Aminophenols
Medchemexpress LLC Ozanimod hydrochloride | 1618636-37-5 | 98.1% | 50MG
Ozanimod hydrochloride | 1618636-37-5 | 98.1% | 50MG
Medchemexpress LLC LDC4297 hydrochloride | 2319747-14-1 | 98.2% | 10 MG
LDC4297 hydrochloride is a selective inhibitor of CDK7 with an IC50 value of 0.13 nM. It demonstrates broad antiviral activities against various viruses, including human cytomegalovirus (HCMV) replication with an EC50 value of 24.5 nM. Its antiviral spectrum extends to Herpesviridae, Adenoviridae, Poxviridae, Retroviridae, and Orthomyxoviridae, with EC50 values ranging from 0.02-1.21 μM. This compound is suitable for research related to infection.
- Selective inhibitor of CDK7
- Inhibits human cytomegalovirus (HCMV) replication
- Shows broad antiviral activities against multiple virus families
- Exhibits anti-proliferative activity against human fibroblast primary cultures
- Interferes with virus-induced Rb phosphorylation
- Demonstrates promising pharmacokinetic properties in CD1 mice
Medchemexpress LLC Bi-9627 (hydrochloride) | 1422252-46-7 | 98.01% | 392.80 | 1 ML
BI-9627 hydrochloride is a potent inhibitor of sodium-hydrogen exchanger isoform 1 (NHE1), exhibiting high selectivity over NHE2 and no measurable activity against NHE3. This compound shows low agent-agent interaction potential, excellent pharmacokinetics, and potent activity in isolated heart models of ischemia-reperfusion injury. It is intended for research use only.
- Decreases autophagy in HTR-8/SVneo cells.
- Significantly reduces the pHi of human sperm and partially reverses the effect of DMA.
- Prolongs Ca2+ recovery time in KO hiPSC-CMs.
- Shows low DDI potential.
- Excellent pharmacokinetics in rat and dog.
- Potent activity in isolated heart models of ischemia-reperfusion injury.
Medchemexpress LLC Rhosin (hydrochloride) | 1281870-42-5 | 99.9% | 394.86 | 25 MG
Rhosin hydrochloride is a potent and specific inhibitor of the RhoA subfamily of Rho GTPases. It specifically binds to RhoA to inhibit RhoA-GEF interaction without interacting with Cdc42, Rac1, or the GEF, LARG. This compound induces cell apoptosis and promotes stress resiliency by enhancing D1-MSN plasticity and reducing hyperexcitability.
- Potent and specific inhibitor of the RhoA subfamily of Rho GTPases.
- Specifically binds to RhoA, inhibiting RhoA-GEF interaction.
- Induces cell apoptosis.
- Promotes stress resiliency.
- Reduces RhoA and p-MLC1 activities.
- Prevents social avoidance and blocks sucrose preference deficits.
- Attenuates stress-induced social avoidance and hyperexcitability.
- Enhances spine density in defeat mice.
Medchemexpress LLC SR59230A hydrochloride | 1135278-41-9 | 99.8% | 361.91 g/mol | C21H28ClNO2 | 1 ML
SR59230A hydrochloride is a selective β3-adrenergic receptor antagonist used in research. It penetrates the blood-brain barrier and exhibits nanomolar potency against β-adrenergic receptor subtypes, suitable for in vitro and in vivo pharmacology studies.
- Selective β3-adrenergic receptor antagonist with reported IC50s of 40 nM (β3), 408 nM (β1), and 648 nM (β2)
- Blood-brain barrier penetrating compound suitable for CNS studies
- High purity (≈99.8%) and consistent analytical profile
- Available as a 10 mM solution in DMSO (1 mL) and as solid packs
- Soluble in DMSO (250 mg/mL) and moderately soluble in water (2.5 mg/mL)
- Molecular weight 361.91 g/mol; molecular formula C21H28ClNO2
Medchemexpress LLC Cal-130 hydrochloride | 1431697-78-7 | 98.7% | 462.93 g/mol | C23H23ClN8O | 10 MG
Cal-130 hydrochloride is the hydrochloride salt of a small-molecule inhibitor selective for PI3Kδ (p110δ) and PI3Kγ (p110γ). It is supplied as a solid research reagent and shows low-nanomolar potency against its primary targets, with weaker activity toward other PI3K isoforms.
- Selective inhibition of PI3Kδ and PI3Kγ, low-nanomolar IC50 values
- Demonstrates activity against additional PI3K isoforms at higher concentrations
- High chemical purity suitable for in vitro and preclinical research
- Supplied as a solid, with common pack sizes suitable for laboratory studies
- Provided with documentation that includes molecular formula, molecular weight, and CAS number
Medchemexpress LLC IKK 16 hydrochloride | 1186195-62-9 | 99.95% | 520.09 | 200 MG
IKK 16 hydrochloride | 1186195-62-9 | 99.95% | 520.09 | 200 MG
Medchemexpress LLC UNC2025 hydrochloride | 2070015-17-5 | 100.0% | 513.12 | C28H41ClN6O | 10MM 1ML
UNC2025 hydrochloride is the hydrochloride salt of UNC2025, a potent, ATP-competitive, orally active dual MERTK/FLT3 inhibitor used in preclinical research on acute leukemia and receptor tyrosine kinase signaling. Supplied as a 10 mM solution in DMSO (1 mL), it exhibits sub-nanomolar inhibition of MERTK and FLT3 and demonstrates favorable pharmacokinetic properties for in vitro and in vivo studies.
- Potent MERTK and FLT3 inhibition at sub-nanomolar concentrations.
- Supplied as a ready-to-use 10 mM solution in DMSO for convenient dosing.
- High purity for reproducible experimental results.
