Benzenesulfonamides
Apexbio Technology LLC Bosentan 147536-97-8 500mg
Bosentan (CAS 147536-97-8) is a small molecule that acts as a competitive antagonist at both endothelin-A (ET-A) and endothelin-B (ET-B) receptors By blocking the binding of endothelin-1 to these receptors bosentan modulates endothelin-mediated vasoconstriction and cellular proliferation pathways This compound is utilized in biomedical research to investigate the endothelin signaling axis and its role in cardiovascular physiology pulmonary hypertension and related pathologies Bosentan enables the study of receptor-specific effects of endothelin-1 inhibition and offers a tool for evaluating therapeutic strategies targeting the endothelin system
Medchemexpress LLC N-desmethyl sildenafil-d8 | 1185168-06-2 | MFCD11977920 | 99.3% | 468.60 g/mol | C21H20D8N6O4S | 5 MG
N-Desmethyl sildenafil-d8 is a deuterium-labeled analytical standard of the N-desmethyl metabolite of sildenafil, provided in milligram quantities for research and quantitative analysis. It is intended for use as an internal standard in mass-spectrometry, pharmacokinetic, and metabolic studies, and is supplied with recommended storage conditions to preserve isotopic integrity.
- Deuterium-labeled internal standard for quantitative LC-MS/MS analysis.
- High purity suitable for analytical and pharmacokinetic studies.
- Supplied in small milligram amounts for precise measurements.
- Stable under recommended storage to maintain isotopic composition.
- Appropriate as a reference material for metabolite identification.
Sigma Aldrich Fine Chemicals Biosciences Glibenclamide impurity A European Pharmacopoeia (EP) Reference Standard | 16673-34-0 | MFCD00193756 |
Glibenclamide impurity A European Pharmacopoeia (EP) Reference Standard | Mol Wt: 368.84 | 16673-34-0 | MFCD00193756 |
eMolecules 486422-57-5 | 4-(Pyrrolidinylsulfonyl)phenylboronic acid | Combi-Blocks | MFCD06659847 | 255.100 | C10H14BNO4S | 98.000 | OB(O)c1ccc(cc1)S(=O)(=O)N1CCCC1 | 1g | 117521167
4-(Pyrrolidinylsulfonyl)phenylboronic acid | Combi-Blocks | 486422-57-5 | MFCD06659847 | 255.100 | C10H14BNO4S | 98.000 | OB(O)c1ccc(cc1)S(=O)(=O)N1CCCC1 | 1g | 117521167
eMolecules 26103-51-5 | 3-(Pyrrolidin-1-ylsulfonyl)pyridine | Combi-Blocks | MFCD09258659 | 212.270 | C9H12N2O2S | 98.000 | O=S(=O)(N1CCCC1)c1cccnc1 | 1g | 117548284
3-(Pyrrolidin-1-ylsulfonyl)pyridine | Combi-Blocks | 26103-51-5 | MFCD09258659 | 212.270 | C9H12N2O2S | 98.000 | O=S(=O)(N1CCCC1)c1cccnc1 | 1g | 117548284
eMolecules 871266-63-6 | PCI-27483 | MFCD25976837 | 0.1g
AstaTech | PCI-27483 | 0.1g | 551677127 | 40610 | 95.000 | 871266-63-6 | MFCD25976837 | 596.570 | C26H24N6O9S
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eMolecules 151720-43-3 | Medchem Express | Oxamflatin | 1mg | 446257610 | HY-102033 | MFCD00949087 | 342.37 | C17H14N2O4S
ChemScene | 1-Methyl-1H-indole-6-carbonitrile | 1g | 791178640 | CS-0043605 | 20996-87-6 | MFCD08690254 | 156.188 | C10H8N2
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Medchemexpress LLC Sildenafil (citrate) | 171599-83-0 | C28H38N6O11S | 5 G
Sildenafil citrate is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM. It is intended for research use only.
- Potent phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 5.22 nM.
- Potentiates phosphorylation of ERK1/ERK2.
- Increases percentage of cells in S phase and cell proliferation.
- Enhances upregulation of ERK1/ERK2 phosphorylation induced by serotonin.
- Increases intracavernosal pressure (ICP) and ICP/BP in dog models.
- Reduces the number of TL+-cells and microglia/macrophages in ischemic models.
- Decreases flap necrosis by increasing growth factors (FGF and VEGF).
- Used in clinical trials for pulmonary arterial hypertension, erectile dysfunction, spinal cord injuries, pregnancy complication, cancer, and more.
Apexbio Technology LLC Glimepiride 93479-97-1 5g
Glimepiride (CAS 93479-97-1) is a sulfonylurea compound widely used in research on type 2 diabetes It primarily acts by enhancing glucose uptake both in the presence and absence of insulin In cultured cells glimepiride (10 M) increases 2-deoxyglucose uptake to 186% of control and upregulates GLUT1 and GLUT4 expression to 164% and 148% of control respectively indicating insulin-independent mechanisms for stimulating cardiac glucose uptake In rodent models glimepiride administration reduced diabetes incidence by 23% in BB rats and decreased blood glucose HbA1c and plasma insulin levels in KK-Ay mice highlighting its utility for investigating glucose metabolism and diabetes pathophysiology
Cayman Chemical Ndesmethyl Sildenafil citrat
A major metabolite of sildenafil; formed via oxidative metabolism of sildenafil by CYP3A4, CYP3A5, and CYP3A7
Medchemexpress LLC Deltasonamide 2 hydrochloride | 2448341-55-5 | 99.8% | 10MG
Deltasonamide 2 hydrochloride | 2448341-55-5 | 99.8% | 10MG
Sigma Aldrich Fine Chemicals Biosciences Sildenafil citrate United States Pharmacopeia (USP) Reference Standard | 171599-83-0 | MFCD09026931 | 100MG
Sildenafil citrate United States Pharmacopeia (USP) Reference Standard | Mol Wt: 666.7 | 171599-83-0 | MFCD09026931 | 100MG
eMolecules 1334950-73-0 | Ambeed | 1-(Phenylsulfonyl)-4-(4455-tetramethyl-132-dioxaborolan-2-yl)-1H-indole | 250mg | 728126188 | A1672659 | MFCD12828205 | 383.27 | C20H22BNO4S
ChemScene | 1H-Imidazole-2-carboxamide | 100mg | 582643980 | CS-0060699 | 16093-82-6 | MFCD09261275 | 111.104 | C4H5N3O
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Medchemexpress LLC HY-100892 5mg Medchemexpress, MX69 CAS:1005264-47-0 Purity:>98%
Medchemexpress, HY-100892 5mg MX69 CAS:1005264-47-0 MX69 is an inhibitor of MDM2/XIAP , used for cancer treatment. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
eMolecules 486422-58-6 | 4-(Piperidin-1-ylsulfonyl)phenylboronic acid | Combi-Blocks | MFCD06659850 | 269.120 | C11H16BNO4S | 98.000 | OB(O)c1ccc(cc1)S(=O)(=O)N1CCCCC1 | 1g | 117521176
4-(Piperidin-1-ylsulfonyl)phenylboronic acid | Combi-Blocks | 486422-58-6 | MFCD06659850 | 269.120 | C11H16BNO4S | 98.000 | OB(O)c1ccc(cc1)S(=O)(=O)N1CCCCC1 | 1g | 117521176