ELISA Substrates and Reagents
Kingfisher Biotech Inc Ferret CCL8 ELISpot - Up to two (2) ELISpot assays
Ferret CCL8 ELISpot contains Capture Antibody, Standard Control, and Detection Antibody for development of up to two (2) ELISpot assays. Other required materials and reagents are not supplied. The antibodies have been determined to function in an ELISpot with the Standard Control provided. Components may also be purchased separately. For research use only. Made in the USA
Kingfisher Biotech Inc Human LIF ELISpot - Up to two (2) ELISpot assays
Human LIF ELISpot contains Capture Antibody, Standard Control, and Detection Antibody for development of up to two (2) ELISpot assays. Other required materials and reagents are not supplied. The antibodies have been determined to function in an ELISpot with the Standard Control provided. Components may also be purchased separately. For research use only. Made in the USA
Cayman Chemical Hedgehog ntagonIst VIII 10mg
A cell-permeable quinazolinyl-urea compound that has been shown to inhibit Gli transcription activity (IC50 = 70 nM)
ABclonal Technology Phospho-TIFA-T9 Rabbit pAb
This gene encodes an adapter protein involved in adaptive and innate immunity. This protein includes a forkhead-associated (FHA) domain that specifically binds to phosphorylated serine and threonine residues. In response to bacterial infection, the encoded host cell protein undergoes an intermolecular interaction between the FHA domain and a phosphorylated threonine that leads to protein oligomerization and stimulation of the NF-kappa B and other downstream signaling pathways. This protein exhibits reduced expression in hepatocellular carcinoma and may suppress hepatocellular carcinoma progression. This protein may also play a role in the DNA damage response.
ABclonal Technology Decorin Rabbit pAb
This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients.
ABclonal Technology Phospho-STK3/MST2-T117 Rabbit pAb
This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology Phospho-MEK1-T292 Rabbit pAb
The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.
Sigma Aldrich Fine Chemicals Biosciences SuperoseR 6 Prep Grade HiL
HiLoad 16/600 Superose 6 prep grade (pg) is a prepacked size exclusion chromatography (SEC) column for high-resolution purification of large biomolecules and protein complexes. The column is an excellent choice for purification of sample volumes up to 5 mL..nbspConvenience and reproducibility can be used with standalone pump or a chromatography system..nbspHigh-resolution separations purification is possible across an exceptionally broad molecular-weight range..nbspScalable separations can be scaled up using Superose 6 prep grade resin..nbspÄKTA system compatible fittings (1/16) for direct connection to ÄKTA systems and other chromatography systems.Selectivity for a wide range of proteinsThis column is packed with Superose 6 pg resin which provides good resolution separations of proteins and other biomolecules according to size. The wide fractionation range of the resin enables reproducible and robust separations in the molecular weight range from 5000 up to 5 000 000.
ABclonal Technology Phospho-Axl-Y702 Rabbit pAb
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. The encoded protein acts as a host cell receptor for multiple viruses, including Marburg, Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus.
ABclonal Technology Phospho-TP73-Y99 Rabbit pAb
This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined.