Aminophenols

4-(4-Hydroxyphenyl)thiomorpholine 1,1-Dioxide 98.0+%, TCI America™

CAS: 103661-13-8 Molecular Formula: C10H13NO3S Molecular Weight (g/mol): 227.28 MDL Number: MFCD06797109 InChI Key: NSHOLIWPDBJMPT-UHFFFAOYSA-N Synonym: 4-(1,1-Dioxothiomorpholino)phenol, 4-Thiomorpholinophenol 1′C,1′C-Dioxide PubChem CID: 21845223 IUPAC Name: 4-(4-hydroxyphenyl)-1λ⁶-thiomorpholine-1,1-dione SMILES: OC1=CC=C(C=C1)N1CCS(=O)(=O)CC1

Medchemexpress LLC AZD9056 hydrochloride | 345303-91-5 | 98.2% | 455.46 | 5 MG

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Small and/or specialty supplier based on Federal laws and SBA requirements.
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AZD9056 hydrochloride is a selective orally active inhibitor of P2X7 which plays a significant role in inflammation and pain-causing diseases. It is for research use only.

• Selective orally active inhibitor of P2X7
• Plays a significant role in inflammation and pain-causing diseases
• Has a clear inhibitory effect (IC50=1-3 μM) in mouse microglia BV2 cells
• Exerts pain-relieving and anti-inflammatory effects
• Reverses the upregulated expression of interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), matrix metalloproteinase-13 (MMP-13), substance P (SP) and prostaglandin E2 (PGE2) which is induced by MIA in cartilage tissues

Medchemexpress LLC Benzamide, 2-chloro-5-[3-[(3-hydroxypropyl)amino]propyl]-N-(tricyclo[3.3.1.13,7]dec-1-ylmethy-1)- | 345303-91-5 | 98.2% | 455.46 | 25 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

AZD9056 hydrochloride is a selective and orally active inhibitor of P2X7, a receptor that plays a significant role in inflammatory and pain-causing diseases. This compound is intended for research use only.

• Blocks P2X7 receptors with an IC50 of 11.2 nM in HEK-hP2X7 cell lines, demonstrating high selectivity for the P2X7 receptor.
• Exhibits an inhibitory effect (IC50=1-3 μM) in mouse microglia BV2 cells.
• Weakly inhibits BCRP-mediated transport of methotrexate (IC50=92 μM).
• Displays pain-relieving and anti-inflammatory effects.
• Reverses the upregulated expression of interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), matrix metalloproteinase-13 (MMP-13), substance P (SP), and prostaglandin E2 (PGE2) induced by MIA in cartilage tissues.

Medchemexpress LLC AZD9056 hydrochloride | 345303-91-5 | MFCD30533694 | 98.2% | 455.46 | 1 ML

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

AZD9056 hydrochloride is a selective, orally active inhibitor of P2X7, a receptor involved in inflammation and pain-causing diseases. It is for research use only.

• Selectively inhibits P2X7 receptors.
• Exhibits pain-relieving and anti-inflammatory effects.
• Blocks P2X7 receptors with an IC50 of 11.2 nM in HEK-hP2X7 cell line.
• Shows inhibitory effect (IC50=1-3 μM) in mouse microglia BV2 cells.
• Reverses upregulated expression of IL-1β, IL-6, TNF-α, MMP-13, SP, and PGE2 induced by MIA in cartilage tissues.
• Investigated in clinical trials for conditions like rheumatoid arthritis.

Medchemexpress LLC AZD9056 hydrochloride | 345303-91-5 | 98.2% | 455.46 | 50 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

AZD9056 hydrochloride is a selective orally active inhibitor of P2X7, which plays a significant role in inflammation and pain-causing diseases. It is for research use only and not sold to patients.

• Selective orally active inhibitor of P2X7.
• Blocks P2X7 receptors with an IC50 of 11.2 nM in HEK-hP2X7 cell line.
• Exhibits high selectivity for the P2X7 receptor.
• Has an inhibitory effect (IC50=1-3 μM) in mouse microglia BV2 cells.
• Weakly inhibits BCRP-mediated transport of methotrexate (IC50=92 μM).
• Exerts pain-relieving and anti-inflammatory effects in vivo.
• Reverses upregulated expression of IL-1β, IL-6, TNF-α, MMP-13, SP, and PGE2 induced by MIA in cartilage tissues.