Thiazoles
Cayman Chemical 2-amIno-4- 1-adamntyl ThIaz 1g
An isoprostane induces calcium influx in HEK293 cells expressing human TRPA1 and isolated mouse trigeminal neurons at 100 UM potentiates glutamate-induced cytotoxicity and decreases GSH levels in HT22 hippocampal cells at 1 and 30 UM respectively inhibits VEGF-induced migration and tube formation of human coronary artery endothelial cells at 10 UM an effect that can be reversed by SQ 29548
Cayman Chemical 2-methyl-4-phenyl ThIazole 1g
A CysLT1 receptor antagonist (Ki 2 1 nM in a radioligand binding assay using isolated human lung membranes) inhibits contractions induced by LTD4 or LTE4 in histamine-primed isolated guinea pig trachea (pA2 9 4 and 9 1 respectively) but not contractions induced by LTC4 in histamine-primed isolated guinea pig trachea at 190 nM inhibits LTD4-induced calcium mobilization in COS-7 cells expressing the human CysLT1 receptor at 100 nM improves tissue damping and elasticity markers of lung function and decreases IL-4 and IL-5 levels in BALF in a mouse model of ovalbumin-induced asthma at 5 mg/kg