Styrenes
![eMolecules 253199-08-5 | trans,trans-4-(4-Ethoxy-2,3-difluorophenyl)-4'-ethyl-1,1'-bi(cyclohexane) | Ambeed350.494 | C22H32F2O | 95.000 | CCOc1ccc([C@H]2CC[C@@H](CC2)[C@H]2CC[C@H](CC)CC2)c(F)c1F | 5g | 666598308](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502424818.PNG-250.jpg)
eMolecules 253199-08-5 | trans,trans-4-(4-Ethoxy-2,3-difluorophenyl)-4'-ethyl-1,1'-bi(cyclohexane) | Ambeed350.494 | C22H32F2O | 95.000 | CCOc1ccc([C@H]2CC[C@@H](CC2)[C@H]2CC[C@H](CC)CC2)c(F)c1F | 5g | 666598308
trans,trans-4-(4-Ethoxy-2,3-difluorophenyl)-4'-ethyl-1,1'-bi(cyclohexane) | Ambeed | 253199-08-5350.494 | C22H32F2O | 95.000 | CCOc1ccc([C@H]2CC[C@@H](CC2)[C@H]2CC[C@H](CC)CC2)c(F)c1F | 5g | 666598308
TARGETMOL CHEMICALS INC SACLOFEN 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Saclofen is a sulfonic analog of the inhibitory neurotransmitter (gamma)-aminobutyric acid (GABA) that acts as a competitive antagonist of the GABAB receptor (IC50 7.8 uM).1 This compound can be used to determine the functional roles for the GABAB receptor as a mediator of slow inhibitory postsynaptic potentials in the brain. purity: 99%
Selleck Chemical LLC NMS-873
NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases Hsp90 and 53 additional analyzed kinases (IC50s 10 M)
Matrix Scientific TRIS(DIBENZYLIDENEACETONE)DI-1
Tris(dibenzylideneacetone)dipalladium-chloroform Adduct Mf C52h43cl3o3pd2 Mw 1035.08 Cas 52522-40-4 Mdl MFCD00075479
Medchemexpress LLC N-(4-benzyl-3-methyl-1,2,4-thiadiazol-5-ylidene)-N'-phenylbenzenecarboximidamide | 324579-65-9 | 99.9% | 384.50 g/mol | C23H20N4S | 10MM 1ML
RNF5 inhibitor inh-02 is a small-molecule inhibitor of the E3 ubiquitin ligase RNF5 used in research to rescue F508del-CFTR function and to study autophagy and ubiquitin-mediated proteostasis. The compound has molecular formula C23H20N4S, exact mass 384.50 g/mol, and is typically provided as a 10 mM solution in DMSO or as solid quantities for assay and synthesis work.
- Potent inhibitor of E3 ubiquitin ligase RNF5 with cell-based activity (EC50 ≈ 2.2-2.6 μM).
- Available as 10 mM solution in DMSO and as multiple solid pack sizes.
- High purity (99.9%).
- Recommended solvent for solution preparation: DMSO.
- Storage: powder -20°C (up to 3 years); in solvent -80°C (6 months) or -20°C (1 month).
- Suitable for cystic fibrosis research and studies of protein quality control and autophagy.
Medchemexpress LLC K858 (Racemic) | 72926-24-0 | 99.83% | 277.35 | 10 MM * 1 ML
K858 (Racemic) is an ATP-uncompetitive inhibitor of kinesin Eg5 with an IC50 of 1.3 μM. It is intended for research use only and is not sold to patients.
- Acts as an ATP-uncompetitive inhibitor of kinesin Eg5 (IC50 of 1.3 μM).
- Induces mitotic arrest and growth inhibition by activating the Mad2-mediated spindle checkpoint.
- Induces mitotic cell death in cancer cells but not in normal cells at 5 μM.
- Inhibits MCF7, BT474, and SKBR3 cell lines at 10 and 100 μM, and MDA-MB231 cell line at 10 and 100 μM after 24 hours.
- Increases Bax/Bcl2 RNA ratio and survivin in four cell lines.
- Upregulation of survivin is reversed by wortmannin (phosphoinositide 3-kinase AKT) in MCF7 cells.
