Tricarboxylic acids and derivatives
Medchemexpress LLC Amino-PEG3-CH2COOH | 134978-99-7 | 99.9% | C8H17NO5 | 100 MG
Amino-PEG3-CH2COOH is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker, with one targeting an E3 ubiquitin ligase and the other targeting the protein of interest. This mechanism exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Diphosphoric acid, mono[(2E)-4-hydroxy-3-methyl-2-butenyl] ester, triammonium salt | 443892-56-6 | 90.0% | C5H21N3O8P2 | 500 UG
HDMAPP triammonium is a potent phosphoantigen in the ammonium and pyrophosphate form of (E)-HDMAPP. It is an activator of γδ T cells and can induce T cell stimulation in vitro with an EC₅₀ of 0.39 nM for TNF-α release.
- Potent phosphoantigen
- Activates γδ T cells
- Induces T cell stimulation in vitro
- Increases TNF-α release in human Vγ9Vδ2 T cells
- Significantly increases γδ cells in cynomolgus monkey model
- White to off-white solid appearance
Medchemexpress LLC Tos-PEG3-CH2COOH | 1581248-63-6 | 250 MG
Tos-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Contains two different ligands connected by a linker
- Suitable for cancer targeted therapy research
Medchemexpress LLC (E/Z)-Zotiraciclib citrate | 1204918-73-9 | C29H32N4O8 | 50 MG
(E/Z)-Zotiraciclib citrate is a potent inhibitor targeting CDK2, JAK2, and FLT3. This compound is supplied as a solid, appearing off-white to light yellow, and is intended for research use only.
- Potent CDK2, JAK2, and FLT3 inhibitor
- High purity: 99.83%
- Molecular weight: 564.59
- Store at 4°C, sealed, away from moisture
N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(F)c(F)cc1F | 25g | 624127118](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502171601.JPG-250.jpg)
eMolecules 654671-77-9 | SITAGPLIPTIN PHOSPHATE MONOHYDRATE | AstaTech | MFCD10001393 | 523.329 | C16H20F6N5O6P | 99.000 | O.OP(O)(O)=O.N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(F)c(F)cc1F | 25g | 624127118
SITAGPLIPTIN PHOSPHATE MONOHYDRATE | AstaTech | 654671-77-9 | MFCD10001393 | 523.329 | C16H20F6N5O6P | 99.000 | O.OP(O)(O)=O.N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(F)c(F)cc1F | 25g | 624127118
Medchemexpress LLC DMAPP (triammonium) | 1186-30-7 | 95.0% | 1 MG
DMAPP (Dimethylallyl diphosphate) triammonium is an isoprenoid precursor found in virtually all life forms. It is an isomer of isopentenyl pyrophosphate (IPP) and plays a role in both the mevalonate and MEP pathways of isoprenoid precursor biosynthesis. The enzyme isopentenyl pyrophosphate isomerase catalyzes the isomerization between DMAPP and IPP.
- Isoprenoid precursor
- Isomer of isopentenyl pyrophosphate (IPP)
- Found in virtually all life forms
- Product of mevalonate and MEP pathways
- Involved in isoprenoid precursor biosynthesis
- Isomerization catalyzed by isopentenyl pyrophosphate isomerase
Accela Chembio Inc Triethyl Methanetricarboxylate | 25g | 6279-86-3 | MFCD00009150 | 95+% | D: 1.095 | Shelf Life: 1080 Days | Regular
Triethyl Methanetricarboxylate | 25g | 6279-86-3 | MFCD00009150 | 95+% | D: 1.095 | Shelf Life: 1080 Days | Regular
Medchemexpress LLC Pacritinib (citrate) | 1228923-42-9 | 99.7% | 664.70 | 1 ML
Pacritinib (SB1518) citrate is a potent inhibitor of both wild-type JAK2 (IC50=23 nM) and JAK2V617F mutant (IC50=19 nM). It also inhibits FLT3 (IC50=22 nM) and its mutant FLT3D835Y (IC50=6 nM). This compound can be used for the research of acute myeloid leukemia (AML) and myelofibrosis (MF).
