Acyloins

Sigma Aldrich 7-(4-Bromobenzyl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

Sigma Aldrich 2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)ethanethioamide

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

Sigma Aldrich 2,3,4-Trihydroxybenzaldehyde

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

Sigma Aldrich 2,3-Dimethylbenzoic acid

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

Sigma Aldrich Acetoin

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

Medchemexpress LLC Tisolagiline monomethylsulfate | 1894207-45-4 | 99.8% | 50 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Tisolagiline methylsulfate (KDS2010) is a selective, reversible, and orally active inhibitor for MAO-B with an IC50 of 8 nM. It exhibits neuroprotective and anti-neuroinflammatory activities.

• Selective, reversible, and orally active MAO-B inhibitor
• Exhibits neuroprotective and anti-neuroinflammatory activities
• Reduces expression of glial fibrillary acidic protein (GFAP)
• Ameliorates MPTP-induced Parkinson's disease in mouse models
• Inhibits astrocyte scar formation

Medchemexpress LLC Tisolagiline monomethylsulfate | 1894207-45-4 | 99.8% | 10 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

Tisolagiline monomethylsulfate (KDS2010) is a selective, reversible, and orally active inhibitor for MAO-B with an IC50 of 8 nM. It exhibits neuroprotective and anti-neuroinflammatory activities. It reduces glial fibrillary acidic protein (GFAP) expression and glycosaminoglycan (CSPGs) deposition, thereby inhibiting astrocyte activation and scar formation.

• Ameliorates MPTP-induced Parkinson's disease in mouse models, alleviating motor dysfunction.
• Reverses reduction in TH-positive neurons and reduces GFAP and iNOS expression.
• Inhibits astrocyte scar formation.
• Increases doxorubicin penetration into glioblastoma domains and glioblastoma tumor volume in mouse models.

Medchemexpress LLC Tisolagiline monomethylsulfate | 1894207-45-4 | 99.8% | 100 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

Tisolagiline methylsulfate is a selective, reversible, and orally active inhibitor for MAO-B with an IC50 of 8 nM. It exhibits neuroprotective and anti-neuroinflammatory activities. This product is for research use only and is not sold to patients.

• IC50 & target: MAO-B: 8 nM (IC50)
• In vitro: At 1 μM for 4 days, it inhibits astrocyte activation and scar formation by reducing glial fibrillary acidic protein (GFAP) and glycosaminoglycans (CSPGs) expression.
• In vivo: In MPTP-induced Parkinson's disease mouse models, it ameliorates motor dysfunction and reduces GFAP/iNOS expression. In U87 MG xenograft models, it inhibits astrocyte scar formation, enhancing Doxorubicin penetration and increasing glioblastoma (GBM) tumor volume.