Imidazoles
Medchemexpress LLC M-89 | 2363165-42-6 | 99.1% | 10 MG
M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin. M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to study MLL leukemia. M-89 inhibits the cell growth in leukemia cell lines carrying MLL fusion.
- Inhibits the cell growth of MV4-11 cell line with an IC50 of 25 nM.
- Inhibits the cell growth of HL-60 cell line with an IC50 of 10.2 μM.
- Stabilized the cellular menin protein in both MV4-11 and MOLM-13 cells dose-dependently (3.7-300 nM).
- Induces a time- and dose-dependent apoptosis in MV4-11 cells (0.03-3 μM, 48 h).
Medchemexpress LLC M-89 | 2363165-42-6 | 99.1% | 50 MG
M-89 is a highly potent and specific menin inhibitor that targets the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction. It has potential for studying MLL leukemia by inhibiting cell growth in leukemia cell lines and inducing apoptosis. It is for research use only.
- Highly potent and specific menin inhibitor
- Inhibits menin-MLL protein-protein interaction
- Potential for studying MLL leukemia
- Inhibits cell growth in leukemia cell lines carrying MLL fusion
- Induces time- and dose-dependent apoptosis in MV4;11 cells
- Stabilizes cellular menin protein in MV4;11 and MOLM-13 cells
Medchemexpress LLC M-89 | 2363165-42-6 | 99.1% | 657.87 g/mol | C37H47N5O4S | 5 MG
M-89 is a potent, selective menin-MLL interaction inhibitor supplied as a research compound for preclinical biochemical and cellular studies. It is used to disrupt the menin-MLL protein-protein interaction in epigenetic and leukemia research.
- Potent menin-MLL protein-protein interaction inhibitor (Kd 1.4 nM).
- High purity (99.1%) suitable for biochemical assays.
- Soluble in DMSO at approximately 7.35 mg/mL with ultrasonic assistance.
- Available in small research quantities for exploratory studies.
- Stable when stored as powder at low temperatures for long-term use.
eMolecules 2-Amino-5-fluoro-N-phenylbenzamide | 60041-89-6 | MFCD11101521 | 1g
Ambeed | 2-Amino-5-fluoro-N-phenylbenzamide | 1g | 490552334 | A306740 | | 60041-89-6 | MFCD11101521 | 230.242 | C13H11FN2O
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