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Organic compounds that consist of a benzene ring substituted with amino and carboxyl groups. Includes compounds that are derived from aminobenzoic acids.
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
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Nafamostat (CAS 81525-10-2) is a small-molecule inhibitor targeting a broad spectrum of serine proteases including thrombin plasmin kallikrein and human trypsin It is designed to block protease-mediated hydrolysis reactions thereby regulating coagulation pathways and inflammation-related protease activity Nafamostat exerts its biological activity primarily through reversible binding to protease active sites inhibiting their enzymatic functions In biochemical assays Nafamostat demonstrates potent inhibitory activity with an IC50 value of approximately 1 10 nM against human trypsin Based on these pharmacological properties Nafamostat holds research potential in coagulation pathway studies inflammation-related protease research pancreatitis modeling and mechanistic investigations of blood coagulation disorders and inflammatory responses
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Nafamostat (CAS 81525-10-2) is a small-molecule inhibitor targeting a broad spectrum of serine proteases including thrombin plasmin kallikrein and human trypsin It is designed to block protease-mediated hydrolysis reactions thereby regulating coagulation pathways and inflammation-related protease activity Nafamostat exerts its biological activity primarily through reversible binding to protease active sites inhibiting their enzymatic functions In biochemical assays Nafamostat demonstrates potent inhibitory activity with an IC50 value of approximately 1 10 nM against human trypsin Based on these pharmacological properties Nafamostat holds research potential in coagulation pathway studies inflammation-related protease research pancreatitis modeling and mechanistic investigations of blood coagulation disorders and inflammatory responses
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Calyculin A is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC50s of 2 nM and 0.5-1 nM, respectively. It is for research use only.
Potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor.
Induces cytotoxicity in MG63 cells in a dose-dependent manner.
Cited in 19 publications on Google Scholar.
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Nafamostat formate salt-13C6 is the 13C labeled Nafamostat. Nafamostat is a synthetic serine protease inhibitor and an anticoagulant. It suppresses T cell auto-reactivity by decreasing granzyme activity and CTL cytolysis, and also blocks the activation of SARS-CoV-2.
13C labeled Nafamostat
Synthetic serine protease inhibitor
Anticoagulant
Suppresses T cell auto-reactivity
Decreases granzyme activity and CTL cytolysis
Blocks activation of SARS-CoV-2
Can be used as a tracer
Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
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α-Phellandrene (CAS 99-83-2) is a cyclic monoterpene (C10H16) found in plant essential oils and used as a research reagent. It has reported insecticidal activity and biological effects in apoptosis, autophagy, cAMP signaling, and inflammatory/cancer models.
Cyclic monoterpene with molecular formula C10H16 and molecular weight 136.23 g/mol.
Reported insecticidal and anti-inflammatory activities useful for biological studies.
Used in research on apoptosis, autophagy, and NO/cAMP signaling pathways.
Storage guidance: pure form -20°C (3 years), 4°C (2 years); in solvent -80°C (6 months), -20°C (1 month).
Available in small laboratory pack sizes suitable for research use.
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2-Amino-5-bromo-3-nitropyridine is a biochemical reagent intended for life science related research. It serves as a biological material or organic compound for various scientific applications.
Biochemical reagent
Suitable for life science research
Can be used as a biological material
Functions as an organic compound
For research use only
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2-Amino-4-bromo-3-nitropyridine is a drug intermediate primarily used for the synthesis of various active compounds. This product is intended for research use only and has not been fully validated for medical applications.
Used as a drug intermediate
Facilitates synthesis of various active compounds
Intended for research use only
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2-Amino-5-bromo-2′-fluorobenzophenone is a precursor in the synthesis of Flubromazepam. This chemical compound is intended for research use only and has not been fully validated for medical applications.
Precursor in the synthesis of Flubromazepam
Suitable for laboratory research
Available in various quantities
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