Benzenesulfonamides
Medchemexpress LLC Sildenafil (citrate) | 171599-83-0 | C28H38N6O11S | 10 G
Sildenafil citrate is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM. This compound is intended for research use only.
- Potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM.
- Increases the phosphorylation of ERK1/ERK2.
- Potentiates cell proliferation.
- Enhances the upregulation of ERK1/ERK2 phosphorylation induced by serotonin.
- Significantly increases intracavernosal pressure (ICP) and ICP/blood pressure (BP) ratio in dog models.
- Decreases the number of TL+-cells.
- Reduces the number of microglia/macrophages.
- Decreases flap necrosis by increasing the secretion of growth factors.
Medchemexpress LLC Sulfacetamide (standard) | 144-80-9 | 100 MG
Sulfacetamide (standard) | 144-80-9 | 100 MG
eMolecules 7411-23-6 | 3,5-DIBROMO-1H-1,2,4-TRIAZOLE | AstaTech | MFCD00487260 | 226.859 | C2HBr2N3 | 95.000 | Brc1n[nH]c(Br)n1 | 25g | 233626202
3,5-DIBROMO-1H-1,2,4-TRIAZOLE | AstaTech | 7411-23-6 | MFCD00487260 | 226.859 | C2HBr2N3 | 95.000 | Brc1n[nH]c(Br)n1 | 25g | 233626202
Apexbio Technology LLC Bosentan 147536-97-8 200mg
Bosentan (CAS 147536-97-8) is a small molecule that acts as a competitive antagonist at both endothelin-A (ET-A) and endothelin-B (ET-B) receptors By blocking the binding of endothelin-1 to these receptors bosentan modulates endothelin-mediated vasoconstriction and cellular proliferation pathways This compound is utilized in biomedical research to investigate the endothelin signaling axis and its role in cardiovascular physiology pulmonary hypertension and related pathologies Bosentan enables the study of receptor-specific effects of endothelin-1 inhibition and offers a tool for evaluating therapeutic strategies targeting the endothelin system
Selleck Chemical LLC MF-438
MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with IC50 of 2 3 nM for rSCD1
Matrix Scientific 3-METHOXYBENZENESULFONAMIDE-1G
3-Methoxybenzenesulfonamide, 97%; 1g,C7H9NO3S, MFCD08704579, mw 187.22, [58734-57-9]
Enzo Life Sciences Venetoclax (1g). CAS: 1257044-40-8
Venetoclax is a Bcl-2-selective inhibitor with Ki of <0.01 nM, >4800-fold more selective versus Bcl-xL and Bcl-w, and no activity to Mcl-1 Purity: ≥99% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -20°C.
Selleck Chemical LLC KN-92 phosphate
KN-92 is an inactive derivative of KN-93 the selective inhibitor of Ca2 /calmodulin-dependent kinase type II (CaMKII)
eMolecules 16548-07-5 | Ambeed | Ethylsulfamoyl chloride | 250mg | 572827644 | A215939 | MFCD12401754 | 143.59 | C2H6ClNO2S
Medchem Express | AGI-43192 | 5mg | 719836141 | HY-145777 | 2377491-54-6 | 484.870 | C23H16ClF3N6O
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eMolecules 139298-40-1 | Medchem Express | KN-93 | 1mg | 446265728 | HY-15465 | MFCD00236424 | 501.04 | C26H29ClN2O4S
ChemScene | 2-bromothiophen-3-amine hydrochloride | 100mg | 768992174 | CS-0021991 | 1803590-15-9 | MFCD27500915 | 214.510 | C4H5BrClNS
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Cayman Chemical Sildenafil Inhibitors
A PDE5 inhibitor (IC50s = 3.6 and 3 nM for PDE5 activity in isolated rabbit platelets and human corpus cavernosum, respectively); selective for PDE5 over PDE1 and PDE3 (IC50s = 0.26 and 65 μM, respectively); reverses glucose-induced decreases in ANG1 expression and reduction of capillary-like tube formation by mouse dermal endothelial cells in vitro; increases the number of functional blood vessels and regional blood flow in the sciatic nerve in a db/db mouse model of diabetic peripheral neuropathy; increases ICP/MAP ratio in castrated rats at 20 mg/kg per day; reduces cardiac arrest and resuscitation-induced increases in angiotensin II ACE, ACE2, and various angiotensin receptors and increases survival in a porcine model of ischemia/reperfusion injury
eMolecules 133745-75-2 | N-Fluorodibenzenesulfonimide | AA Blocks LLC | MFCD00144885 | 315.330 | C12H10FNO4S2 | 0.000 | FN(S(=O)(=O)c1ccccc1)S(=O)(=O)c1ccccc1 | 5g | 436000788
N-Fluorodibenzenesulfonimide | AA Blocks LLC | 133745-75-2 | MFCD00144885 | 315.330 | C12H10FNO4S2 | 0.000 | FN(S(=O)(=O)c1ccccc1)S(=O)(=O)c1ccccc1 | 5g | 436000788
Cayman Chemical Sildenafil Inhibitors
A PDE5 inhibitor (IC50s = 3.6 and 3 nM for PDE5 activity in isolated rabbit platelets and human corpus cavernosum, respectively); selective for PDE5 over PDE1 and PDE3 (IC50s = 0.26 and 65 μM, respectively); reverses glucose-induced decreases in ANG1 expression and reduction of capillary-like tube formation by mouse dermal endothelial cells in vitro; increases the number of functional blood vessels and regional blood flow in the sciatic nerve in a db/db mouse model of diabetic peripheral neuropathy; increases ICP/MAP ratio in castrated rats at 20 mg/kg per day; reduces cardiac arrest and resuscitation-induced increases in angiotensin II ACE, ACE2, and various angiotensin receptors and increases survival in a porcine model of ischemia/reperfusion injury