Aminophenols
Medchemexpress LLC Zzw-115 hydrochloride | 10122-45-9 | 98.1 % | 573.97 | 5 MG
ZZW-115 hydrochloride is a potent NUPR1 inhibitor with a Kd of 2.1 μM. It induces tumor cell death through necroptosis and apoptosis, demonstrating anticancer activity. It is efficient in killing various cancer cells with IC50 values ranging from 0.42 μM to 4.93 μM. This compound also induces a decrease in ATP production and a ROS overproduction.
- Efficient in killing cancer cells with IC50 values ranging from 0.42 μM to 7.75 μM
- Induces tumor cell death via necroptosis and apoptosis
- Decreases ATP production and induces ROS overproduction
- Inhibits the growth of pancreatic xenografted tumors in vivo
- Demonstrates potent anticancer activity
Medchemexpress LLC Guvacine hydrochloride | 6027-91-4 | MFCD00055191 | 99.9% | 163.60 g/mol | C6H10ClNO2 | 1 ML
Guvacine hydrochloride is a GABA transporter inhibitor used in neuroscience research to investigate GABAergic signaling and transporter pharmacology. It is supplied with documented purity, molecular data, and recommended storage conditions to support reliable in vitro experiments.
- Inhibits GABA transporter activity with reported IC50 values for multiple transporter subtypes.
- Supplied as a ready-to-use 10 mM solution in DMSO (1 ML) for immediate use in assays.
- Also available as a solid for custom preparation and long-term storage.
- High reported purity supports reproducible experimental results.
- Storage guidance provided to maintain stability of solid and solution forms.
Medchemexpress LLC Melk-8a (hydrochloride) | 2096992-20-8 | 99.3% | 469.02 | C25H33ClN6O | 500 MG
MELK-8a hydrochloride is a potent, selective inhibitor of maternal embryonic leucine zipper kinase (MELK) with an enzymatic IC50 of 2 nM. Supplied as the hydrochloride salt, the compound shows cellular activity in cancer cell lines, with reported good solubility and permeability, and is intended for research use only.
- Potent MELK inhibition (IC50 2 nM).
- High purity (>99%).
- Good solubility and permeability in cellular assays.
- Demonstrated activity in cancer cell lines (MDA-MB-468, MCF-7).
- Documentation available: product data sheet and safety data sheet.
Selleck Chemical LLC OTS514 hydrochloride-2mg
OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis.
eMolecules Pharmablock / ethyl (3S)-3-(4-hydroxyphenyl)hex-4-ynoate / 25mg / 551208238 / PB05708 / 0.000 / 1292290-97-1 / MFCD27956896 / 232.279 / C14H16O3
Pharmablock / ethyl (3S)-3-(4-hydroxyphenyl)hex-4-ynoate / 25mg / 551208238 / PB05708 / 0.000 / 1292290-97-1 / MFCD27956896 / 232.279 / C14H16O3
Medchemexpress LLC Imiloxan hydrochloride | 81167-22-8 | MFCD01074788 | >98.0% | 280.75 | C14H17ClN2O2 | 25 MG
Imiloxan hydrochloride is the hydrochloride salt of imiloxan, a potent and selective α2B-adrenoceptor antagonist used in pharmacology research. Supplied as a solid reagent, it is intended for distinguishing α2 receptor subtypes and for probing adrenergic signaling in both in vitro and in vivo studies.
- Potent, selective α2B-adrenoceptor antagonist for receptor pharmacology.
- Suitable for both in vitro and in vivo pharmacodynamic studies.
- High purity (≥98% HPLC) supporting reproducible results.
- Hydrochloride salt form improves aqueous solubility for dosing.
- Available in small research pack sizes appropriate for screening and dosing.
- Molecular formula C14H17ClN2O2; molecular weight 280.75 g/mol.
Medchemexpress LLC di-Pal-MTO | 1349197-90-5 | 98.4% | 917.27 | 5 MG
di-Pal-MTO is a palm oil-based lipid created by combining the anticancer agent mitoxantrone (MTO) with palmitoleic acid. When formulated into nanoparticles with mono-Pal-MTO in a 1:1 molar ratio, it demonstrates effective siRNA cell delivery and enhanced anticancer activity. This combination has been shown to significantly reduce tumor cell viability by 81% and tumor size by 83% in vitro, outperforming Lipofectamine 2000-mediated transfection.
- Palm oil-based lipid, combining mitoxantrone (MTO) and palmitoleic acid.
- Effective siRNA cell delivery, enhanced anticancer activity.
- Forms nanoparticles (1:1 molar ratio with mono-Pal-MTO) for effective siRNA delivery.
- Enhances in vitro antitumor activity, reducing tumor cell viability by 81% and tumor size by 83%.
