HP-Silica phase is made of activated hydroxyl (-OH) functional group with the pore size selection of 120 Å and particle size selection of 1.8, 3, 5, and 10 µm. Carbon loading is 0.0%. HP-Silica is used as the normal phase as well as HILIC phase. HP-Silica phases are suitable for separations of polar and basic organic compounds, such as vitamins, steroids, as well as pharmaceuticals.