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Benzenetriols and derivatives

Aromatic organic compounds that consist of a benzene ring with three hydroxyl functional group substitutions. Includes compounds that are derived from benzenetriols.
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1

Sigma Aldrich 6-Chloro-7-hydroxy-5-methyl-2-phenylpyrazolo[1,5-a]-pyrimidine

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

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2

5-Methylpyrogallol 98.0+%, TCI America™

CAS: 609-25-6 Molecular Formula: C7H8O3 Molecular Weight (g/mol): 140.14 MDL Number: MFCD00017501 InChI Key: NYUABOGYMWADSF-UHFFFAOYSA-N Synonym: 3,4,5-Trihydroxytoluene PubChem CID: 587790 IUPAC Name: 5-methylbenzene-1,2,3-triol SMILES: CC1=CC(O)=C(O)C(O)=C1

PubChem CID 587790
CAS 609-25-6
Molecular Weight (g/mol) 140.14
MDL Number MFCD00017501
SMILES CC1=CC(O)=C(O)C(O)=C1
Synonym 3,4,5-Trihydroxytoluene
IUPAC Name 5-methylbenzene-1,2,3-triol
InChI Key NYUABOGYMWADSF-UHFFFAOYSA-N
Molecular Formula C7H8O3
3

eMolecules​ 2 4 6-TRIHYDROXYBENZENE-1 3 5G

5000280230 2 4 6-TRIHYDROXYBENZENE-1 3 5G

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4

Sigma Aldrich Fine Chemicals Biosciences 6-Hydroxydopamine hydrobromide | 636-00-0 | MFCD00012894 | 1g

6-Hydroxydopamine hydrobromide | Purity: 0.95 | MW: 250.09 | 636-00-0 | MFCD00012894 | 1g

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5

Sigma Aldrich Fine Chemicals Biosciences 6-Hydroxydopamine hydrobromide 95% | 636-00-0 | MFCD00012894 | 50MG

6-Hydroxydopamine hydrobromide 95% | Purity: 95% | Mol Wt: 250.09 | 636-00-0 | MFCD00012894 | 50MG

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6

Sigma Aldrich Fine Chemicals Biosciences 6-Hydroxydopamine hydrobromide 95% | 636-00-0 | MFCD00012894 | 5G

6-Hydroxydopamine hydrobromide 95% | Purity: 95% | Mol Wt: 250.09 | 636-00-0 | MFCD00012894 | 5G

ENCOMPASS
7

Sigma Aldrich Fine Chemicals Biosciences 6-Hydroxydopamine hydrobromide 95% | 636-00-0 | MFCD00012894 | 250MG

6-Hydroxydopamine hydrobromide 95% | Purity: 95% | Mol Wt: 250.09 | 636-00-0 | MFCD00012894 | 250MG

ENCOMPASS
8

eMolecules​ 6-HYDROXYDOPAMINE HYDROBROMIDE | 636-00-0 | 1G | Purity: 95%

AstaTech | 6-HYDROXYDOPAMINE HYDROBROMIDE | 1G | 636-00-0 | MFCD00012894

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9

Medchemexpress LLC AT-533 | 908112-37-8 | 98.4% | 410.51 | 50 MG
SDP

AT-533 is a potent inhibitor of Heat Shock Protein 90 (Hsp90) and Herpes Simplex Virus (HSV). It demonstrates anti-tumor and anti-angiogenic properties by targeting the HIF-1α/VEGF/VEGFR-2 signaling pathway, and suppresses downstream pathways including Akt/mTOR/p70S6K, Erk1/2, and FAK.

  • Potent Hsp90 and HSV inhibitor.
  • Suppresses tumor growth and angiogenesis.
  • Inhibits key signaling pathways: Akt/mTOR/p70S6K, Erk1/2, and FAK.
  • Reduces tube formation, cell migration, and invasion in HUVECs.
  • Demonstrates anti-angiogenic activity in CAM models.
  • Decreases inflammatory markers TNF-α, IL-1β, and IL-6.
  • Shows no adverse reactions in subacute toxicology studies.

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10

Medchemexpress LLC AT-533 | 908112-37-8 | 98.38% | 410.51 | 5 MG
SDP

AT-533 is a potent Hsp90 and HSV inhibitor. It suppresses tumor growth and angiogenesis by blocking the HIF-1α/VEGF/VEGFR-2 signaling pathway. Additionally, AT-533 inhibits the activation of downstream pathways such as Akt/mTOR/p70S6K, Erk1/2, and FAK.

  • Inhibits tube formation, cell migration, and invasion of human umbilical vein endothelial cells (HUVECs).
  • Decreases TNF-α, IL-1β, and IL-6 production in RAW264.7 and BV2 cells induced by HSV-1.
  • Shows anti-angiogenic ability in a chorioallantoic membrane (CAM) model.
  • Suppresses the expression of HIF-1α/VEGF signaling pathway-related proteins in MDA-MB-231 breast cancer xenografts in mice.
  • Subacute toxicity tests showed no mortality, loss of appetite, body weight changes, or adverse reactions in Sprague-Dawley rats.

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11

Medchemexpress LLC AT-533 | 908112-37-8 | 98.4% | 410.51 | 100 MG
SDP

AT-533 is a potent Hsp90 and HSV inhibitor. It suppresses tumor growth and angiogenesis by blocking the HIF-1α/VEGF/VEGFR-2 signaling pathway and inhibits the activation of downstream pathways such as Akt/mTOR/p70S6K, Erk1/2, and FAK. Additionally, it inhibits the tube formation, cell migration, and invasion of human umbilical vein endothelial cells (HUVECs).

  • Potent Hsp90 and HSV inhibitor
  • Suppresses tumor growth
  • Inhibits angiogenesis by blocking HIF-1α/VEGF/VEGFR-2 signaling
  • Inhibits Akt/mTOR/p70S6K, Erk1/2, and FAK pathways
  • Inhibits tube formation, cell migration, and invasion of HUVECs
  • Shows anti-angiogenic ability in CAM model
  • Decreases TNF-α, IL-1β, and IL-6 production
  • No significant toxicity in animal studies

ENCOMPASS_PREFERRED
12

SIGMA ALDRICH FINE CHEMICALS BIOSCIENCES 4 5 6-TRIHYDROXYBENZENE-1 3-DI

NC2957929 4 5 6-TRIHYDROXYBENZENE-1 3-DI

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