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Filtered Search Results
Apexbio Technology LLC Carfilzomib (PR-171) 868540-17-4 10mg
Carfilzomib (PR-171 CAS 868540-17-4) is a derivative of the natural product epoxomicin and functions as an irreversible inhibitor of the chymotrypsin-like activity within the 20S proteasome Proteasomes play a critical role in intracellular protein degradation thus inhibition results in accumulation of polyubiquitinated proteins Through this mechanism Carfilzomib induces cell cycle arrest and apoptosis consequently suppressing tumor cell growth Research applications primarily involve exploration of its antitumor efficacy and mechanisms in oncology models
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Apexbio Technology LLC NPS-1034 1221713-92-3 100mg
NPS-1034 (CAS 1221713-92-3) is a potent inhibitor of the receptor tyrosine kinase MET with an IC50 of 4 nmol/L MET activated by hepatocyte growth factor is implicated in morphogenesis and tumor progression across various cancers NPS-1034 suppresses cell viability in MET-overexpressing and phosphorylated MET-positive cell lines such as MKN45 and SNU638 with IC50 values of 112 7 nmol/L and 190 3 nmol/L respectively In vivo oral administration of NPS-1034 reduces tumor growth and angiogenesis in MKN45 xenograft models These characteristics support the utility of NPS-1034 in studying MET-driven oncogenic signaling and its therapeutic targeting
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Apexbio Technology LLC Palonosetron HCl 135729-62-3 10mM (in 1mL DMSO)
Palonosetron hydrochloride (CAS 135729-62-3) is a selective antagonist of the serotonin 5-hydroxytryptamine type 3 (5-HT3) receptor By inhibiting 5-HT3 receptor-mediated signaling on vagal nerve terminals in the gastrointestinal tract and the central nervous system palonosetron attenuates the emetic response triggered by chemotherapeutic agents It is widely utilized in research focused on the mechanisms underlying chemotherapy-induced nausea and vomiting (CINV) as well as in the evaluation of antiemetic interventions targeting serotonergic pathways
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Apexbio Technology LLC Lansoprazole sodium 226904-00-3 10mM (in 1mL Ethanol)
Lansoprazole sodium is a small-molecule inhibitor targeting gastric H /K -ATPase and several human cytochrome P450 (CYP) isoforms including CYP2C9 and CYP2C19 It is designed to inhibit acid secretion by selectively modulating H /K -ATPase activity in parietal cells and to modulate CYP-mediated metabolism pathways Lansoprazole sodium exerts its biological activity primarily through inhibition of its targets In human liver microsome studies it inhibits CYP2C9 and CYP2C19 with Ki values of approximately 21 M and 1 M respectively its inhibitory effect on CYP2D6 and CYP3A4 is weaker with IC values above 200 M Based on these pharmacological properties Lansoprazole sodium holds research potential in the investigation of gastric acid secretion disorders and drug drug interaction profiles involving CYP-mediated metabolism
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Apexbio Technology LLC Sodium Tauroursodeoxycholate (TUDC) 35807-85-3 10mM (in 1mL DMSO)
Sodium tauroursodeoxycholate (TUDC CAS 35807-85-3) is a taurine-conjugated bile salt studied for its modulating effects on cholestasis In human erythrocytes TUDC inhibits bile salt-induced efflux of the fluorochrome BCPCF via MRP1 exhibiting an IC50 of 560 M In vitro TUDC partially reverses 17 -estradiol glucuronide (17 EG)-induced reduction of cholyllysylfluorescein canalicular accumulation suggesting an influence on bile secretion dynamics In rat models of phalloidin-induced cholestasis TUDC administration decreases biochemical markers of liver injury and improves biliary excretion of cholesterol and phospholipids These properties make TUDC relevant for research on hepatoprotection and cholestatic mechanisms
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Apexbio Technology LLC Olopatadine HCl 140462-76-6 10mM (in 1mL DMSO)
