Benzenesulfonamides
eMolecules 1019331-10-2 | Medchem Express | S0859 | 5mg | 446265892 | HY-15529 | MFCD23136018 | 530.04 | C29H24ClN3O3S
Ambeed | 2-(5-(3-(4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid | 2mg | 534568417 | A515360 | 1030612-90-8 | MFCD20039622 | 467.255 | C17H16BrFN6O4
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Apexbio Technology LLC Bosentan Hydrate 157212-55-0 200mg
Bosentan Hydrate (CAS 157212-55-0) is a sulfonamide-derived competitive antagonist of endothelin receptors exhibiting preferential affinity toward endothelin A over endothelin B receptors By interfering with endothelin-triggered signaling in endothelial and vascular smooth muscle cells it attenuates vasoconstrictive and bronchoconstrictive responses In vitro studies revealed bosentan inhibited endothelin receptor activity in P388/dx cells (IC50 15 1 1 6 M) and effectively reversed antiangiogenic effects of systemic sclerosis patient sera on dermal microvascular endothelial cells In animal models bosentan administration post-myocardial infarction significantly elevated plasma leptin levels Clinically bosentan is applied extensively in research on pulmonary arterial hypertension showing beneficial outcomes on patients exercise capacity
Apexbio Technology LLC Bosentan Hydrate 157212-55-0 100mg
Bosentan Hydrate (CAS 157212-55-0) is a sulfonamide-derived competitive antagonist of endothelin receptors exhibiting preferential affinity toward endothelin A over endothelin B receptors By interfering with endothelin-triggered signaling in endothelial and vascular smooth muscle cells it attenuates vasoconstrictive and bronchoconstrictive responses In vitro studies revealed bosentan inhibited endothelin receptor activity in P388/dx cells (IC50 15 1 1 6 M) and effectively reversed antiangiogenic effects of systemic sclerosis patient sera on dermal microvascular endothelial cells In animal models bosentan administration post-myocardial infarction significantly elevated plasma leptin levels Clinically bosentan is applied extensively in research on pulmonary arterial hypertension showing beneficial outcomes on patients exercise capacity
Medchemexpress LLC Sildenafil N-oxide | 1094598-75-0 | MFCD22683784 | 100mg
Sildenafil Impurity 1 is an impurity of Sildenafil (HY-15025)
Medchemexpress LLC Sulfacetamide sodium monohydrate | 6209-17-2 | 99.5% | 25 G
Sulfacetamide sodium monohydrate is a sulfonamide antibiotic used for the study of ocular infections. It exhibits antifungal and antibacterial activities, acting as a bacteriostatic agent against both Gram-positive and Gram-negative bacteria. This compound is suitable for researching various ocular infections such as trachoma, blepharitis, conjunctivitis, corneal ulcer, pityriasis versicolor, and rosacea, and it functions as an antifungal drug via a CYP51A1-independent mechanism.
- Exhibits antifungal activity
- Exhibits antibacterial activity
- Acts as a bacteriostatic agent
- Effective against Gram-positive bacteria
- Effective against Gram-negative bacteria
- Used for studying ocular infections including trachoma, blepharitis, conjunctivitis, corneal ulcer, pityriasis versicolor, and rosacea
- Functions as an antifungal drug via a CYP51A1-independent mechanism
- For research use only
eMolecules 159182-43-1 | Medchem Express | L755507 | 5mg | 446269740 | HY-19334 | MFCD08703099 | 584.73 | C30H40N4O6S
Medchem Express | Elexacaftor | 1mg | 495799770 | HY-111772 | 2216712-66-0 | 597.660 | C26H34F3N7O4S
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Medchemexpress LLC HY-102033 1mg Medchemexpress, Oxamflatin CAS:151720-43-3 Purity:>98%
Medchemexpress, HY-102033 1mg Oxamflatin CAS:151720-43-3 Oxamflatin (Metacept-3) is a potent HDAC inhibitor with an IC50 of 15.7 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Sildenafil | 139755-83-2 | C22H30N6O4S | 1 G
Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM. It is intended for research use only.
