Carboxylic acid amides
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Cayman Chemical mP-2 InhIbItr I 5mg
A copper-containing compound with diverse biological activities inhibits ferroptotic cell death induced by RSL3 erastin or iron(II) (EC50s 134 169 and 171 nM respectively) as well as RSL3- erastin- or iron-induced lipid peroxidation in N27 rat mesencephalic cells at 1 UM increases SOD1G37R protein levels metalation and activity in the spinal cord in the SOD1G37R transgenic mouse model of ALS at 30 mg/kg per day increases the number of a-motor neurons and reduces oxidatively modified proteins in the spinal cord as well as increases the latency to fall in the rotarod test in the same ALS mouse model versions containing positron-emitting copper isotopes have been used in PET imaging applications for selective labeling of hypoxic tissue
