Cyclohexylphenols

Medchemexpress LLC Fraxinol | 486-28-2 | MFCD08693526 | 98.8% | 222.19 g·mol⁻¹ | C11H10O5 | 10 MG

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Fraxinol is a naturally derived coumarin isolated from Lobelia chinensis and used as a cytochrome P450 inhibitor for research applications. It is supplied as a light yellow solid with high reported purity, documented solubility in DMSO, and recommended storage conditions for both solid and solution forms.

• Purity: 98.82%.
• CAS number: 486-28-2.
• Molecular formula: C11H10O5; molecular weight: 222.19 g·mol⁻¹.
• Biological target: cytochrome P450 enzymes.
• Solubility: DMSO 25 mg/mL (in vitro); in vivo formulations yield ≥2.5 mg/mL.
• Storage: sealed at 4°C; in solvent store at -80°C (6 months) or -20°C (1 month).
• Typical applications: in vitro and in vivo metabolic enzyme studies.
• Physical form: light yellow to yellow solid.

Medchemexpress LLC 2-methyl-1,3-cyclohexanedione | 1193-55-1 | MFCD00001587 | 99.9% | 126.15 g/mol | C7H10O2 | 10 G

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2-Methyl-1,3-cyclohexanedione is a small-molecule reagent used primarily as a drug-synthetic intermediate and laboratory research chemical. It is offered in multiple pack sizes and reported at high purity for use in organic synthesis and related applications. Listed uses include research-only applications and potential cosmetic ingredient uses where applicable.

• High reported purity (listed as 99.86% on supplier documentation).
• Molecular formula C7H10O2 and molecular weight 126.15 g/mol.
• Intended for research and synthesis applications as a building block.
• Available in a range of pack sizes suitable for laboratory use.
• Supplied with safety and datasheet documentation for laboratory handling.

Medchemexpress LLC Trispiro[3H-indole-3,2'-dioxane-5',5''-dioxane-2'',3'''-[3H]indole]-2,2'''-dione | 442644-28-2 | MFCD03036757 | 98.15% | 394.38 | 10 MG

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JW67 inhibits canonical Wnt signaling with an IC50 of 1.17 μM. It affects the multiprotein complex of β-catenin/GSK-3β/AXIN/APC/CK1, leading to a rapid reduction in active β-catenin and downregulation of Wnt target genes. This compound also inhibits colorectal cancer cell growth and reduces cell viability in SW480 cells.

• Inhibits canonical Wnt signaling with an IC50 of 1.17 μM
• Reduces active β-catenin and downregulates Wnt target genes
• Inhibits colorectal cancer cell growth
• Increases AXIN2 concentration and decreases active β-catenin in vitro
• Reduces colon cancer cell growth in vitro
• Shows concentration-dependent reduction in proliferation with a GI50 value of 7.8 μM

Medchemexpress LLC 3-[[[5-(6-Methyl-2-pyridinyl)-4-triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]methyl]amino]benzonitrile | 1352609-28-9 | 98.8% | 406.44 | C23H18N8 | 10 MG

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EW-7195 is a potent, selective ALK5 (TGFβR1) inhibitor for research use that blocks TGF-β1-induced Smad signaling, epithelial-to-mesenchymal transition, and metastatic progression in preclinical studies. It provides low-nanomolar potency and is supplied with high purity for laboratory assays.

• Potent ALK5 inhibition with low-nanomolar IC50.
• High selectivity over related kinases, >300-fold versus p38α.
• Blocks TGF-β1-induced Smad signaling and epithelial-to-mesenchymal transition.
• Demonstrated anti-metastasis activity in preclinical models.
• High purity suitable for research applications.
• Soluble in DMSO for assay preparation.

Medchemexpress LLC Trispiro[3H-indole-3,2'-dioxane-2",3'''-[3H]indole]-2,2'''(1H,1'''H)-dione | 442644-28-2 | MFCD03036757 | 98.2% | 394.38 g·mol⁻¹ | C21H18N2O6 | 5 MG

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JW67 (CAS 442644-28-2) is a small-molecule research inhibitor of canonical Wnt signaling that reduces active β-catenin by modulating the β-catenin/GSK-3β/AXIN/APC/CK1 multiprotein complex. It shows reported activity against colorectal cancer cell growth and is supplied for laboratory use as a light-yellow solid or as a 10 mM solution in DMSO.

• Inhibits canonical Wnt signaling (IC50 1.17 μM).
• Reduces active β-catenin via multiprotein complex modulation.
• Reported activity against colorectal cancer cell growth.
• Supplied in solid and solution formats for research use.
• High purity (≈98.2%).
• Molecular weight 394.38 g·mol⁻¹; formula C21H18N2O6.
• Stable under recommended storage conditions for powder and solvent preparations.