Aminophenols
Medchemexpress LLC 1-myristoyl-sn-glycero-3-phosphatidylcholine-d7 | 95.4% | 474.62 | 1 MG
LysoPC(14:0/0:0)-d7 is a deuterium labeled lysophospholipid (LyP). It is a monoglycerophospholipid where a phosphorylcholine moiety occupies a glycerol substitution site. This product exhibits a potent antispasmodic effect and is for research use only.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Zymostenol-d7 | 2260669-19-8 | 99.9% | 393.70 | 1 MG
Zymostenol-d7 is deuterium labeled 5a-Cholest-8-en-3b-ol.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuterium substitution has the potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC MRL-494 (hydrochloride) | 2699937-04-5 | 98.6% | 25 MG
MRL-494 hydrochloride is an antibacterial agent that acts as an inhibitor of β-barrel assembly machine A (BamA). It is impervious to efflux and the outer membrane permeability barrier, effectively inhibiting both Gram-positive and Gram-negative bacteria. The agent lethally disrupts the cytoplasmic membrane and inhibits outer membrane protein biogenesis by targeting BamA.
- Impervious to efflux and outer membrane permeability barrier
- Inhibits both Gram-positive and Gram-negative bacteria
- Lethally disrupts cytoplasmic membrane
- Inhibits outer membrane protein biogenesis
Medchemexpress LLC Ikk 16 (hydrochloride) | 1186195-62-9 | 99.9% | 520.09 | 25 MG
IKK 16 hydrochloride is an orally active IKK inhibitor. It also acts as a pan-PKD inhibitor and an ABCB1 inhibitor. This compound protects against LPS-induced multiple organ dysfunction, restores renal function, and alleviates fibrosis in acute kidney injury. It further attenuates cardiac dysfunction associated with polymicrobial sepsis in mice with type 2 diabetes mellitus (T2DM) by inhibiting the NF-κB pathway.
- Acts as an orally active IKK inhibitor
- Functions as a pan-PKD inhibitor
- Inhibits ABCB1
- Protects against LPS-induced multiple organ dysfunction
- Restores renal function and alleviates fibrosis in acute kidney injury
- Attenuates cardiac dysfunction associated with polymicrobial sepsis in mice with type 2 diabetes mellitus
- Inhibits IκB degradation and TNFα-stimulated expression in HUVEC cells
- Inhibits phosphorylation in specific LRRK2 cells
Medchemexpress LLC BIIL-260 hydrochlori | 100MG
BIIL-260 hydrochloride is a potent and long-acting orally active leukotriene B(4) receptor LTB4 antagonist with anti-inflammatory activity BIIL-260 hydrochloride interacts with the LTB4 receptor in a saturable reversible and competitive manner has high affinity to the LTB4 receptor on isolated human neutrophil cell membranes with Ki values of 1 7 nM[1]
Medchemexpress LLC ZZW-115 hydrochloride | 10122-45-9 | 98.1% | 573.97 | 1 ML
ZZW-115 hydrochloride is a potent NUPR1 inhibitor with a Kd of 2.1 μM. It demonstrates anticancer activity by inducing tumor cell death through both necroptosis and apoptosis.
- Potent NUPR1 inhibitor.
- Induces tumor cell death.
- Leads to necroptosis and apoptosis.
- Exhibits anticancer activity.
Medchemexpress LLC CX-6258 hydrochloride hydrate | 1353858-99-7 | 99.2% | 10 MG
A research-grade hydrochloride hydrate salt of a potent pan-Pim kinase inhibitor intended for laboratory research use. It selectively inhibits Pim-1, Pim-2, and Pim-3 with reported IC50 values of 5 nM, 25 nM, and 16 nM, respectively. Characterization data and quality documents (SDS, COA, LCMS) are provided by the supplier.
