Aminophenols
Medchemexpress LLC Rgx-104 hydrochloride | 610318-03-1 | 99.9% | 632.54 | 1 MG
RGX-104 hydrochloride is a small-molecule LXR agonist that modulates innate immunity via transcriptional activation of the ApoE gene. It significantly suppresses the growth of multiple cancer types in animals, including lung cancer, melanoma, glioblastoma, ovarian, renal cell, triple-negative breast, and colon cancer, with some instances showing partial or complete tumor regression.
- Small-molecule LXR agonist.
- Modulates innate immunity via transcriptional activation of the ApoE gene.
- Significantly suppresses the growth of multiple cancer types in animals.
- Treatment causes partial or complete tumor regression in some instances.
- Available in solid form and in solution.
Medchemexpress LLC CBB1007 hydrochloride | 2070014-96-7 | C27H39Cl5N8O4 | 50 MG
CBB1007 hydrochloride is a reversible and selective LSD1 inhibitor. It significantly blocks the demethylase activity of LSD1 on H3K4Me2 and H3K4Me, showing selectivity for LSD1 over LSD2 or JARID1A. This compound induces differentiation-related genes in pluripotent cells and is studied in non-pluripotent cancer research, targeting teratocarcinoma, embryonic carcinoma, and seminoma.
- Reversible and selective LSD1 inhibitor
- Blocks demethylase activity of LSD1 on H3K4Me2 and H3K4Me
- Induces differentiation-related genes in pluripotent cells
- Targeted in non-pluripotent cancer research
Medchemexpress LLC CC-115 hydrochloride | 1300118-55-1 | 98.0% | 372.81 | 100 MG
CC-115 hydrochloride is a potent dual DNA-PK and mTOR kinase inhibitor that blocks both mTORC1 and mTORC2 signaling. It inhibits PC-3 cell proliferation and demonstrates selectivity against other protein kinases and PIKKs, including good selectivity against PI3K-alpha, ATR, and ATM. It shows good in vivo PK profiles across multiple species.
- Potent and dual DNA-PK and mTOR kinase inhibitor (IC50s of 13 nM and 21 nM respectively)
- Blocks both mTORC1 and mTORC2 signaling
- Inhibits PC-3 cells proliferation with an IC50 of 138 nM
- Demonstrates selectivity against other protein kinases and PIKKs
- Shows good in vivo PK profiles across multiple species (53% in mouse, 76% in rat, and ~100% in dog oral bioavailability)
- Leads to significant tumor volume reductions and sustains inhibition in vivo
Medchemexpress LLC Rhosin hydrochloride | 1281870-42-5 | 99.9% | 394.86 | 100 MG
Rhosin hydrochloride is a potent and specific inhibitor of the RhoA subfamily of Rho GTPases. It specifically binds to RhoA to inhibit RhoA-GEF interaction and does not interact with Cdc42 or Rac1. This compound induces cell apoptosis and promotes stress resiliency by enhancing D1-MSN plasticity and reducing hyperexcitability.
- Potent and specific RhoA subfamily Rho GTPases inhibitor
- Induces cell apoptosis
- Promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability
- Dose-dependently reduces RhoA and p-MLC1 activities of mammospheres
- Decreases size and reduces number of mammospheres in cells
- Prevents social avoidance and blocks sucrose preference deficits in mice
- Attenuates stress-induced social avoidance
- Blocks stress-induced hyperexcitability in NAc dopamine 1 receptor medium spiny neurons (D1-MSNs)
Medchemexpress LLC CWI1-2 hydrochloride | 2408590-37-2 | C22H18Cl4N6O3 | 5 MG
CWI1-2 hydrochloride is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects.
- IGF2BP2 inhibitor.
- Inhibits IGF2BP2 interaction with m6A-modified target transcripts.
- Induces apoptosis and differentiation.
- Demonstrates anti-leukemic effects.
- Effective in reducing Gln uptake and impairing mitochondrial function in AML cells.
- Inhibits colony-forming ability of leukemic mouse blasts.
- Impairs self-renewal of LSC/LIC.
- Delays leukemia onset and prolongs survival in vivo.
Medchemexpress LLC Guvacine hydrochloride | 6027-91-4 | MFCD00055191 | 99.9% | 163.60 g/mol | C6H10ClNO2 | 1 ML
Guvacine hydrochloride is a GABA transporter inhibitor used in neuroscience research to investigate GABAergic signaling and transporter pharmacology. It is supplied with documented purity, molecular data, and recommended storage conditions to support reliable in vitro experiments.
- Inhibits GABA transporter activity with reported IC50 values for multiple transporter subtypes.
- Supplied as a ready-to-use 10 mM solution in DMSO (1 ML) for immediate use in assays.
- Also available as a solid for custom preparation and long-term storage.
- High reported purity supports reproducible experimental results.
- Storage guidance provided to maintain stability of solid and solution forms.
Medchemexpress LLC Harmine hydrochloride | 343-27-1 | MFCD00078028 | 248.71 | 1 ML
Harmine hydrochloride, also known as Telepathine hydrochloride, is a natural DYRK inhibitor. It exhibits anticancer and anti-inflammatory activities, and has a high affinity for the 5-HT2A serotonin receptor. It is supplied as a solution in DMSO.