Olopatadine HCl (CAS 140462-76-6) is a small molecule antagonist of the histamine H1 receptor classified as a second-generation antihistamine By selectively blocking H1 receptors olopatadine inhibits histamine-mediated inflammatory responses in target tissues Preclinical studies have shown that olopatadine suppresses allergic manifestations such as ear swelling indicating its potential to modulate acute hypersensitivity reactions This compound is widely utilized in research focused on the mechanisms of allergic conjunctivitis and other histamine-dependent allergic disorders
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Apexbio Technology LLC Prilocaine hydrochloride 1786-81-8 5g
Prilocaine hydrochloride (CAS 1786-81-8) is a local anesthetic belonging to the amino amide class It functions by reversibly inhibiting voltage-gated sodium channels on neuronal cell membranes thereby blocking the initiation and propagation of nerve impulses This property makes it suitable for investigating neuronal excitability pain signaling and ion channel pharmacology in various preclinical models Prilocaine hydrochloride is commonly employed in studies requiring local anesthesia and serves as a reference compound for benchmarking novel anesthetic agents in research settings
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Apexbio Technology LLC Tetrahydrozoline HCl 522-48-5 5g
Tetrahydrozoline HCl (CAS 522-48-5) is an imidazoline-based small molecule that functions primarily as an agonist at alpha-adrenergic receptors Activation of these receptors by tetrahydrozoline elicits vasoconstriction via smooth muscle contraction reducing redness and swelling Due to this mechanism tetrahydrozoline hydrochloride is commonly utilized as a research tool to investigate alpha receptor-mediated physiological and pharmacological responses particularly in cardiovascular and ocular experimental models
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Chemscene ChemScene | 4-Amino-3-chlorophenol | 25G | CS-W019864 | 0.98 | 17609-80-2| MFCD00801116 | 143.57
ChemScene | 4-Amino-3-chlorophenol | 25G | CS-W019864 | 0.98 | 17609-80-2| MFCD00801116 | 143.57
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![eMolecules 59255-94-6 | 2-Bromo-3-fluoronitrobenzene | Ambeed | MFCD07782080 | 219.997 | C6H3BrFNO2 | 95.000 | [O-][N+](=O)c1cccc(F)c1Br | 250mg | 552526764](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502426828.PNG-250.jpg)
eMolecules 59255-94-6 | 2-Bromo-3-fluoronitrobenzene | Ambeed | MFCD07782080 | 219.997 | C6H3BrFNO2 | 95.000 | [O-][N+](=O)c1cccc(F)c1Br | 250mg | 552526764
2-Bromo-3-fluoronitrobenzene | Ambeed | 59255-94-6 | MFCD07782080 | 219.997 | C6H3BrFNO2 | 95.000 | [O-][N+](=O)c1cccc(F)c1Br | 250mg | 552526764
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Accela Chembio Inc 3 | 5-dibromo-4-hydroxybenzoic Acid | 100g | 3337-62-0 | MFCD00002548 | 97+% | Shelf Life: 1440 Days | Light Sensitive
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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3 | 5-dibromo-4-hydroxybenzoic Acid | 100g | 3337-62-0 | MFCD00002548 | 97+% | Shelf Life: 1440 Days | Light Sensitive
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eMolecules 1940-28-9 | 4-Bromo-3,5-dichlorophenol | Combi-Blocks | MFCD01830114 | 241.890 | C6H3BrCl2O | 97.000 | Oc1cc(Cl)c(Br)c(Cl)c1 | 1g | 342886257
4-Bromo-3,5-dichlorophenol | Combi-Blocks | 1940-28-9 | MFCD01830114 | 241.890 | C6H3BrCl2O | 97.000 | Oc1cc(Cl)c(Br)c(Cl)c1 | 1g | 342886257
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eMolecules 1032231-24-5 | 2-Bromo-5-iodobenzaldehyde | Ambeed | MFCD07779027 | 310.916 | C7H4BrIO | 97.000 | Brc1ccc(I)cc1C=O | 250mg | 490535830
2-Bromo-5-iodobenzaldehyde | Ambeed | 1032231-24-5 | MFCD07779027 | 310.916 | C7H4BrIO | 97.000 | Brc1ccc(I)cc1C=O | 250mg | 490535830
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eMolecules EMOLECULES INC
509426822 LEVOMEFOLATE CALCIUM 5G
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eMolecules EMOLECULES INC
509426821 LEVOMEFOLATE CALCIUM 25G
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