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Filtered Search Results
Selleck Chemical LLC GGTI 298 TFA salt
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GGTI 298 is a geranylgeranyltransferase I inhibitor with ability to arrest human tumor cells in the G1 phase of the cell cycle and induce apoptosis
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Medchemexpress LLC (4-(Thiazol-2-ylcarbamoyl)piperidine-1-carbonyl)-L-leucine | 1814897-92-1 | 99.6% | 368.45 | 5 MG
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This chemical compound, (4-(Thiazol-2-ylcarbamoyl)piperidine-1-carbonyl)-L-leucine, is designed for laboratory use and the manufacture of substances. It is stable under recommended storage conditions and offers high purity.
- High purity of 99.64%
- Suitable for laboratory applications
- Stable under recommended storage conditions
- Not classified as a hazardous substance or mixture
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Medchemexpress LLC Di(adamantan-1-yl)phosphine | 131211-27-3 | 98.0% | 302.43 | 1 G
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Di(adamantan-1-yl)phosphine, also known as Di-1-adamantylphosphine, is a biological molecule classified as a biochemical assay reagent. It is intended for research use only.
- Solid appearance
- White to off-white color
- Chemical formula: C20H31P
- Ships at room temperature in continental US
- Store at 4°C, protected from light and under nitrogen
- When in solvent, store at -80°C for 6 months or -20°C for 1 month, protected from light and under nitrogen
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eMolecules 4,5-Dimethylthiazol-2-amine hydrochloride | 71574-33-9 | MFCD00012711 | 1g
Oakwood Chemical | 4,5-Dimethylthiazol-2-amine hydrochloride | 1g | 537714270 | 209385 | | 71574-33-9 | MFCD00012711 | 164.650 | C5H9ClN2S
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Medchemexpress LLC 4-methylphenyl 1-thio-β-D-glucopyranoside | 1152-39-2 | MFCD11045365 | 99.0% | 286.34 g/mol | C13H18O5S | 5 G
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4-Methylphenyl 1-thio-β-D-glucopyranoside is a thioglycoside reagent for glycobiology research, commonly used as a substrate in enzymatic assays and studies of glycan recognition. Supplied as a purified white crystalline solid for research and analytical applications (not for human use).
- Used as a substrate for glycosidase and glycosyltransferase assays.
- High purity suitable for analytical and biochemical research.
- White crystalline solid with molecular formula C13H18O5S.
- CAS number 1152-39-2 for unambiguous identification.
- Available in multiple pack sizes including 5 G for lab-scale experiments.
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Medchemexpress LLC Met kinase-IN-2 | 2101241-90-9 | 98.4% | C33H27FN4O4 | 10MG
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MET kinase-IN-2 is a potent, selective, orally bioavailable inhibitor of the MET (c-Met/HGFR) receptor tyrosine kinase. It inhibits MET with an IC50 of 7.4 nM, shows antitumor activity in cell-based assays, and has reported activity against several additional kinases and tumor cell lines. Supplied as a solid research chemical for laboratory use.
- Potent MET kinase inhibition (IC50 = 7.4 nM).
- Orally bioavailable, enabling in vivo studies.
- Demonstrated antitumor activity in cell assays.
- Shows additional kinase activity at higher concentrations.
- High-purity solid suitable for research applications.
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Medchemexpress LLC S-methyl-KE-298 | 143584-75-2 | MFCD31382145 | 98.0% | 252.33 g/mol | C13H16O3S | 10 MG
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S-methyl-KE-298 is the active metabolite of KE-298 reported to inhibit matrix metalloproteinase-1 (MMP-1) production in rheumatoid arthritis synovial cells. Supplied as a solid research chemical, it is intended for in vitro studies and characterization and is provided with defined purity and storage conditions.
- Active metabolite of KE-298.
- Inhibits MMP-1 production in rheumatoid arthritis synovial cells.
- High purity (98.0%).
- Solid, white to off-white appearance.
- Molecular formula C13H16O3S; molecular weight 252.33 g/mol.
- Recommended storage conditions for powder and for solutions.