- Potent PDE5 inhibitor
- IC50 of 5.22 nM against PDE5
- Potentiates ERK1/ERK2 phosphorylation
- Increases cell proliferation
- Increases intracavernosal pressure and ICP/blood pressure ratio in dog models
- Decreases the number of TL+-cells
- Reduces microglia/macrophages in pMCAo models
- Decreases flap necrosis in preclinical animal models
Medchemexpress LLC Clorsulon | 60200-06-8 | 99.99% | 100 MG
Clorsulon is an orally active flukicidal agent. It works by inhibiting glycolysis, the primary energy production pathway in flukes. It also acts as a competitive inhibitor of 3-phosphoglycolate and ATP, thereby inhibiting glucose utilization and the formation of acetate and propionate by mature *Fasciola hepatica* in vitro. It is used in studies of liver fluke (*Fasciola hepatica* and *Fasciola gigantica*) infection in calves and sheep.
- Inhibits glycolysis in flukes
- Competitive inhibitor of 3-phosphoglycolate and ATP
- Inhibits glucose utilization and formation of acetate and propionate by mature *Fasciola hepatica*
- Used in studies of liver fluke infection
eMolecules 133745-75-2 | N-Fluorobenzenesulfonimide | Chem-Impex | MFCD00144885 | 315.330 | C12H10FNO4S2 | 98.000 | FN(S(=O)(=O)c1ccccc1)S(=O)(=O)c1ccccc1 | 100g | 386904250
N-Fluorobenzenesulfonimide | Chem-Impex | 133745-75-2 | MFCD00144885 | 315.330 | C12H10FNO4S2 | 98.000 | FN(S(=O)(=O)c1ccccc1)S(=O)(=O)c1ccccc1 | 100g | 386904250
eMolecules 333745-53-2 | Medchem Express | LX2343 | 5mg | 446259989 | HY-111383 | 474.91 | C22H19ClN2O6S
Ambeed | 2367-Tetrahydrobenzo[12-b45-b]difuran | 10g | 552646143 | A206955 | 81926-24-1 | MFCD08436969 | 162.188 | C10H10O2
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Medchemexpress LLC YAP-TEAD-IN-1 TFA | 1659305-79-9 | 99.99% | 2133.88 | 10 MG
YAP-TEAD-IN-1 TFA is a potent and competitive peptide inhibitor of YAP-TEAD interaction (IC50=25 nM). This 17mer peptide demonstrates a higher binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd= 40 nM).
- Potent and competitive peptide inhibitor of YAP-TEAD interaction
- IC50 of 25 nM
- 17mer peptide
- Higher binding affinity to TEAD1 (Kd=15 nM)
- Active against endogenous YAP binding to GST-TEAD
- Targets YAP/TAZ
- Soluble in H2O at ≥ 50 mg/mL (23.43 mM)
Accela Chembio Inc N-cyclopropyl 4-nitrophenylsulfonamide | 25g | 549476-61-1 | MFCD00458256 | 97+% | Shelf Life: 2520 Days | Regular
N-cyclopropyl 4-nitrophenylsulfonamide | 25g | 549476-61-1 | MFCD00458256 | 97+% | Shelf Life: 2520 Days | Regular
Apexbio Technology LLC Bosentan 147536-97-8 200mg
Bosentan (CAS 147536-97-8) is a small molecule that acts as a competitive antagonist at both endothelin-A (ET-A) and endothelin-B (ET-B) receptors By blocking the binding of endothelin-1 to these receptors bosentan modulates endothelin-mediated vasoconstriction and cellular proliferation pathways This compound is utilized in biomedical research to investigate the endothelin signaling axis and its role in cardiovascular physiology pulmonary hypertension and related pathologies Bosentan enables the study of receptor-specific effects of endothelin-1 inhibition and offers a tool for evaluating therapeutic strategies targeting the endothelin system
Medchemexpress LLC Darunavir Ethanolate | 635728-49-3 | 99.9% | 593.73 | 100 MG
Darunavir ethanolate (TMC114 Ethanolate) is a potent HIV protease inhibitor used to treat and prevent HIV/AIDS. Darunavir has a Ki of 1 nM for wild type HIV-1 protease. It is for research use only and not sold to patients. Darunavir is effective against wild-type and PI-resistant HIV, and has an oral bioavailability of 37%. It needs to be combined with ritonavir, which increases the bioavailability to 82%.
- Potent HIV protease inhibitor
- Active against HIV-1 clinical isolates
- Forms hydrogen bonds with conserved main-chain atoms of Asp29 and Asp30 of the protease
- Greater potency than saquinavir, amprenavir, nelfinavir, indinavir, lopinavir, and ritonavir in an in vitro study
- Effective against wild-type and PI-resistant HIV
- Oral bioavailability increased to 82% when combined with ritonavir