- Potent inhibitor of wild-type JAK2 (IC50=23 nM)
- Potent inhibitor of JAK2V617F mutant (IC50=19 nM)
- Inhibits FLT3 (IC50=22 nM)
- Inhibits FLT3D835Y mutant (IC50=6 nM)
- Used for research in acute myeloid leukemia (AML) and myelofibrosis (MF)
Alkali Scientific L (+) Rhamnose, Monohydrate, 500 G
L (+) Rhamnose Monohydrate is a high-purity sugar used in laboratory applications, especially in studies of bacterial metabolism and plant biology. This 500-gram supply is ideal for experiments requiring a consistent and reliable source of rhamnose. It is commonly used in biochemical assays, microbiological testing, and as a substrate in fermentation processes. The monohydrate form ensures accurate and reproducible results in laboratory experiments. Rhamnose is used in research on plant cell wall metabolism, microbial growth studies, and other applications where precise sugar control is critical. This bulk quantity is perfect for continuous research and experimental work.
eMolecules 29949-81-3 | Tris(4-bromophenyl)phosphane | MFCD02690473 | 250mg
Ambeed | (S)-2-Amino-3-(7-chloro-1H-indol-3-yl)propanoic acid | 100mg | 525092784 | A175659 | 73945-46-7 | MFCD09264322 | 238.670 | C11H11ClN2O2
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Teknova 20mM Sodium Citrate, 8% Sucrose, pH 6.0. 500mL, Endotoxin Tested, Sterile. 8 pack.
20mM Sodium Citrate, 8% Sucrose, pH 6.0. 500mL, Endotoxin Tested, Sterile. 8 pack.
Medchemexpress LLC Boc-NH-PEG1-CH2COOH | 142929-49-5 | 98.0% | C9H17NO5 | 1 G
Boc-NH-PEG1-CH2COOH is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Molecular weight: 219.23
- Appearance: Solid-liquid mixture
- Color: Colorless to light yellow
- SMILES: O=C(O)COCCNC(OC(C)(C)C)=O
- Storage (pure form): -20°C for 3 years, 4°C for 2 years
- Storage (in solvent): -80°C for 6 months, -20°C for 1 month
- Solubility (in vitro): DMSO at 100 mg/mL (456.14 mM)
- Solubility (in vivo): Protocols available for DMSO, PEG300, Tween-80, Saline, SBE-β-CD, and Corn Oil
eMolecules 1447947-87-6 | 2,4,6-Tris(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1,3,5-triazine | 1g
Medchem Express | Lisuride (maleate) | 5mg | 713704305 | HY-110080 | 19875-60-6 | MFCD28166478 | 454.527 | C24H30N4O5
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Medchemexpress LLC DiMal-O-CH2COOH | 1620837-47-9 | 96.8% | 308.24 | C13H12N2O7 | 10 MG
This cleavable linker is designed for use in antibody-drug conjugate (ADC) construction and conjugation workflows, offering malemide-based chemistry for attaching payloads to antibodies or targeting moieties. It is provided at research-grade purity and supplied in small quantities suitable for method development and exploratory studies.
- Cleavable linker for ADC construction and conjugation workflows.
- Provides maleimide-based chemistry for reliable payload attachment.
- High purity (96.8%) suitable for research applications.
- Available in small research quantities; larger amounts available on request.
- Store at 4°C, protect from light; in solvent: -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Tamoxifen (Citrate) | 54965-24-1 | 99.9% | 563.64 | 1 ML
Tamoxifen Citrate is an orally active, selective estrogen receptor modulator (SERM) that blocks estrogen action in breast cells while activating estrogen activity in other cells like bone, liver, and uterine cells. It functions as a potent Hsp90 activator, enhancing its molecular chaperone ATPase activity. Additionally, it can inhibit infectious EBOV Zaire and Marburg (MARV).
- Selective estrogen receptor modulator
- Blocks estrogen action in breast cells
- Activates estrogen activity in bone, liver, and uterine cells
- Potent Hsp90 activator
- Enhances Hsp90 molecular chaperone ATPase activity
- Inhibits infectious EBOV Zaire and Marburg (MARV)
- Activates autophagy
- Induces apoptosis
- Used to induce gene knockout in CreER transgenic mice