- Shows antitumor activity in A2780 ovarian cancer xenograft and HCT116 colon cancer xenograft models.
- No neurotoxic side effects observed in mice at 100 mg/kg.
Apexbio Technology LLC Protease Inhibitor Cocktail for bacterial cell extracts (100 X in DMSO) 1ml A 1ml B
Under stable environmental conditions endogenous protein synthesis and degradation are balanced thus maintaining stable cellular protein levels Cell crude extracts contain numerous endogenous enzymes such as phosphatases and proteases that can degrade proteins in the extracts During in vitro protein extraction from cells and tissues protein synthesis practically ceases while protein degradation increases The optimal way to enhance yields of intact proteins is to add inhibitors for these known enzymes The Protease Inhibitor Cocktail for bacterial cell extracts (100X in DMSO) is designed for bacterial extracts to enhance the stability of proteins This cocktail inhibits proteases responsible for degrading non-phosphorylated or phosphorylated protein substrates This Protease Inhibitor Cocktail is provided as a ready-to-use solution and it is formulated in DMSO
eMolecules 28447-20-3 | 3-Vinylbenzoic acid | Combi-Blocks | MFCD00157038 | 148.161 | C9H8O2 | 96.000 | OC(=O)c1cccc(C=C)c1 | 5g | 537624544
3-Vinylbenzoic acid | Combi-Blocks | 28447-20-3 | MFCD00157038 | 148.161 | C9H8O2 | 96.000 | OC(=O)c1cccc(C=C)c1 | 5g | 537624544
![Medchemexpress LLC 1,3,4,5-tetrahydro-4-methyl-6-[1-methyl-3-(1-methyl-pyrazol-4-yl)-indazol-5-yl]-benzodiazepin-2-one | 1884712-47-3 | 100.0% | 386.45 g/mol | C22H22N6O | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000215451.png-250.jpg)
Medchemexpress LLC 1,3,4,5-tetrahydro-4-methyl-6-[1-methyl-3-(1-methyl-pyrazol-4-yl)-indazol-5-yl]-benzodiazepin-2-one | 1884712-47-3 | 100.0% | 386.45 g/mol | C22H22N6O | 1 ML
CPI-637 is a selective, cell-active benzodiazepinone inhibitor of CBP and EP300 bromodomains with potent biochemical activity and demonstrated cellular effects. It inhibits CBP and EP300 with low-nanomolar IC50 values, shows reduced activity against BRD4 BD-1, and is supplied as a concentrated solution for research use.
- Selective CBP and EP300 bromodomain inhibition.
- Potent biochemical activity (low-nanomolar IC50 values).
- Cell-active with measurable EC50 in cellular assays.
- Supplied as a concentrated solution for convenient dosing in assays.
- Suitable for epigenetics and cancer biology research applications.
- Reported high chemical purity for reproducible results.
Strem, An Ascensus Company CAS# 52522-40-4. Tris(dibenzylideneacetone)dipalladium(0) chloroform adduct. MFCD00075479. 500MG
CAS# 52522-40-4. 500MG. Tris(dibenzylideneacetone)dipalladium(0) chloroform adduct. MFCD00075479. Molecular Formula: C52H43Cl3O3Pd2. Molecular Weight: 1035.08. Color/Form: red to brown solid. Stability: air sensitive, moisture sensitive. Strem#: 46-3010 www.strem.com/catalog/v3/46-3010/
Apexbio Technology LLC NMS-873 1418013-75-8 50mg
NMS-873 (CAS 1418013-75-8) is a selective inhibitor of the ATPase VCP/p97 demonstrating inhibitory activity with an IC50 value of 30 nM It targets wild-type VCP as well as VCPC522T mutants without disrupting VCP oligomerization NMS-873 exhibits selectivity against other AAA ATPases HSP90 and various kinases In tumor cell lines including HCT-116 treatment with NMS-873 induces accumulation of polyubiquitinated proteins and stabilization of cyclin E and Mcl-1 leading to altered cell-cycle distribution and reduced cell proliferation NMS-873 shows cytotoxicity across blood cancer and solid tumor cell models (IC50 values 0 08 2 M) supporting its utility in oncology research