eMolecules 1219798-53-4 | Medchem Express | Acetaminophen-d7 | 1mg | 784544280 | HY-66005S2 | MFCD08705146 | 158.208 | C8H9NO2
Ambeed | 3-(2-Hexyldecyl)thiophene | 1g | 572971490 | A560834 | 1345699-92-4 | MFCD30489178 | 308.570 | C20H36S
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eMolecules 700-38-9 | 5-Methyl-2-nitrophenol | Ambeed | MFCD00007111 | 153.137 | C7H7NO3 | 98.000 | Cc1ccc(c(O)c1)[N+]([O-])=O | 5g | 525111679
5-Methyl-2-nitrophenol | Ambeed | 700-38-9 | MFCD00007111 | 153.137 | C7H7NO3 | 98.000 | Cc1ccc(c(O)c1)[N+]([O-])=O | 5g | 525111679
Medchemexpress LLC S-14506 hydrochloride | 286369-38-8 | 99.9% | 443.94 | 50 MG
S-14506 hydrochloride | 286369-38-8 | 99.9% | 443.94 | 50 MG
Medchemexpress LLC MT-7716 hydrochloride | 1215859-93-0 | MFCD07778657 | 99.1% | 477.00 | C27H29ClN4O2 | 25 MG
MT-7716 hydrochloride is the hydrochloride salt of MT-7716 (synonym W-212393), a selective non-peptide nociceptin receptor (NOP) agonist investigated as a potential treatment for alcohol abuse and relapse prevention. The compound is supplied as a solid with reported purity 99.06%, molecular formula C27H29ClN4O2, and molecular weight 477.00. It is offered in milligram quantities and as ready-to-use DMSO solutions, and should be stored sealed at 4°C (solutions at -80°C or -20°C per recommended timelines).
- Selective nociceptin receptor (NOP) agonist for receptor pharmacology studies.
- High reported purity (99.06%).
- Available as a solid and as DMSO solutions for ready use.
- Appropriate for preclinical pharmacology and relapse prevention research.
- Store sealed and protected from moisture to maintain stability.
Medchemexpress LLC CC-401 hydrochloride | 1438391-30-0 | 99.35% | 25 MG
CC-401 hydrochloride is a potent inhibitor of all three forms of JNK with Ki of 25 to 50 nM. It exhibits at least 40-fold selectivity for JNK compared with other related kinases, including p38, extracellular signal-regulated kinase (ERK), inhibitor of κB kinase (IKK2), protein kinase C, Lck, and zeta-associated protein of 70 kDa (ZAP70).
- Competitively binds the ATP binding site in JNK.
- Inhibits phosphorylation of the N-terminal activation domain of the transcription factor c-Jun.
- Demonstrates specificity in vitro using osmotic stress of the HK-2 human tubular epithelial cell line.
- Inhibits sorbitol-induced phosphorylation of c-Jun in a dosage-dependent manner.
- Does not prevent sorbitol-induced phosphorylation of JNK, p38, or ERK induced by sorbitol.
- Provides specific JNK inhibition in cell-based assays at 1 to 5 μM.
Medchemexpress LLC PD153035 hydrochloride | 183322-45-4 | 99.5% | 100 MG
PD153035 hydrochloride is the hydrochloride salt of PD153035, a potent and selective epidermal growth factor receptor (EGFR) inhibitor (Ki 6 pM; IC50 25 pM) supplied as an off-white to light yellow solid for laboratory research.
- Potent EGFR inhibitor with Ki 6 pM and IC50 25 pM.
- High purity suitable for research applications.
- Off-white to light yellow solid form.
- Suitable for biochemical and cell-based assays.
- Recommended storage: sealed, away from moisture at 4°C; in solvent: -80°C (six months), -20°C (one month).
Medchemexpress LLC CBL0137 hydrochloride | 1197397-89-9 | 99.7% | 372.89 | 25 MG
CBL0137 hydrochloride is a potent inhibitor of the histone chaperone FACT, known to activate p53 and inhibit NF-κB. It has demonstrated significant activity in vitro, leading to the absence of living cells at concentrations above 2.5 μM, and enhancing the efficacy of gemcitabine in pancreatic cancer cell lines. In vivo studies show it suppresses tumor growth in various xenograft models, including colon, renal cell carcinoma, and melanoma, both as monotherapy and in combination with gemcitabine. This product is intended for research use only.
- Inhibits histone chaperone FACT.
- Activates p53 and inhibits NF-κB.
- Suppresses tumor growth in xenograft models.
- Enhances gemcitabine antitumor activity.
- Suitable for in vitro and in vivo studies in cancer research.
Medchemexpress LLC LCKLSL hydrochloride | 98.1% | 712.34 | 1 MG
LCKLSL hydrochloride is an N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. It potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2, inhibits the generation of plasmin, and has anti-angiogenic roles. In human retinal microvascular endothelial cells (RMVECs), LCKLSL inhibits plasmin generation and suppresses VEGF-induced tPA activity under hypoxic conditions. Application in in vivo models of angiogenesis demonstrates suppression of angiogenic responses.
- Competitive annexin A2 (AnxA2) inhibitor
- Inhibits binding of tissue plasminogen activator (tPA) to AnxA2
- Inhibits generation of plasmin
- Anti-angiogenic roles
- Decreases vascular length in vivo