The Silica-C™ HPLC Columns are made with Cogent TYPE-C™ Silica, and provide unique Selectivity due to its surface chemistry (especially in Normal Phase HPLC) compared to standard silica, This Silica Hydride Phase is not modified and therefore has no end-capping or organic ligands.Chosen for analyzing large compounds that are not soluble in Water including but not limited to: lipids, peptides, proteins, oligonucleotides and other compounds that require non polar solvents. Faster Equilibration than other Silica Columns, no need to control moisture in Mobile Phase Solvents, robust Column Lifetimes. This column is often chosen for use macro-molecules such as proteins and polysaccharides in HPLC using UV detection or in LCMS with a flow splitter.