4-alkoxyphenols
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Medchemexpress LLC 20-(tert-butoxy)-20-oxoicosanoic acid | 683239-16-9 | MFCD23136041 | 99.9% | 398.62 g/mol | C24H46O4 | 25 G
20-(tert-butoxy)-20-oxoicosanoic acid is an alkyl chain linker used as a non-cleavable linker for antibody-drug conjugates (ADCs) and as an alkyl chain-based linker in PROTAC synthesis. Supplied as a high-purity research-grade compound, it is intended for use in medicinal chemistry and synthetic linker construction.
- High purity (99.9%).
- Molecular weight 398.62 g/mol.
- Chemical formula C24H46O4.
- Available in 25 g packaging.
- Powder storage: -20°C for long-term stability.
- Intended application: ADC and PROTAC linker synthesis.
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Medchemexpress LLC 1,1,1,3,3,3-hexafluoropropan-2-yl 4-(3-phenoxybenzyl)piperazine-1-carboxylate | 1416133-89-5 | MFCD22987956 | 99.9% | 462.39 | C21H20F6N2O3 | 50MG
JW-642 is a research-grade, selective inhibitor of monoacylglycerol lipase (MAGL) used to probe endocannabinoid signaling and lipid metabolism. It provides low-nanomolar potency against MAGL across species while showing much weaker activity against fatty acid amide hydrolase, supporting its use as a selective pharmacological tool.
- Potent MAGL inhibition in human, mouse, and rat (IC50: 3.7 nM human; 7.6 nM mouse; 14 nM rat).
- Reduced activity versus FAAH (micromolar IC50s), indicating selectivity.
- High purity (99.9% by HPLC) for consistent experimental performance.
- Solid, stable material suitable for analytical and preparative applications.
- Recommended storage under nitrogen at 4°C; in solution store at -80°C for long-term stability.
- Suitable for biochemical, enzymatic, and cell-based assays.