Imidazoles

Medchemexpress LLC Sec61-IN-1 | 2484865-42-9 | >99.7% | 430.53 | 50 MG

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Sec61-IN-1 is a potent sec61 inhibitor that effectively targets glioma cells and enhances T cell cytotoxic effects. It demonstrates efficacy in vitro by enhancing T cell cytotoxicity in U87 glioma cells and shows lower IC50 values in specific PDX cell lines. In vivo, it is detected in mouse brain tissue following intravenous injection, indicating potential for various research applications.

• Potent sec61 inhibitor
• Effectively targets glioma cells
• Enhances T cell cytotoxic effects in U87 glioma cells
• Lower IC50 for cytotoxicity in GBM12 and GBM38 PDX cell lines with SEC61G-EGFR dual amplification
• Detected in mouse brain tissue 45 min after intravenous injection

Medchemexpress LLC Contezolid (MRX-I) | 1112968-42-9 | 99.2% | 408.33 | 50 MG

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Contezolid (MRX-I) | 1112968-42-9 | 99.2% | 408.33 | 50 MG

Medchemexpress LLC Sec61-IN-1 (compound A317) | 2484865-42-9 | 99.7% | C23H22N6OS | 10MG

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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Sec61-IN-1 (compound A317) is a small-molecule inhibitor of the Sec61 translocon developed for research use. It selectively inhibits Sec61-mediated protein translocation, shows cytotoxic activity in certain glioma models, and can enhance T cell-mediated cytotoxicity in vitro; it also shows measurable brain exposure in mouse studies. Supplied as a solid or as a DMSO solution for laboratory studies.

• Potent Sec61 inhibition in vitro.
• Enhances T cell-mediated cytotoxicity against glioma cells.
• Demonstrated activity in SEC61G-EGFR amplified glioblastoma models.
• Detectable brain exposure after intravenous dosing in mice.
• Available as solid and as a DMSO solution for formulation flexibility.
• High purity suitable for research (99.7%).
• Recommended storage conditions provided to preserve stability.

Medchemexpress LLC Sec61-IN-1 (compound A317) | 2484865-42-9 | 99.7% | 430.53 g/mol | C23H22N6OS | 5 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Sec61-IN-1 (compound A317) is a small-molecule inhibitor of the Sec61 translocon used as a research tool to study protein translocation and Sec61-mediated pathways. Manufacturer documentation reports molecular formula C23H22N6OS, molecular weight 430.53 g/mol, and purity of 99.7%. The compound has been reported to target glioma cells and to enhance T cell cytotoxic effects in experimental studies.

• High purity (99.7%) suitable for research use.
• Selective inhibition of Sec61-mediated protein translocation.
• Reported activity against glioma cells and enhancement of T cell cytotoxicity.
• Supplied as a five mg vial for small-scale in vitro or in vivo preparation.
• Includes supporting documentation: data sheet, certificate of analysis, and safety data sheet.

eMolecules​ Medchem Express / Sec61-IN-1 / 5mg / 719836848 / HY-139615 / / 2484865-42-9 / [null] / 430.530 / C23H22N6OS

Medchem Express / Sec61-IN-1 / 5mg / 719836848 / HY-139615 / / 2484865-42-9 / [null] / 430.530 / C23H22N6OS