Styrenes
Chemscene ChemScene | 4-Bromostilbene | 10G | CS-0121764 | 0.98 | 4714-24-3| MFCD00155020 | 259.15
ChemScene | 4-Bromostilbene | 10G | CS-0121764 | 0.98 | 4714-24-3| MFCD00155020 | 259.15
Medchemexpress LLC 2-((5-bromo-2-((1-(methylsulfonyl)piperidin-4-yl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide | 2488892-01-7 | 99.4% | 487.35 g/mol | C17H20BrFN6O3S | 10 MG
TMX-2039 is a research-grade pan-cyclin-dependent kinase (pan-CDK) inhibitor intended for biochemical and cellular studies of cell cycle and transcriptional CDKs. Supplied as an off-white to light yellow solid with high reported purity, it is suitable for assay development, mechanism-of-action experiments, and probe validation in research settings.
- Pan-CDK activity covering cell cycle and transcriptional CDKs.
- High purity (≈99.4%) suitable for research applications.
- Supplied as a solid powder for flexible formulation and dosing.
- Available in small research-friendly pack sizes, e.g. 10 mg.
- Stable under recommended storage: 4°C under nitrogen; in solvent, -80°C for 6 months or -20°C for 1 month.
- Provides consistent material for biochemical and cellular assays.
Medchemexpress LLC Gt-653 | 3057627-63-8 | 99.8% | 653.60 | C32H27N7O9 | 10 MG
GT-653 is a PROTAC degrader that targets lysine-specific demethylase 5B (KDM5B), promoting ubiquitin-proteasome-dependent degradation and modulating H3K4 methylation in cellular models. It is supplied as a white to off-white solid for research use in biochemical and cellular studies of epigenetic regulation.
- PROTAC mechanism targeting KDM5B, a histone demethylase.
- Demonstrated 68.35% degradation of KDM5B at 10 μM in cell assays.
- Upregulates H3K4me3 levels and activates type-I interferon signaling in prostate cancer cells.
- Available as a white to off-white powder suitable for in vitro studies.
- Molecular formula C32H27N7O9; molecular weight 653.60.
eMolecules trans-4-Phenyl-cyclohexylamine hydrochloride | 5769-08-4 | | 1g
J & W PharmLab LLC | trans-4-Phenyl-cyclohexylamine hydrochloride | 1g | 491379591 | 20R1690S | 96.000 | 5769-08-4 | | 211.730 | C12H18ClN
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TARGETMOL CHEMICALS INC 653-47 hydrochloride 5MG
Also available in 1 mL, 1 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. 653-47 hydrochloride is a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. It is also a very weak CREB inhibitor with IC50 of 26.3 uM. Purity 99.65%
eMolecules trans-1-Decalone | 21370-71-8 | MFCD00064175 | 100mg
Oakwood Chemical | trans-1-Decalone | 100mg | 537719759 | 245835 | | 21370-71-8 | MFCD00064175 | 152.237 | C10H16O
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Medchemexpress LLC K858 (Racemic) | 72926-24-0 | 99.8% | 277.34 | 25 MG
K858 Racemic is an ATP-uncompetitive inhibitor of kinesin Eg5 with an IC50 of 1.3 μM.
- Does not inhibit the ATPase activity of the mitotic kinesins CENP-E and MKLP1, or the conventional kinesin heavy chain even at 200 μM.
- Induces mitotic arrest and growth inhibition via the activation of the Mad2-mediated spindle checkpoint.
- Induces mitotic cell death in cancer cells but not in normal cells (at 5 μM).
- Shows antitumor activity in an A2780 ovarian cancer xenograft model, and also inhibits tumor growth in a HCT116 colon cancer xenograft model.
- Displays no neurotoxic side effects in mice (at 100 mg/kg, p.o., qd x5).
Selleck Chemical LLC CPI-637
CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor with IC50 values of 0 03 M and 0 051 M for CBP and EP300 respectively in TR-FRET assay It is highly selective against other bromodomains displaying substantial biochemical activity only against BRD9
Selleck Chemical LLC NMS-873
NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases Hsp90 and 53 additional analyzed kinases (IC50s 10 M)
Medchemexpress LLC Nms-873 | 1418013-75-8 | MFCD28009371 | >98% | 520.67 | C27H28N4O3S2 | 10 MG
NMS-873 is a potent, selective allosteric inhibitor of the VCP/p97 ATPase used in research to study protein homeostasis, ubiquitin-proteasome system dysfunction, and cell-cycle/DNA damage pathways. It exhibits strong biochemical inhibition (IC50 30 nM) and antiproliferative activity in cell lines at sub-micromolar concentrations.
- Potent allosteric inhibition of VCP/p97 (IC50 30 nM).
- Demonstrates antiproliferative activity in tumor cell lines (cellular IC50 ~0.08-2 μM).
- Suitable for cell-based assays and biochemical studies of protein degradation and autophagy.
- Provided as a solid with recommended storage conditions for powder and solutions.
- Available in small-scale quantities (for example, 1 mg, 5 mg, 10 mg) for laboratory experiments.
eMolecules Medchem Express / Avoralstat / 5mg / 446267786 / HY-16735 / / 918407-35-9 / MFCD28502152 / 513.554 / C28H27N5O5
Medchem Express / Avoralstat / 5mg / 446267786 / HY-16735 / / 918407-35-9 / MFCD28502152 / 513.554 / C28H27N5O5