Tricarboxylic acids and derivatives
Medchemexpress LLC Tos-PEG3-CH2COOH | 1581248-63-6 | 50 MG
Tos-PEG3-CH2COOH is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These PROTACs feature two distinct ligands connected by a linker: one targets an E3 ubiquitin ligase, and the other binds to a specific target protein. This mechanism allows PROTACs to exploit the intracellular ubiquitin-proteasome system for the selective degradation of target proteins. This product is for research use only.
- PEG-based PROTAC linker
- Used for PROTAC synthesis
- Leverages ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Sigma Aldrich Fine Chemicals Biosciences Sodium citrate dihydrate >=99%, FG | 6132-04-3 | MFCD00150031 | 25KG
Sodium citrate dihydrate >=99%, FG | Purity: >=99% | Mol Wt: 294.1 | 6132-04-3 | MFCD00150031 | 25KG
Alkali Scientific Citric Acid, Monohydrate, (ACS Grade), 25 Kg
Citric Acid Monohydrate (ACS Grade, 25 Kg) is a high-purity, laboratory-grade reagent commonly used in the preparation of buffers, solutions, and as an acidulant in chemical synthesis. The ACS-grade product ensures precise quality and reliability, making it ideal for use in pharmaceutical, biochemical, and industrial applications. Citric Acid Monohydrate is widely used for its buffering capacity in maintaining a stable pH in various biochemical assays and processes. This 25 Kg packaging is perfect for large-scale laboratories and industrial applications, providing both convenience and cost-efficiency for long-term reagent supply needs.
Medchemexpress LLC Peg3-o-ch2cooh (protac linker 8) | 51951-05-4 | ≥95.0% | 50 MG
PEG3-O-CH2COOH (PROTAC Linker 8) is a PEG-based PROTAC linker primarily used in the synthesis of SNIPERs. It can also be utilized as PROTAC linker (Compound 15b) in the synthesis of SNIPER(ER)s. These SNIPERs are designed to recruit inhibitor of apoptosis protein (IAP) ubiquitin ligases for the specific degradation of targeted proteins. This product is intended for research use only and is not for patient treatment.
- PEG-based PROTAC linker
- Used in the synthesis of SNIPERs
- Utilized as PROTAC linker (Compound 15b) in the synthesis of SNIPER(ER)s
- Recruits inhibitor of apoptosis protein (IAP) ubiquitin ligases
- Facilitates specific degradation of targeted proteins
- For research use only
Medchemexpress LLC COR659 | 544450-68-2 | 99.9% | 337.82 | 50 MG
COR659 is a potent and effective GABAB positive allosteric modulator (PAM). It suppresses alcohol and chocolate self-administration in rats. It appears to act through a composite mechanism, including positive allosteric modulation of the GABAB receptor and an action at the cannabinoid CB1 receptor.
- Potent and effective GABAB positive allosteric modulator (PAM).
- Suppresses alcohol and chocolate self-administration in rats.
- Effective in reducing lever-responses for sucrose and chocolate solutions in rats.
- In vivo studies indicate no effect on lever-responding for regular food pellets in food-deprived Wistar rats.
- Demonstrates a dose-dependent reduction in lever-responses for alcohol in rats.
Medchemexpress LLC L-Aspartic acid, N-(phosphonoacetyl)-, trisodium salt | 70962-66-2 | 98.0% | 321.06 | 10 MG
Sparfosic acid trisodium is a DNA antimetabolite agent and a potent inhibitor of aspartate transcarbamoyl transferase, which catalyzes the second step of de novo pyrimidine biosynthesis. It synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines. It is for research use only and not sold to patients.
- DNA antimetabolite agent
- Potent inhibitor of aspartate transcarbamoyl transferase
- Synergistically enhances the cytotoxicity of 5-FU and IFN against human colon cancer cell lines
- Treatment with 490 mg/kg in mice bearing B16 melanoma increased life-span by 77% to 86%
- Lewis lung carcinoma is highly sensitive, with treatment leading to a cure in 50% of mice
Electron Microscopy Sciences Ammonium Water 0.3% 500 ML
Used in Ehrlich's Hematoxylin , Mallory (1938); Ehrlich (1886), Nuclei.
![eMolecules 68-04-2 | Sodium citrate, anhydrous | Oakwood Chemical | MFCD00012462 | 258.068 | C6H5Na3O7 | 99.000 | [Na+].[Na+].[Na+].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O | 25g | 866847505](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000470643.jpg-250.jpg)
eMolecules 68-04-2 | Sodium citrate, anhydrous | Oakwood Chemical | MFCD00012462 | 258.068 | C6H5Na3O7 | 99.000 | [Na+].[Na+].[Na+].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O | 25g | 866847505
Sodium citrate, anhydrous | Oakwood Chemical | 68-04-2 | MFCD00012462 | 258.068 | C6H5Na3O7 | 99.000 | [Na+].[Na+].[Na+].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O | 25g | 866847505
Sigma Aldrich Fine Chemicals Biosciences Trisodium citrate dihydrate meets USP testing specifications | 6132-04-3 | MFCD00150031 | 25KG
Trisodium citrate dihydrate meets USP testing specifications | Purity: 99.0-100.5% anhydrous basis | Mol Wt: 294.1 | 6132-04-3 | MFCD00150031 | 25KG
Medchemexpress LLC Citrate synthase | 9027-96-7 | ~98 KDa dimer (49 KDa monomer) | 1000 U
Citrate synthase catalyzes the initial reaction of the citric acid cycle, facilitating the condensation of acetyl-CoA and oxaloacetate to produce citrate. This enzyme is primarily found within the mitochondrial matrix of eukaryotic cells.
- Catalyzes the condensation of acetyl-CoA and oxaloacetate
- Forms citrate, initiating the citric acid cycle
- Localized in the mitochondrial matrix of eukaryotic cells
- Specific activity of ≥100 U/mg protein
- Unit defined as 1.0 μmole of citrate formed per minute at pH 8.0 at 37°C
- Liquid appearance
- Colorless to light yellow
- Molecular weight of ~98 KDa dimer (49 KDa monomer)
Medchemexpress LLC Acetic acid, 2-[2-(2-azidoethoxy)ethoxy]- | 882518-90-3 | 99.03% | 189.17 | 50 MG
Azido-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Azide group that can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. This product is for research use only.
- Peg-based PROTAC linker
- Click chemistry reagent
- Contains an Azide group for CuAAc and SPAAC reactions
Medchemexpress LLC Acetic acid, 2-[2-(2-azidoethoxy)ethoxy]- | 882518-90-3 | 99.0% | 189.17 | 100 MG
Azido-PEG2-CH2COOH is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It can also engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- Functions as a click chemistry reagent
- Contains an azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
- Engages in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
Apexbio Technology LLC Pentoxyverine Citrate 23142-01-0 10mM (in 1mL DMSO)
Pentoxyverine Citrate (CAS 23142-01-0) is a small-molecule antagonist targeting acetylcholine receptors (AChR) including 1 and 2 receptors It acts by inhibiting central and peripheral cholinergic pathways thereby regulating neural control of cough reflex sensitivity Pentoxyverine Citrate exerts its biological activity primarily through suppression of the cough reflex via modulation of sensory nerve pathways It demonstrates antitussive anticonvulsant and antispasmodic activity with K i values of 41 nM for 1 894 nM for 2 and 75 nM for 1 receptors in guinea pig brain membrane models Based on these pharmacological properties Pentoxyverine Citrate holds research potential in studies of cough physiology cholinergic neurotransmission and therapeutic interventions in respiratory conditions