Styrenes
Medchemexpress LLC K858 (Racemic) | 72926-24-0 | 99.8% | 277.35 | 5 MG
K858 (Racemic) is an ATP-uncompetitive inhibitor of kinesin Eg5, with an IC50 of 1.3 μM. It specifically induces mitotic arrest and growth inhibition by activating the Mad2-mediated spindle checkpoint, leading to mitotic cell death in cancer cells without affecting normal cells. It also shows antitumor activity in ovarian and colon cancer xenograft models in vivo.
- ATP-uncompetitive inhibitor of kinesin Eg5
- Induces mitotic arrest and growth inhibition
- Activates the Mad2-mediated spindle checkpoint
- Induces mitotic cell death in cancer cells at 5 μM
- Shows antitumor activity in A2780 ovarian and HCT116 colon cancer xenograft models
- Displays no neurotoxic side effects in mice
eMolecules 132465-11-3 | Medchem Express | Cinnamyl-34-dihydroxy--cyanocinnamate | 5mg | 596608155 | HY-138688 | MFCD00210839 | 321.332 | C19H15NO4
Ambeed | 26-Difluoro-3-methylphenylboronic acid | 100mg | 717401674 | A665657 | 1586045-40-0 | MFCD09265479 | 171.940 | C7H7BF2O2
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Pfaltz & Bauer 1 6-Diphenylhexatriene 98%| 1G | 1720-32-7
1 6-Diphenylhexatriene 98%| 1G | 1720-32-7
Medchemexpress LLC K858 (Racemic) | 72926-24-0 | 99.83% | 277.35 | 50 MG
K858 (Racemic) | 72926-24-0 | 99.83% | 277.35 | 50 MG
TARGETMOL CHEMICALS INC BETA-ACETOXYISOVALERYLSH 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Beta-Acetoxyisovalerylshikonin is a natural product for research related to life sciences. The catalog number is T5S2350 and the CAS number is 69091-17-4. purity: 99%
Medchemexpress LLC Microtubule stabilizer-1 | 2699937-76-1 | 99.5% | 390.82 | 50 MG
Microtubule stabilizer-1, also known as compound 69, is a potent brain-penetrant microtubule (MT) stabilizer. It works by increasing acetylated α-tubulin (AcTub) levels and preventing the loss of neuronal MTs observed after exposure to Okadaic acid. This makes it a valuable tool for research into Alzheimer's disease (AD) and other neurodegenerative tauopathies.
- Increases acetylated α-tubulin levels
- Prevents neuronal microtubule loss
- Useful for Alzheimer's disease and tauopathies research
- Off-white solid appearance
- High purity for reliable research applications
Medchemexpress LLC PFI-653 (Vanin-1-IN-1) | 2173134-00-2 | 99.9% | 25 MG
PFI-653 is a chemical probe and a vanin-1 inhibitor. It binds to plasma vanin-1 from mouse, rat, dog, and human. Vanin-1 is a cell surface-associated inositol (GPi)-anchored protein crucial in metabolism and inflammation.
- Binds to plasma vanin-1 from multiple species
- Inhibits vanin-1, a GPi-anchored protein important in metabolism and inflammation
- Exhibits nanomolar IC50 values for vanin-1 inhibition across species
Medchemexpress LLC K858 (Racemic) | 72926-24-0 | 99.83% | 277.35 | 10 MM * 1 ML
K858 (Racemic) is an ATP-uncompetitive inhibitor of kinesin Eg5 with an IC50 of 1.3 μM. It is intended for research use only and is not sold to patients.
- Acts as an ATP-uncompetitive inhibitor of kinesin Eg5 (IC50 of 1.3 μM).
- Induces mitotic arrest and growth inhibition by activating the Mad2-mediated spindle checkpoint.
- Induces mitotic cell death in cancer cells but not in normal cells at 5 μM.
- Inhibits MCF7, BT474, and SKBR3 cell lines at 10 and 100 μM, and MDA-MB231 cell line at 10 and 100 μM after 24 hours.
- Increases Bax/Bcl2 RNA ratio and survivin in four cell lines.
- Upregulation of survivin is reversed by wortmannin (phosphoinositide 3-kinase AKT) in MCF7 cells.
- Shows antitumor activity in A2780 ovarian cancer xenograft and HCT116 colon cancer xenograft models.
- No neurotoxic side effects observed in mice at 100 mg/kg.
![Medchemexpress LLC 1,3,4,5-tetrahydro-4-methyl-6-[1-methyl-3-(1-methyl-pyrazol-4-yl)-indazol-5-yl]-benzodiazepin-2-one | 1884712-47-3 | 100.0% | 386.45 g/mol | C22H22N6O | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000215451.png-250.jpg)
Medchemexpress LLC 1,3,4,5-tetrahydro-4-methyl-6-[1-methyl-3-(1-methyl-pyrazol-4-yl)-indazol-5-yl]-benzodiazepin-2-one | 1884712-47-3 | 100.0% | 386.45 g/mol | C22H22N6O | 1 ML
CPI-637 is a selective, cell-active benzodiazepinone inhibitor of CBP and EP300 bromodomains with potent biochemical activity and demonstrated cellular effects. It inhibits CBP and EP300 with low-nanomolar IC50 values, shows reduced activity against BRD4 BD-1, and is supplied as a concentrated solution for research use.
- Selective CBP and EP300 bromodomain inhibition.
- Potent biochemical activity (low-nanomolar IC50 values).
- Cell-active with measurable EC50 in cellular assays.
- Supplied as a concentrated solution for convenient dosing in assays.
- Suitable for epigenetics and cancer biology research applications.
- Reported high chemical purity for reproducible results.
Apexbio Technology LLC NMS-873 1418013-75-8 50mg
NMS-873 (CAS 1418013-75-8) is a selective inhibitor of the ATPase VCP/p97 demonstrating inhibitory activity with an IC50 value of 30 nM It targets wild-type VCP as well as VCPC522T mutants without disrupting VCP oligomerization NMS-873 exhibits selectivity against other AAA ATPases HSP90 and various kinases In tumor cell lines including HCT-116 treatment with NMS-873 induces accumulation of polyubiquitinated proteins and stabilization of cyclin E and Mcl-1 leading to altered cell-cycle distribution and reduced cell proliferation NMS-873 shows cytotoxicity across blood cancer and solid tumor cell models (IC50 values 0 08 2 M) supporting its utility in oncology research
eMolecules 4282-42-2 | 1-Iodononane (stabilized over Cu) | Oakwood Chemical | MFCD00001107 | 254.155 | C9H19I | 0.000 | CCCCCCCCCI | 25g | 537711944
1-Iodononane (stabilized over Cu) | Oakwood Chemical | 4282-42-2 | MFCD00001107 | 254.155 | C9H19I | 0.000 | CCCCCCCCCI | 25g | 537711944
Sigma Aldrich Fine Chemicals Biosciences beta Galactosidase from Es
-Galactosidase is a tetramer consisting of four equal subunits of 135 000 each. It is a sulfhydryl containing enzyme with 19 cysteine residues per subunit.