Azoles
Apexbio Technology LLC Cytochrome c fragment (93-108) 25mg
Cytochrome c fragment 93-108 is a peptide derived from cytochrome c a mitochondrial protein involved in apoptosis It is designed to interact with apoptotic protease activating factor-1 (Apaf-1) thereby promoting the assembly of the Apaf-1/caspase-9 apoptosome complex and regulating the caspase activation pathway Cytochrome c fragment 93-108 exerts its biological activity primarily through activation of the caspase cascade specifically the activation of caspase-9 and subsequent caspase-3 Based on these pharmacological properties cytochrome c fragment 93-108 holds research potential in studies of apoptosis-related signaling networks caspase activation pathways and drug screening targeting apoptosis regulators
(C)OCCI | 1g | 249361749](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000216492.jpg-250.jpg)
eMolecules 101166-65-8 | tert-Butyl(2-iodoethoxy)dimethylsilane | Combi-Blocks | MFCD09909940 | 286.228 | C8H19IOSi | 98.000 | CC(C)(C)[Si](C)(C)OCCI | 1g | 249361749
tert-Butyl(2-iodoethoxy)dimethylsilane | Combi-Blocks | 101166-65-8 | MFCD09909940 | 286.228 | C8H19IOSi | 98.000 | CC(C)(C)[Si](C)(C)OCCI | 1g | 249361749
Medchemexpress LLC Octanoic acid, 8-bromo-, 1-octylnonyl ester | 2089253-22-3 | MFCD34178802 | 97.0% | 461.56 g/mol | C25H49BrO2 | 50 MG
Heptadecan-9-yl 8-bromooctanoate is a brominated lipid ester supplied for research use as a hydrophobic building block for lipid nanoparticles (LNPs) and related lipid formulations. It is used in lipid chemistry and formulation development to introduce a brominated alkyl chain for downstream modification and formulation studies.
- Brominated lipid ester for LNP construction.
- Useful as a hydrophobic building block in lipid formulations.
- Chemical formula C25H49BrO2; molecular weight 461.56 g/mol.
- CAS number 2089253-22-3 for unambiguous identification.
- Purity 97.0% as supplied.
- Storage: pure form -20°C up to 3 years; in solvent -80°C (6 months) or -20°C (1 month).
- Available in multiple pack sizes including solution and solid forms.
Medchemexpress LLC OF-02 | 1883431-67-1 | ≥98.0% | C84H152N4O6 | 25 MG
OF-02 is an ionizable lipid essential for mRNA delivery, serving as a key component of lipid nanoparticles (LNPs). It becomes protonated in acidic endosomal environments, which aids in the escape of mRNA and effective protein expression in target cells. The lipid's pH-responsive membrane fusion properties allow it to complex with mRNA, disrupt endosomal membrane structures, and facilitate mRNA release into the cytoplasm.
- Ionizable lipid for mRNA delivery
- Key component of lipid nanoparticles (LNPs)
- Promotes endosomal escape of mRNA
- Induces protein expression in target cells
- Utilizes pH-responsive membrane fusion properties
- Enables mRNA release into the cytoplasm
- Used in mRNA vaccine development
- Used in gene editing applications
- Used in protein replacement therapy
eMolecules 57159-62-3 | 2,5-dioxopyrrolidin-1-yl 3-(2-bromoacetamido)propanoate | Abosyn Chemicals Inc. | MFCD01863457 | 307.100 | C9H11BrN2O5 | 0.000 | BrCC(=O)NCCC(=O)ON1C(=O)CCC1=O | 5g | 795353934
2,5-dioxopyrrolidin-1-yl 3-(2-bromoacetamido)propanoate | Abosyn Chemicals Inc. | 57159-62-3 | MFCD01863457 | 307.100 | C9H11BrN2O5 | 0.000 | BrCC(=O)NCCC(=O)ON1C(=O)CCC1=O | 5g | 795353934
Medchemexpress LLC (E)-5-fluoro-N-(3-(3-(hydroxyamino)-3-oxoprop-1-en-1-yl)-4-methoxybenzyl)-2-morpholinoben | 3031349-25-1 | 95.0% | 429.44 | 25 MG
This potent HDAC inhibitor demonstrates IC50s for HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8, and inhibits cell migration and invasion. It induces apoptosis and cell cycle arrest at the G2/M phase, also showing anti-tumor activity.
- Potent inhibition of HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8.
- Inhibits cell migration and invasion, and induces apoptosis and cell cycle arrest at G2/M phase.
- Demonstrates anti-tumor activity.
- Inhibits tubulin polymerization.
- Increases expression of acetylated-α-tubulin and acetyl-histone H3.
- Modulates mitochondrial membrane potential and reactive oxygen species levels.
- Exhibits favorable liver microsomal stability.
- Shows antiproliferative activities in various cancer cell lines.
- Demonstrates antivascular activity and good cardiovascular safety in vivo.
- Reduces tumor weights in allograft mouse models.