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eMolecules Pharmablock / 8-chloronaphthalen-1-amine / 1g / 551281881 / PBT1788 / 0.000 / 59107-51-6 / MFCD00465087 / 177.630 / C10H8ClN
Pharmablock / 8-chloronaphthalen-1-amine / 1g / 551281881 / PBT1788 / 0.000 / 59107-51-6 / MFCD00465087 / 177.630 / C10H8ClN
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Apexbio Technology LLC TH-302 918633-87-1 50mg
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TH-302 (CAS 918633-87-1) is a hypoxia-activated prodrug comprising a 2-nitroimidazole moiety linked to a brominated isophosphoramide mustard Under severe hypoxic conditions (approximately 0 1% O ) TH-302 undergoes bioreductive activation releasing the cytotoxic alkylating agent Br-IPM selectively within hypoxic tumor microenvironments In vitro studies demonstrate markedly increased cytotoxicity against tumor cell lines under hypoxia with IC50 values ranging from 0 1 to 0 8 M for H460 Caki-1 SK-MEL-5 DU145 and HCT116 cells while IC50 values exceed 40 M in normoxic conditions In H460 xenograft mouse models TH-302 induces dose-dependent tumor growth inhibition without hematological toxicity and increases H2AX-positive cells indicating DNA damage TH-302 is utilized to investigate tumor hypoxia-targeting therapies and mechanisms of selective cytotoxicity
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BIOHIPPO AAV-TH-3XFlag-WPRE-hGH-polyA
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Recombinant adeno associated virus expressing 3XFlag under the TH promoter with WPRE and hGH polyA elements. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.
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eMolecules 2-hydroxy-2-(4-methylthiazol-2-yl)propanehydrazide | 1251929-90-4 | | 250mg
WuXi AppTec | 2-hydroxy-2-(4-methylthiazol-2-yl)propanehydrazide | 250mg | 589800095 | LN02196654 | | 1251929-90-4 | | 201.240 | C7H11N3O2S
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Medchemexpress LLC (2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone | 141627-42-1 | 99.6% | C20H19NO5 | 5 G
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(2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone is a drug intermediate used for the synthesis of various active compounds. It is for research use only and not sold to patients.
- Purity of 99.59%
- Physical form: Solid
- Color: Yellow to brown
- Store powder at -20°C for 3 years or 4°C for 2 years
- Store in solvent at -80°C for 6 months or -20°C for 1 month
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Apexbio Technology LLC Cytochrome c fragment (93-108) 25mg
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Cytochrome c fragment 93-108 is a peptide derived from cytochrome c a mitochondrial protein involved in apoptosis It is designed to interact with apoptotic protease activating factor-1 (Apaf-1) thereby promoting the assembly of the Apaf-1/caspase-9 apoptosome complex and regulating the caspase activation pathway Cytochrome c fragment 93-108 exerts its biological activity primarily through activation of the caspase cascade specifically the activation of caspase-9 and subsequent caspase-3 Based on these pharmacological properties cytochrome c fragment 93-108 holds research potential in studies of apoptosis-related signaling networks caspase activation pathways and drug screening targeting apoptosis regulators
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Medchemexpress LLC Yl-5092 | 3056857-07-6 | 99.8% | 441.43 | C22H14F3N3O2S | 10 MG
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YL-5092 is a selective inhibitor of YT521-B homology (YTH) domain-containing protein 1 (YTHDC1) with potent biochemical activity and demonstrated efficacy in acute myeloid leukemia models. It is used in research probing m6A-mediated RNA regulation and cancer biology, and is supplied as a characterized, high-purity solid for in vitro and in vivo studies.
- Selective inhibition of YTHDC1 (IC50 7.4 nM; KD 29.6 nM).
- Demonstrated cellular activity against AML cell lines and efficacy in xenograft models.
- Induces G0/G1 phase arrest and apoptosis in cancer cells.
- High reported purity and defined physicochemical properties for reproducible results.
- Soluble in DMSO (100 mg/mL) and formulatable for in vivo use (≥2.5 mg/mL in standard vehicle).
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Medchemexpress LLC 4-[2-(2-fluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyridine | 1784751-19-4 | MFCD29924749 | 99.9% | 333.33 g/mol | C20H13F2N3 | 50 MG
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TA-02 is a small-molecule p38 MAPK inhibitor used in biochemical and cell-based research. As an analog of SB 203580, it exhibits potent activity (IC50 ≈ 20 nM) and preferential inhibition of TGFBR-2. The compound is supplied as a high-purity solid suitable for laboratory studies involving kinase signaling modulation.
- Potent p38 MAPK inhibition (IC50 ≈ 20 nM).
- Preferential inhibition of TGFBR-2.
- High purity solid suitable for research applications.
- Compact pack sizes available for small-scale studies.
- Molecular weight ~333.33 g/mol; formula C20H13F2N3.
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