- Light yellow to yellow solid appearance when provided as a dry compound.
- Store sealed and protect from moisture; in solution store at -80°C for long-term stability.
Medchemexpress LLC RS100329 hydrochloride | 1215654-26-4 | 99.6% | 462.89 g/mol | C20H26ClF3N4O3 | 25 MG
RS100329 hydrochloride is the hydrochloride salt of RS100329, a potent and selective α1A-adrenoceptor antagonist used in pharmacological research, including studies of urethral reflex contractions and benign prostatic hyperplasia. It is supplied as a solid research chemical with high reported purity and defined storage recommendations.
- Potent, selective α1A-adrenoceptor antagonist (pKi 9.6 for α1A).
- High purity (≈99.6% by HPLC), suitable for biochemical assays.
- Well-characterized small molecule: molecular weight 462.89 g/mol, formula C20H26ClF3N4O3.
- Provided as a solid hydrochloride salt for accurate dosing in experiments.
- Recommended storage: 4°C protected from light; in solvent, -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC R 59-022 (hydrochloride) | 93076-98-3 | MFCD34676749 | 98.9% | 496.04 g/mol | C27H27ClFN3OS | 25 MG
R 59-022 (hydrochloride) is the hydrochloride salt of a small-molecule diacylglycerol kinase inhibitor used for laboratory research. It is provided as an off-white to light yellow solid with molecular formula C27H27ClFN3OS and molecular weight 496.04 g/mol. The compound is reported with high purity and is accompanied by an SDS for safe handling and storage.
- Used as a diacylglycerol kinase inhibitor in biochemical assays.
- High purity (98.9%).
- Molecular weight 496.04 g/mol.
- Formula C27H27ClFN3OS.
- Off-white to light yellow solid appearance for easy visual inspection.
- Supplied in 25 mg research quantities suitable for screening and assay development.
Medchemexpress LLC Ski V | 24418-86-8 | MFCD07772193 | 99.0% | 254.24 g/mol | C15H10O4 | 5 MG
SKI V is a small-molecule sphingosine kinase inhibitor reported to induce apoptosis and exhibit antitumor activity in vitro. The compound is supplied as a powder for laboratory research, with molecular formula C15H10O4 and molecular weight 254.24 g/mol. Solubility and activity data support formulation in DMSO and mixed aqueous vehicles for cell-based studies.
- Inhibits sphingosine kinase and PI3K signaling.
- Demonstrates in vitro activity (IC50 ≈ 2 μM for GST-hSK).
- Reported IC50 values for additional targets provide selectivity context.
- Supplied as a powder suitable for laboratory handling and storage.
- Soluble in DMSO (~50 mg/mL) and formulatable in aqueous vehicles with co-solvents.
- Molecular weight 254.24 g/mol; chemical formula C15H10O4.
- Intended for research use only.
Medchemexpress LLC CC-401 hydrochloride | 1438391-30-0 | 99.35% | 25 MG
CC-401 hydrochloride is a potent inhibitor of all three forms of JNK with Ki of 25 to 50 nM. It exhibits at least 40-fold selectivity for JNK compared with other related kinases, including p38, extracellular signal-regulated kinase (ERK), inhibitor of κB kinase (IKK2), protein kinase C, Lck, and zeta-associated protein of 70 kDa (ZAP70).
- Competitively binds the ATP binding site in JNK.
- Inhibits phosphorylation of the N-terminal activation domain of the transcription factor c-Jun.
- Demonstrates specificity in vitro using osmotic stress of the HK-2 human tubular epithelial cell line.
- Inhibits sorbitol-induced phosphorylation of c-Jun in a dosage-dependent manner.
- Does not prevent sorbitol-induced phosphorylation of JNK, p38, or ERK induced by sorbitol.
- Provides specific JNK inhibition in cell-based assays at 1 to 5 μM.
Medchemexpress LLC CC-401 hydrochloride | 1438391-30-0 | 99.35% | 100 MG
CC-401 hydrochloride is a potent inhibitor of all three forms of JNK, with a Ki ranging from 25 to 50 nM. It demonstrates significant selectivity for JNK over other related kinases and provides specific JNK inhibition in cell-based assays. This compound achieves its effect by competitively binding to the ATP binding site in JNK, thereby inhibiting the phosphorylation of the N-terminal activation domain of c-Jun.
- Potent inhibitor of all three forms of JNK (Ki: 25-50 nM).
- Exhibits at least 40-fold selectivity for JNK compared to other related kinases.
- Provides specific JNK inhibition at concentrations of 1 to 5 μM in cell-based assays.
- Competitively binds the ATP binding site in JNK.
- Inhibits phosphorylation of the N-terminal activation domain of c-Jun.
- Inhibits sorbitol-induced phosphorylation of c-Jun in HK-2 human tubular epithelial cells.
- Slows progression of proteinuria and prevents renal impairment in animal models.
Medchemexpress LLC HLCL-61 hydrochloride | 1158279-20-9 | MFCD09446681 | 99.9% | 380.91 g/mol | C23H25ClN2O | 1 ML
HLCL-61 hydrochloride is a small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) supplied for research use. It is provided as concentrated DMSO stock solutions and as solid material for in vitro and in vivo studies; not for human or veterinary use.
- First-in-class PRMT5 inhibitor for research applications.
- Available as 10 mM stock solutions in DMSO and as solids in multiple sizes.
- High reported purity (approximately 99.9%).
- Soluble in DMSO (≈131 mM at 50 mg/mL) and poorly soluble in water.
- Storage: sealed at 4°C for solids; in solvent -80°C for long-term storage.
- Identifying information: CAS number 1158279-20-9; molecular weight ≈380.91 g/mol.