Cumenes
Medchemexpress LLC RO-3 | 1026582-88-6 | 97.3% | 302.37 | 5 MG
RO-3 is a potent, and orally active P2X3 and P2X2/3 antagonist with pIC50s of 5.9 and 7.0 for human homomultimeric P2X3 and heteromultimeric P2X2/3 receptors, respectively. It shows selectivity for P2X3 and P2X2/3 over all other functional homomultimeric P2X receptors (IC50 >10 μM at P2X1,2,4,5,7).
- Reduces afferent nerve activity induced by distension or α,β-meATP in guinea pig ureter-afferent nerve and mouse bladder-pelvic nerve preparations.
- Has activity in several rodent models of pain, as well as in cystometry models optimized to measure various parameters associated with sensory regulation of the micturition reflex.
- Exhibits moderate to high metabolic stability in rat and human hepatocytes and liver microsomes, is highly permeable, orally bioavailable (14%), and has a reasonable in vivo plasma half-life (t1/2=0.41 h) in rats.
- Appearance: Solid.
- Color: Yellow to orange.
Medchemexpress LLC Ro 5212773 (EPPTB) | 1110781-88-8 | 99.85% | 378.39 | 100 MG
Ro 5212773 (EPPTB) is a potent and selective trace amine-associated receptor 1 (TAAR1) antagonist (Ki=0.9 nM for mouse TAAR1), with no significant effects on other TAARs. TAAR1 is a G protein-coupled receptor (GPCR) that is nonselectively activated by endogenous metabolites of amino acids. This compound suppresses the excitability of hippocampal pyramidal neurons and reduces seizure-like events (SLEs) and seizure activity.
- Blocks TAAR1-mediated activation of an inwardly rectifying K+ current.
- Potently antagonizes cAMP production induced by activating mouse TAAR1 (IC50=27.5 nM).
- Dose-dependently reduces cAMP levels in HEK293 cells without TAAR1 agonist (IC50= 19 nM).
- More potent in antagonizing cAMP production by mouse TAAR1 compared to rat (IC50= 4539 nM) and human (IC50= 7487 nM) TAAR1.
Sigma Aldrich Fine Chemicals Biosciences HC-030031 >=98% (HPLC), powder | 349085-38-7 | MFCD02007349 | 10MG
HC-030031 >=98% (HPLC), powder | Purity: >=98% (HPLC) | Mol Wt: 355.39 | 349085-38-7 | MFCD02007349 | 10MG
Medchemexpress LLC HY-50713 10mg Medchemexpress, Calcium-Sensing Receptor Antagonists I CAS:478963-79-0 Purity:>98%
Medchemexpress, HY-50713 10mg Calcium-Sensing Receptor Antagonists I CAS:478963-79-0 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
eMolecules Medchem Express / CP-105696 / 5mg / 572596923 / HY-19193 / / 158081-99-3 / [null] / 428.528 / C28H28O4
Medchem Express / CP-105696 / 5mg / 572596923 / HY-19193 / / 158081-99-3 / [null] / 428.528 / C28H28O4
eMolecules Synthonix / 26-diiodo-4-methylphenol / 500mg / 794076147 / AC80888 / / 2432-18-0 / MFCD00088682 / 359.933 / C7H6I2O
Synthonix / 26-diiodo-4-methylphenol / 500mg / 794076147 / AC80888 / / 2432-18-0 / MFCD00088682 / 359.933 / C7H6I2O
Medchemexpress LLC HY-N5015 5mg Medchemexpress, Rosmanol CAS:80225-53-2 Purity:>98%
Medchemexpress, HY-N5015 5mg Rosmanol CAS:80225-53-2 Rosmanol could inhibit the oxidation of low density lipoprotein (LPL) and significantly inhibit lipopolysaccharide induced iNOS and COX-2 expression, with anti-inflammatory effect. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
eMolecules 2-(4-isopropylphenyl)pyridin-3-amine | 1308914-90-0 | MFCD21884503 | 1g
WuXi ChemSupply | 2-(4-isopropylphenyl)pyridin-3-amine | 1g | 599171171 | LN03295049 | 95.000 | 1308914-90-0 | MFCD21884503 | 212.296 | C14H16N2
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Medchemexpress LLC SU-4942 | 76086-99-2 | 99.6% | 300.15 | 50 MG
SU-4942 is a tyrosine kinase signal modulator that inhibits VEGF- and endothelial cell growth factor (ECGF)-induced mitogenesis in endothelial cells.
- Tyrosine kinase signal modulator
- Inhibits VEGF- and ECGF-induced mitogenesis in endothelial cells
- Solid appearance
- Light yellow to yellow color
- Molecular weight: 300.15
- Purity: 99.6%
eMolecules Medchem Express / Rosmanol / 5mg / 434310730 / HY-N5015 / / 80225-53-2 / MFCD12031636 / 346.423 / C20H26O5
Medchem Express / Rosmanol / 5mg / 434310730 / HY-N5015 / / 80225-53-2 / MFCD12031636 / 346.423 / C20H26O5
Medchemexpress LLC HY-101441A 5mg Medchemexpress, ST-193 (hydrochloride) CAS: Purity:>98%
Medchemexpress, HY-101441A 5mg ST-193 (hydrochloride) CAS: ST-193 hydrochloride is a potent broad-spectrum arenavirus inhibitor; inhibits Guanarito, Junin, Lassa and Machupo virus with IC 50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
eMolecules 2-Amino-4-isopropylphenol | 3280-68-0 | MFCD00092806 | 1g
Combi-Blocks | 2-Amino-4-isopropylphenol | 1g | 528671018 | JL-6195 | 95.000 | 3280-68-0 | MFCD00092806 | 151.209 | C9H13NO
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Sigma Aldrich Fine Chemicals Biosciences Amlexanox >=98% (HPLC) | 68302-57-8 | MFCD00864790 | 50MG
Amlexanox >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 298.29 | 68302-57-8 | MFCD00864790 | 50MG
Medchemexpress LLC Tetrahydropiperine | 23434-88-0 | MFCD17167032 | 99.4% | 289.37 g·mol-1 | C17H23NO3 | 10 MG
Tetrahydropiperine is a research-grade small molecule used to probe inflammatory and survival signaling pathways in cellular and biochemical studies. It acts on NF-κB and MAPK signaling and modulates the PI3K/Akt/mTOR pathway.
- Selective inhibitor of NF-κB and MAPKs, useful for pathway studies.
- Modulates PI3K/Akt/mTOR signaling for research on cell survival.
- High purity solid, suitable for analytical and cellular assays.
- Available in small research pack sizes for screening and mechanism-of-action work.
- Molecular weight approximately 289.37 g·mol-1 and formula C17H23NO3.
eMolecules 1-(4-Isopropylphenyl)propan-1-one | 27465-52-7 | MFCD01095865 | 25g
Combi-Blocks | 1-(4-Isopropylphenyl)propan-1-one | 25g | 439371923 | QY-8650 | 97.000 | 27465-52-7 | MFCD01095865 | 176.259 | C12H16O
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