Medchemexpress LLC Afm32a hydrochloride | 2988594-85-8 | 99.7% | 517.00 g/mol | C25H30ClFN6O3 | 5 MG
AFM32a hydrochloride is a benzimidazole-derived small-molecule inhibitor selective for protein arginine deiminase 2 (PAD2). Supplied as the hydrochloride salt for research use, it is suitable for biochemical assays and target validation, demonstrating approximately 95-fold selectivity for PAD2 versus PAD4 and 79-fold versus PAD3.
- Potent PAD2 inhibition with high selectivity over PAD3 and PAD4.
- Hydrochloride salt form for improved solubility and handling.
- High purity (≈99.7%) appropriate for biochemical assays.
- Available in small-mass and DMSO solution formats for screening.
- Characterized with molecular formula and molecular weight for analytical use.
Medchemexpress LLC O-(6-Chlorobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate | 330645-87-9 | 99.4% | 413.69 | 1000 G
HCTU is a biochemical reagent that can be used as a biological material or organic compound for life science related research. It is for research use only and not sold to patients.
Medchemexpress LLC NPS-2143 hydrochloride | 324523-20-8 | MFCD16038896 | 100.0% | 445.4 g/mol | C24H26Cl2N2O2 | 1 MG
NPS-2143 hydrochloride is an orally active calcilytic agent that acts as a selective and potent antagonist of the calcium-sensing receptor (CaSR). Supplied as a high-purity solid for research use, it is used in biochemical and cellular studies to probe CaSR-mediated signaling and parathyroid hormone regulation.
- Selective calcium-sensing receptor antagonist for targeted research applications.
- High purity suitable for biochemical and cellular assays.
- Solid form for convenient storage and handling.
- Small research-scale quantity for assay development and proof-of-concept studies.
Medchemexpress LLC Ly266097 hydrochloride | 172895-39-5 | MFCD00949080 | >98.0% | 407.33 g·mol⁻¹ | C21H23ClN2O2 · HCl | 25 MG
LY266097 hydrochloride is the hydrochloride salt of LY-266,097, a potent and selective 5-HT2B receptor antagonist used as a research reagent in neuroscience and pharmacology. It is supplied as a crystalline solid, typically at high purity, and is used for receptor binding and functional studies in vitro and in vivo.
- Selective 5-HT2B receptor antagonist for neuroscience research.
- High purity (typically ≥98%) for analytical and biological assays.
- Available as powder or as a 10 mM solution in DMSO, in milligram-scale packs.
- Molecular weight ~407.33 g·mol⁻¹; empirical formula C21H23ClN2O2 · HCl.
- Suited for receptor binding, functional assays, and pharmacology studies.
Medchemexpress LLC Fasudil hydrochloride | 105628-07-7 | MFCD00943198 | 100.0% | 327.83 g/mol | C14H18ClN3O2S | 1 G
Fasudil hydrochloride is the hydrochloride salt of fasudil, a small-molecule Rho kinase (ROCK) inhibitor used in biochemical and cellular research to probe cytoskeletal dynamics, vascular tone, and related signaling pathways. It is provided as a high-purity solid suitable for laboratory research.
- RhoA/ROCK inhibitor for biochemical and cellular studies.
- CAS number 105628-07-7 and molecular weight 327.83 g/mol.
- Molecular formula C14H18ClN3O2S.
- High purity (~99.97%) suitable for research use.
- Solid, white to off-white appearance; soluble in DMSO and water.
- Recommended storage: 4°C sealed; in solvent: -80°C (1 year) or -20°C (6 months).
- Offered in laboratory pack sizes including 1 g.
Medchemexpress LLC Fasudil hydrochloride | 105628-07-7 | MFCD00943198 | 100.0% | 327.83 g/mol | C14H18ClN3O2S | 100 MG
Fasudil hydrochloride is the hydrochloride salt of fasudil, a nonspecific RhoA/ROCK inhibitor used in research to investigate Rho-kinase-mediated signaling and kinase activity. It has CAS 105628-07-7, molecular formula C14H18ClN3O2S, and a molecular weight of 327.83 g/mol. The compound is supplied as a high-purity research reagent and is soluble in water and DMSO at the concentrations indicated on the product datasheet.
- Nonspecific RhoA/ROCK inhibitor for biochemical and cellular studies.
- Hydrochloride salt form for improved aqueous solubility.
- High purity (99.97%) suitable for research applications.
- Molecular weight 327.83 g/mol; formula C14H18ClN3O2S.
- Solubility: H2O 55 mg/mL (requires ultrasonic), DMSO ≥ 31 mg/mL.
- Intended for research use only; not for human or clinical use.