Carboxylic acid imides

Medchemexpress LLC 3-[5-[4-(2-hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(CF3)phenyl]-4-(indol-3-yl)-pyrrole-2,5-dione | 1260181-14-3 | 99.5% | 526.51 g·mol-1 | C27H25F3N4O4 | 1 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

TCS 21311 is a small-molecule inhibitor of Janus kinase 3 (JAK3) used as a biochemical and pharmacological tool. It exhibits potent enzymatic activity (IC50 ≈ 8 nM) and strong selectivity for JAK3 over JAK1, JAK2, and TYK2, making it suitable for studies of JAK3-mediated signaling.

• Potent JAK3 inhibition with an IC50 of approximately 8 nM.
• Greater than 100-fold selectivity versus JAK1, JAK2, and TYK2.
• Well-defined molecular properties: C27H25F3N4O4, molecular weight 526.51 g·mol-1.
• High purity suitable for research use (~99.5% by HPLC).
• Supplied in small-quantity packaging ideal for screening and biochemical assays.

Medchemexpress LLC 3-[5-[4-(2-hydroxy-2-methylpropanoyl)piperazin-1-yl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)pyr | 1260181-14-3 | MFCD19380092 | 99.5% | 526.51 | C27H25F3N4O4 | 10 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

TCS 21311 is a small-molecule research compound that potently and selectively inhibits JAK3 and exhibits additional activity against GSK-3 and PKC isoforms, intended for in vitro and preclinical research use.

• Potent JAK3 inhibition (IC50 8 nM).
• Secondary activity against GSK-3β and PKC isoforms (IC50s 3-68 nM).
• High chemical purity (~99.5%).
• Molecular weight 526.51 g/mol; formula C27H25F3N4O4.
• Available in small-mass formats and DMSO solution for ready reconstitution.

Medchemexpress LLC 3-[5-[4-(2-hydroxy-2-methylpropanoyl)piperazin-1-yl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)pyrrole-2,5-dione | 1260181-14-3 | MFCD19380092 | 99.5% | 526.51 g/mol | C27H25F3N4O4 | 5 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

TCS 21311 (NIBR3049) is a research-stage small molecule that potently and selectively inhibits Janus kinase 3 (JAK3). It is used in biochemical and cellular studies to probe JAK3-dependent signaling pathways and has reported activity against PKC and GSK-3β.

• Selective JAK3 inhibitor with IC50 approximately 8 nM.
• Also inhibits PKC and GSK-3β, useful for kinase profiling.
• High purity (99.5%) suitable for biochemical assays.
• Solid form, white to yellow, with defined storage stability.
• Supplied in small milligram quantities for research applications.