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Aminophenols

Organic compounds that consist of a phenol ring with an amino functional group substitution; amino functional groups consist of a nitrogen atom bonded to hydrogen atoms via single bonds.

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Medchemexpress LLC ZM39923 hydrochloride | 1021868-92-7 | MFCD04974534 | 99.8% | 367.91 g/mol | C23H26ClNO | 5MG
SDP

ZM39923 hydrochloride is a research-grade small molecule that acts primarily as a JAK3 inhibitor (pIC50 = 7.1) and also potently inhibits tissue transglutaminase (TGM2) (IC50 ≈ 10 nM). It displays weaker activity against EGFR and JAK1 and minimal activity versus Lck and CDK4. Supplied as the hydrochloride salt with high reported purity, it is intended for laboratory research use only.

  • JAK3 inhibitor with pIC50 7.1.
  • Potent tissue transglutaminase (TGM2) inhibition (IC50 ≈ 10 nM).
  • Hydrochloride salt form for improved stability and handling.
  • High reported purity (around 99.8%).
  • Available as solid and as a DMSO solution format.
  • Intended for research use only; not for diagnostic or therapeutic use.

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2

Medchemexpress LLC 3-(benzyl(isopropyl)amino)-1-(naphthalen-2-yl)propan-1-one hydrochloride | 1021868-92-7 | MFCD04974534 | >98.0% | 367.91 g/mol | C23H26ClNO | 10MM 1ML
SDP

ZM39923 hydrochloride is a small-molecule JAK3 inhibitor used in research. It displays JAK3 potency (pIC50 = 7.1) and also inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM; it is supplied as a 10 mM solution in DMSO and in solid quantities.

  • Small-molecule JAK3 inhibitor (pIC50 = 7.1).
  • Potent TGM2 inhibition (IC50 = 10 nM).
  • Available as 10 mM solution in DMSO and in solid forms.
  • Molecular formula C23H26ClNO.
  • Molecular weight 367.91 g/mol.
  • Purity >98.0% by HPLC.
  • For research use only.

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3

Apexbio Technology LLC XMD8-92 1234480-50-2 10mM (in 1mL DMSO)
SDP

XMD8-92 (CAS 1234480-50-2) is a potent small-molecule inhibitor of mitogen-activated protein kinase 7 (MAPK7/BMK1) demonstrating a Kd of 80 nM and inhibiting EGF-induced BMK1 activation with an IC50 of 240 nM In cellular studies XMD8-92 suppresses proliferation and tumor xenograft growth of cancer cell lines linked to upregulation of tumor-suppressive miRNAs and downregulation of DCLK1 and several oncogenic targets In murine models it impedes the progression of lung and cervical cancer xenografts primarily by affecting cell cycle regulation and angiogenesis XMD8-92 remains under preclinical investigation for its potential in cancer research

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