Biphenyls and derivatives

Medchemexpress LLC BIP-135 | 941575-71-9 | 99.9% | 421.24 | 100 MG

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Small and/or specialty supplier based on Federal laws and SBA requirements.
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BIP-135 | 941575-71-9 | 99.9% | 421.24 | 100 MG

Medchemexpress LLC BIP-135 | 941575-71-9 | 99.86% | 421.24 | 50 MG

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Small and/or specialty supplier based on Federal laws and SBA requirements.
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BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor, with IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. It exhibits a neuroprotective effect.

• Potent and selective ATP-competitive GSK-3 inhibitor
• IC50 for GSK-3α: 16 nM
• IC50 for GSK-3β: 21 nM
• Increases survival motor neuron (SMN) protein levels in human SMA fibroblasts
• Neuroprotective agent in models of oxidative stress
• Well-tolerated in animal studies; non-toxic
• Prolongs median survival time in SMA mouse models

Medchemexpress LLC BIP-135 | 941575-71-9 | 99.9% | 421.24 | 10 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor, with IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. It exhibits neuroprotective effects.

• Potent and selective ATP-competitive GSK-3 inhibitor.
• Exhibits neuroprotective effect.
• Increases survival motor neuron (SMN) protein levels in human SMA fibroblasts (at 25 μM).
• Superior neuroprotective agent in models of oxidative stress (at 20 μM).
• Prolongs median survival time in a Δ7 SMA KO mouse model of spinal muscular atrophy (at 75 mg/kg; i.p.; daily).

Medchemexpress LLC HY-111055 5mg Medchemexpress, BIP-135 CAS:941575-71-9 Purity:>98%

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Medchemexpress, HY-111055 5mg BIP-135 CAS:941575-71-9 BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor, with IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

eMolecules​ Medchem Express / BIP-135 / 5mg / 506403694 / HY-111055 / / 941575-71-9 / MFCD16495779 / 421.250 / C21H13BrN2O3

Medchem Express / BIP-135 / 5mg / 506403694 / HY-111055 / / 941575-71-9 / MFCD16495779 / 421.250 / C21H13BrN2O3