Tricarboxylic acids and derivatives
Medchemexpress LLC Tos-peg3-ch2cooh | 1581248-63-6 | 100 MG
Tos-PEG3-CH2COOH is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. PROTACs are molecules that leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins. They consist of two different ligands connected by a linker; one ligand binds to an E3 ubiquitin ligase, and the other binds to the target protein, facilitating its degradation.
- Utilizes the ubiquitin-proteasome system for selective protein degradation.
- Acts as a linker in the construction of degraders.
Medchemexpress LLC Dicresulene diammoni 10mg | 10MG
Dicresulene diammonium is an impurity of Policresulen an organic acid with hemostatic antimicrobial and antiviral activities[1 [2
Medchemexpress LLC Arl67156 trisodium hydrate | 99.9% | 834.61 | C15H23Br2N5Na3O13P3 | 5 MG
ARL67156 trisodium hydrate is the trisodium hydrate salt form of ARL67156, a selective small-molecule inhibitor of ecto-ATPase enzymes including NTPDase1 (CD39), NTPDase3, and NPP1. Supplied as a white to off-white solid, it is intended for research use in studies of purinergic signaling, inflammation, and cardiovascular or respiratory disease models.
- Selective inhibitor of ecto-ATPase enzymes, including NTPDase1 (CD39), NTPDase3, and NPP1.
- Reported Kis values in the low micromolar range for primary targets.
- Demonstrated activity in cellular and tissue assays such as potentiation of neurogenic contractions and modulation of neurotransmitter release.
- High reported purity (99.94%), suitable for biochemical and cellular research.
- Supplied as a solid, white to off-white, available in small research quantities.
Alkali Scientific Citric Acid, Monohydrate, (ACS Grade), 25 Kg
Citric Acid Monohydrate (ACS Grade, 25 Kg) is a high-purity, laboratory-grade reagent commonly used in the preparation of buffers, solutions, and as an acidulant in chemical synthesis. The ACS-grade product ensures precise quality and reliability, making it ideal for use in pharmaceutical, biochemical, and industrial applications. Citric Acid Monohydrate is widely used for its buffering capacity in maintaining a stable pH in various biochemical assays and processes. This 25 Kg packaging is perfect for large-scale laboratories and industrial applications, providing both convenience and cost-efficiency for long-term reagent supply needs.
Apexbio Technology LLC Tandospirone citrate 112457-95-1 5mg
Tandospirone citrate (CAS 112457-95-1) is a selective partial agonist of the 5-HT1A receptor exhibiting high affinity for this target (Ki 27 nM) while demonstrating markedly lower affinity for other receptors such as 5-HT2 5-HT1C 1 2 D1 and D2 (Ki 1300 41000 nM) In vitro tandospirone citrate shows the strongest binding to 5-HT1A receptors In vivo studies indicate it reduces premature responses in a dose-dependent manner suggesting an inhibitory effect on impulsive behavior Tandospirone citrate is utilized as a pharmacological tool in research on depression anxiety and other neuropsychiatric conditions
Medchemexpress LLC Fmoc-NH-PEG6-CH2COOH | 437655-96-4 | 99.4% | 561.62 | C29H39NO10 | 25 MG
Fmoc-NH-PEG6-CH2COOH is an Fmoc-protected PEG6 linker with a terminal carboxylic acid used as a hydrophilic spacer for conjugation chemistry. It is commonly used in antibody-drug conjugate (ADC) and PROTAC synthesis to provide a soluble linker and a protected amine for further derivatization.
- Cleavable PEG-based linker suitable for ADC and PROTAC synthesis.
- Provides an Fmoc-protected amine and a terminal carboxylic acid for conjugation.
- Molecular weight 561.62 and formula C29H39NO10.
- Purity 99.37% as reported by the supplier.
- Soluble in DMSO at 100 mg/mL; may require sonication.
- Storage: pure form -20 °C (3 years) or 4 °C (2 years); in solvent -80 °C (6 months) or -20 °C (1 month).
- Available in small lab pack sizes, including 25 mg.
Medchemexpress LLC Peg3-o-ch2cooh (protac linker 8) | 51951-05-4 | ≥95.0% | 50 MG
PEG3-O-CH2COOH (PROTAC Linker 8) is a PEG-based PROTAC linker primarily used in the synthesis of SNIPERs. It can also be utilized as PROTAC linker (Compound 15b) in the synthesis of SNIPER(ER)s. These SNIPERs are designed to recruit inhibitor of apoptosis protein (IAP) ubiquitin ligases for the specific degradation of targeted proteins. This product is intended for research use only and is not for patient treatment.
- PEG-based PROTAC linker
- Used in the synthesis of SNIPERs
- Utilized as PROTAC linker (Compound 15b) in the synthesis of SNIPER(ER)s
- Recruits inhibitor of apoptosis protein (IAP) ubiquitin ligases
- Facilitates specific degradation of targeted proteins
- For research use only
Medchemexpress LLC COR659 | 544450-68-2 | 99.9% | 337.82 | 50 MG
COR659 is a potent and effective GABAB positive allosteric modulator (PAM). It suppresses alcohol and chocolate self-administration in rats. It appears to act through a composite mechanism, including positive allosteric modulation of the GABAB receptor and an action at the cannabinoid CB1 receptor.
- Potent and effective GABAB positive allosteric modulator (PAM).
- Suppresses alcohol and chocolate self-administration in rats.
- Effective in reducing lever-responses for sucrose and chocolate solutions in rats.
- In vivo studies indicate no effect on lever-responding for regular food pellets in food-deprived Wistar rats.
- Demonstrates a dose-dependent reduction in lever-responses for alcohol in rats.
Medchemexpress LLC L-Aspartic acid, N-(phosphonoacetyl)-, trisodium salt | 70962-66-2 | 98.0% | 321.06 | 10 MG
Sparfosic acid trisodium is a DNA antimetabolite agent and a potent inhibitor of aspartate transcarbamoyl transferase, which catalyzes the second step of de novo pyrimidine biosynthesis. It synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines. It is for research use only and not sold to patients.
- DNA antimetabolite agent
- Potent inhibitor of aspartate transcarbamoyl transferase
- Synergistically enhances the cytotoxicity of 5-FU and IFN against human colon cancer cell lines
- Treatment with 490 mg/kg in mice bearing B16 melanoma increased life-span by 77% to 86%
- Lewis lung carcinoma is highly sensitive, with treatment leading to a cure in 50% of mice