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Organic compounds that contain a carboxyl group bonded to an organic functional group; carboxyl groups consist of a carbonyl group bonded to a hydroxy group. Includes compounds that are derived from carboxylic acids.
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Boc-NH-PEG2-CH2COOH is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are designed with two different ligands connected by a linker; one binds to an E3 ubiquitin ligase and the other to the target protein, enabling the selective degradation of target proteins through the intracellular ubiquitin-proteasome system.
Peg-based protac linker
Used in the synthesis of protacs
Enables selective degradation of target proteins
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Iodoacetamide-PEG3-azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This click chemistry reagent features an Azide group that facilitates copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with Alkyne-containing molecules. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
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Amino-PEG3-CH2COOH is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting an E3 ubiquitin ligase ligand to a target protein ligand via a linker.
PEG-based PROTAC linker
Used in the synthesis of PROTACs
Exploits the ubiquitin-proteasome system
Selectively degrades target proteins
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More