bean) is a plant lectin protein (Mw 104 kDa) Under pH 7 0 Con A exists as a homotetramer composed of four subunits of 26 kDa each Under pH 4 5-5 5 Con A dissociates into active dimers (52 kDa) Acetylation succinylation or other chemical modifications can also produce stable dimeric forms Each subunit is capable of binding one Ca2 and one Mn2 and contains a carbohydrate-binding site After binding metal ions Con A can specifically bind to glycoproteins glycolipids and carbohydrate moieties containing -D-glucose and -D-mannose It is used for carbohydrate analysis glycoprotein purification enzyme tagging cell membrane studies cell agglutination assays cell cultures and cell typing This product is a ready-to-use aqueous buffered solution (500X concentrate) of Con A and serves as an exogenous lectin suitable for use as a potent leukocyte mitogen
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Also available in 5 mg 10 mg 25 mg 50 mg 200 mg and bulk. Please contact Fisher for quotes. Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite a bile acid which inhibits radioligand binding to muscarinic M1 but not to M2 or M3 receptors. purity: 99%
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POPG sodium salt is a negatively charged phospholipid that influences membrane protein interactions by altering the charge characteristics of the lipid environment. It has applications in Parkinson's disease research and can be used in the creation of nanoparticles for co-encapsulating and releasing hydrophilic peptide compounds.
Increases apparent affinity of Gαq and Gβ1γ1 for activated NTS1
Interacts with the positive charge of peptides
Used in Parkinson's disease research
Utilized for creating nanoparticles for co-encapsulating and releasing hydrophilic peptide compounds
Enhances the binding of peptides like PAP248-286 in membranes
Bilayers can be penetrated by antimicrobial peptides such as LL-37
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