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Filtered Search Results
Medchemexpress LLC Pardoprunox hydrochloride | 269718-83-4 | 99.5% | 269.73 | 100 MG
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Pardoprunox hydrochloride is a compound that acts as a partial agonist for both dopamine D2 and D3 receptors, and a full agonist for the serotonin 5-HT1A receptor. This compound is intended for research purposes only.
- Partial dopamine D2 and D3 receptor agonist
- Serotonin 5-HT1A receptor agonist
- Acts as a partial D2 receptor agonist with an efficacy of 50%
- Induces [(35)S]GTPgammaS binding as a partial D3 receptor agonist
- Full 5-HT1A receptor agonist on forskolin induced cAMP accumulation
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Medchemexpress LLC COX-1-IN-3 | 20170-32-5 | 99.9% | 278.39 | 50 G
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COX-1-IN-3 (compound 19) is a COX-1 inhibitor with non-steroidal anti-inflammatory activity. It is intended for research use only.
- COX-1 inhibitor
- Non-steroidal anti-inflammatory activity
- High purity (99.95%)
- Available in various quantities and solution formats
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Medchemexpress LLC Dorzolamide (hydrochloride) | 130693-82-2 | 99.9% | C10H17ClN2O4S3 | 250 MG
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Dorzolamide hydrochloride is a potent carbonic anhydrase II inhibitor, with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. It also exhibits anti-tumor activity.
- Potent carbonic anhydrase II inhibitor.
- Possesses anti-tumor activity.
- Effective in retarding the growth of EAC in mice.
- Upregulates TXNIP and p53 while downregulating bcl-2.
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Medchemexpress LLC Risuteganib hydrochloride | 1307293-62-4 | 98.5% | 674.12 | 5 MG
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Risuteganib hydrochloride is a synthetic RGD (arginyl-glycyl-aspartic acid)-class peptide. It acts as an anti-integrin that reduces oxidative stress and restores homeostasis. It targets three integrin receptors involved in dry age-related macular degeneration (AMD) to help restore retinal homeostasis. It is intended for research use only.
- Acts as an anti-integrin
- Reduces oxidative stress and restores homeostasis
- Targets three integrin receptors involved in dry age-related macular degeneration (AMD)
- Intended for research use only
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Ambeed 11bS N NDiethyldinaphtho 2 1d
(11bS)-N,N-Diethyldinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine, 252288-04-3, 98% 99%ee
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Medchemexpress LLC Tetramisole hydrochloride | 5086-74-8 | 99.0% | 1 ML
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Tetramisole hydrochloride | 5086-74-8 | 99.0% | 1 ML
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Ambeed 2 4 Bromomethyl phenyl 4 4 5 5
2-(4-(Bromomethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, 138500-85-3, 97%
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Medchemexpress LLC Desipramine hydrochloride | 58-28-6 | MFCD00058108 | 1 G
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Desipramine hydrochloride acts as an inhibitor for norepinephrine transporter (NET), 5-HT transporter (SERT), and dopamine transporter (DAT). It exhibits Ki values of 4, 61, and 78,720 nM for NET, SERT, and DAT respectively. Studies have shown that chronic administration can reduce NET expression in a dose-dependent manner.
- Inhibitor of norepinephrine transporter (NET)
- Inhibitor of 5-HT transporter (SERT)
- Inhibitor of dopamine transporter (DAT)
- Reduces norepinephrine transporter expression in a dose-dependent manner
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Medchemexpress LLC Relenopride (hydrochloride) | 1221416-42-7 | 99.9% | 529.43 | 25 MG
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Relenopride (hydrochloride) | 1221416-42-7 | 99.9% | 529.43 | 25 MG
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Medchemexpress LLC Gemcitabine hydrochloride (Standard) | 122111-03-9 | 99.94% | C9H12ClF2N3O4 | 50 MG
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Gemcitabine hydrochloride (Standard) is an analytical standard and pyrimidine nucleoside analog antimetabolite. It functions as an antineoplastic agent by inhibiting DNA synthesis and repair, which leads to autophagy and apoptosis. This product is intended for research and analytical applications.
- Reference standard supplied assay
- Commonly used in qualitative research experiments
- Commonly used in quantitative research experiments
- Commonly used in methodological research experiments
- Suitable for HPLC applications
- Suitable for GC applications
- Suitable for MS applications
- Store under recommended conditions in the Certificate of Analysis
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Medchemexpress LLC Gemcitabine Hydrochloride | 122111-03-9 | 99.9% | C9H11F2N3O4 · HCl | 5 G
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Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. It works by inhibiting DNA synthesis and repair, ultimately leading to autophagy and apoptosis.
- Targets DNA synthesis.
- Inhibits the growth of various cancer cell lines, including BxPC-3, Mia Paca-2, PANC-1, PL-45, and AsPC-1.
- Effectively kills both mouse and human senescent cells in vitro.
- Demonstrates increased survival time in mouse models when combined with DMAPT.
- Can be administered via endotracheal spray in rats with lower toxicity compared to oral administration at certain dosages.
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Medchemexpress LLC Pirarubicin (hydrochloride) | 95343-20-7 | 99.1% | 664.10 | 100 MG
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Pirarubicin Hydrochloride is an anthracycline antibiotic that acts as a topoisomerase II inhibitor and is widely used for the treatment of various cancers, particularly solid tumors. This compound induces autophagy in bladder cancer cells in a dose-dependent manner and also induces apoptosis.
- Acts as a topoisomerase II inhibitor
- Widely used for the treatment of various cancers
- Induces autophagy in bladder cancer cells
- Induces apoptosis by inhibiting mTOR/p70S6K/4E-BP1 pathway
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Medchemexpress LLC Ziprasidone hydrochloride | 122883-93-6 | 99.7% | C21H22Cl2N4OS | 50 MG
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Ziprasidone hydrochloride is an orally active combined 5-HT and dopamine receptor antagonist.
- Acts as a 5-HT and dopamine receptor antagonist
- Has high affinity for rat D2, 5-HT2A, and 5-HT1A receptors
- Blocks wild-type hERG current
- Affects weight gain, physical activity, and thermogenesis in vivo
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Medchemexpress LLC Pf-07038124 hydrochloride | 2415317-57-4 | 99.26% | C18H23BClNO4 | 25 MG
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PF-07038124 hydrochloride is a PDE4 inhibitor with an IC50 of 0.5 nM for PDE4B2. It shows inhibitory activities against IL-13, IL4, and IFNγ (IC50=125, 4.1, 1.06 nM, respectively). This compound can be used for research of atopic dermatitis and plaque psoriasis.
- Inhibits PDE4 at 0.5 nM
- Suitable for research of atopic dermatitis and plaque psoriasis
- Has demonstrated inhibitory activities against IL-13, IL4, and IFNγ
- For research use only
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000371494 ILORASERTIB HYDROCH 25MG
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