Thiazoles

Apexbio Technology LLC KN-93 139298-40-1 25mg

KN-93 (CAS 139298-40-1) is a selective inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKII) a serine/threonine kinase activated by calcium-bound calmodulin KN-93 inhibits CaMKII enzymatic activity with reported IC50 values of approximately 0 37 0 5 M in vitro and a Ki value of 2 58 M against cardiac CaMKII In NIH 3T3 cells KN-93 (12 M) induces G1 cell-cycle arrest and at higher concentrations (24 M) promotes apoptosis Due to CaMKII s role in neuronal function cardiac signaling immune activation and disease states including Alzheimer s and arrhythmias KN-93 serves as a tool compound for studying CaMKII-mediated processes in biomedical research

Cayman Chemical 2-amIno-4- 1-adamntyl ThIaz 1g

An isoprostane induces calcium influx in HEK293 cells expressing human TRPA1 and isolated mouse trigeminal neurons at 100 UM potentiates glutamate-induced cytotoxicity and decreases GSH levels in HT22 hippocampal cells at 1 and 30 UM respectively inhibits VEGF-induced migration and tube formation of human coronary artery endothelial cells at 10 UM an effect that can be reversed by SQ 29548

Cayman Chemical 2-methyl-4-phenyl ThIazole 1g

A CysLT1 receptor antagonist (Ki 2 1 nM in a radioligand binding assay using isolated human lung membranes) inhibits contractions induced by LTD4 or LTE4 in histamine-primed isolated guinea pig trachea (pA2 9 4 and 9 1 respectively) but not contractions induced by LTC4 in histamine-primed isolated guinea pig trachea at 190 nM inhibits LTD4-induced calcium mobilization in COS-7 cells expressing the human CysLT1 receptor at 100 nM improves tissue damping and elasticity markers of lung function and decreases IL-4 and IL-5 levels in BALF in a mouse model of ovalbumin-induced asthma at 5 mg/kg