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(R)-eIF4A3-IN-2 is a less active enantiomer of eIF4A3-IN-2. It is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM. This compound targets eukaryotic initiation factor (eIF) and is involved in the cell cycle/DNA damage pathway.
Targets eukaryotic initiation factor (eIF)
Involved in cell cycle/DNA damage pathway
Powder storage: -20°C for 3 years, 4°C for 2 years
In solvent storage: -80°C for 2 years, -20°C for 1 year
Solubility in DMSO: 50 mg/mL (need ultrasonic)
In vivo solubility: ≥ 2.5 mg/mL in 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline
In vivo solubility: ≥ 2.5 mg/mL in 10% DMSO >> 90% corn oil
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(R)-eIF4A3-IN-2 is identified as a less active enantiomer of eIF4A3-IN-2. It functions as a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor, exhibiting an IC50 of 110 nM. Eukaryotic initiation factor 4A-3 (eIF4A3) is a DEAD (Asp-Glu-Ala-Asp) box-family adenosine triphosphate (ATP)-dependent RNA helicase.
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(R)-eIF4A3-IN-2 is the R-enantiomer of eIF4A3-IN-2 and a less-active stereoisomer of a selective, noncompetitive inhibitor of eukaryotic initiation factor 4A-3 (eIF4A3). The compound is supplied as a solid and is provided with recommended storage and solubility information for laboratory handling.
R enantiomer with reduced activity compared to the parent compound.
Selective, noncompetitive inhibitor of eIF4A3; parent IC50 = 110 nM.
CAS number 2095484-82-3.
Molecular formula C25H19Br2ClN4O2 and molecular weight 602.70.
Purity approximately 95.0% as supplied.
Physical form: solid, white to light yellow.
Storage: powder -20°C (3 years) or 4°C (2 years); in solution -80°C (2 years) or -20°C (1 year).
Solubility: soluble in DMSO (~50 mg/mL; ultrasonic assistance recommended).
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Medchemexpress, HY-21972 5mg BCI-121 CAS:432529-82-3 BCI-121 is a SMYD3 inhibitor that impairs the proliferation of cancer cell. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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