- Natural DYRK inhibitor
- Exhibits anticancer and anti-inflammatory activities
- High affinity for 5-HT2A serotonin receptor
- Supplied in solution for convenience
Cayman Chemical N-acetyl-2-AmInophenol 250g
A derivative of acetaminophen; inhibits ADP- or arachidonic acid-induced platelet aggregation in isolated human platelet-rich plasma at 50 µM; decreases disease severity and prevents increases in paw volume in a rat model of collagen-induced arthritis at 1 mg/kg; has been used as a synthetic intermediate in the synthesis of compounds with antimalarial activity; a potential impurity in commercial preparations of acetaminophen
Medchemexpress LLC Afm32a hydrochloride | 2988594-85-8 | 99.7% | 517.00 g/mol | C25H30ClFN6O3 | 5 MG
AFM32a hydrochloride is a benzimidazole-derived small-molecule inhibitor selective for protein arginine deiminase 2 (PAD2). Supplied as the hydrochloride salt for research use, it is suitable for biochemical assays and target validation, demonstrating approximately 95-fold selectivity for PAD2 versus PAD4 and 79-fold versus PAD3.
- Potent PAD2 inhibition with high selectivity over PAD3 and PAD4.
- Hydrochloride salt form for improved solubility and handling.
- High purity (≈99.7%) appropriate for biochemical assays.
- Available in small-mass and DMSO solution formats for screening.
- Characterized with molecular formula and molecular weight for analytical use.
Medchemexpress LLC MELK-8a hydrochloride | 2096992-20-8 | 99.3% | 469.02 g/mol | C25H33ClN6O | 25 MG
MELK-8a hydrochloride is a potent small-molecule inhibitor of maternal embryonic leucine zipper kinase (MELK) with a reported IC50 of 2 nM. Supplied as the hydrochloride salt with high chemical purity, it is intended for research use in biochemical and cellular studies targeting MELK-dependent pathways.
- Potent MELK inhibition with an IC50 of 2 nM.
- Hydrochloride salt for improved stability and handling.
- High purity suitable for biochemical and cellular assays.
- Molecular weight 469.02 g/mol and formula C25H33ClN6O.
- Soluble in DMSO; solution formats available for convenient dosing.
- Intended for research use only; not for human or diagnostic use.
Medchemexpress LLC Zzw-115 hydrochloride | 10122-45-9 | 98.1 % | 573.97 | 5 MG
ZZW-115 hydrochloride is a potent NUPR1 inhibitor with a Kd of 2.1 μM. It induces tumor cell death through necroptosis and apoptosis, demonstrating anticancer activity. It is efficient in killing various cancer cells with IC50 values ranging from 0.42 μM to 4.93 μM. This compound also induces a decrease in ATP production and a ROS overproduction.
- Efficient in killing cancer cells with IC50 values ranging from 0.42 μM to 7.75 μM
- Induces tumor cell death via necroptosis and apoptosis
- Decreases ATP production and induces ROS overproduction
- Inhibits the growth of pancreatic xenografted tumors in vivo
- Demonstrates potent anticancer activity
Medchemexpress LLC Guanine hydrochloride | 635-39-2 | MFCD00213670 | 98.8% | 187.59 | C5H6ClN5O | 100mg
Guanine hydrochloride is one of the fundamental components of nucleic acids (DNA and RNA) It is a purine derivative composed of a fused pyrimidine-imidazole ring system with conjugated double bonds Guanine hydrochloride has the potential to serve as a large-capacity nitrogen reservoir[1]
![Medchemexpress LLC N-(4-hydroxyphenyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide | 901770-40-9 | MFCD29037927 | 99.5% | C16H21N3O3S | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000261035.png-250.jpg)
Medchemexpress LLC N-(4-hydroxyphenyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide | 901770-40-9 | MFCD29037927 | 99.5% | C16H21N3O3S | 10MG
Biotin-4-aminophenol is a biotin-phenol analog used to generate biotinylated protein radicals for selective labeling of tyrosine residues in proteins. Supplied as a solid or as pre-dissolved 10 mM solutions in DMSO, it is intended for biochemical labeling and proteomics workflows where site-selective modification of proteins is required.
- Selective tyrosine labeling via radical-mediated conjugation.
- Efficient generation of biotinylated protein radicals for detection and enrichment.
- Available as solid or 10 mM solution in DMSO for experimental convenience.
- High purity suitable for biochemical and proteomics applications.
- White to off-white solid with good solubility in DMSO.
Medchemexpress LLC Disodium cantharidin | 1465-77-6 | 95.0% | 258.18 g·mol⁻1 | C10H12Na2O5 | 5 MG
Disodium cantharidin is the disodium salt of cantharidin and functions as a selective inhibitor of protein phosphatases PP2A and PP1. Supplied as a solid research reagent (5 mg), it is used in biochemical and cell-based studies to probe phosphatase activity, cell signaling, and apoptosis. For research use only.
- Selective PP2A and PP1 inhibitor, useful for signaling studies.
- Reported activity: PP2A IC50 ≈ 50 nM, PP1 IC50 ≈ 600 nM.
- High purity solid, typically 95% by vendor specification.
- Small package sizes suitable for screening and method development.
- Sodium salt form with formula C10H12Na2O5 and molecular weight 258.18 g·mol⁻1.