ELISA Substrates and Reagents
ABclonal Technology WNK1 Rabbit pAb
This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.
Hanna Pharmaceutical Supply Co., Inc. HANNAS PHARMACEUTICAL SUPPLY CO INC
NC4031798 SOLUTION SET WITH DUO-VENT
ABclonal Technology Phospho-HSP27/HSPB1-S15 Rabbit pAb
This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy.
Medchemexpress LLC Phospho-AKT(S473) Antibody (YA5759) | 56 kDa | 100 UL
Phospho-AKT(S473) Antibody (YA5759) is a mouse-derived, non-conjugated monoclonal antibody targeting Phospho-AKT(S473). AKT protein is crucial in regulating cellular processes like metabolism, proliferation, cell survival, growth, and angiogenesis, functioning through serine and/or threonine phosphorylation of numerous downstream substrates.
- Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
- Stored at -20°C for 1 year
- Avoid repeated freeze/thaw cycles
- Shipping with blue ice
- Suitable for WB, IHC-P, and ICC/IF applications
ABclonal Technology Phospho-NF-kB p65/RelA-S536 Rabbit pAb
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.
Genscript Corporation 4-1BB/TNFRSF9 hFc ChimeraBiot
4-1BB is also known as CD137 is a type 2 transmembrane glycoprotein receptor belonging to the TNF superfamily CD137 can be expressed by activated T cells but to a larger extent on CD8 than on CD4 T cells In addition CD137 expression is found on dendritic cells B cells follicular dendritic cells natural killer cells granulocytes and cells of blood vessel walls at sites of inflammation
ABclonal Technology p-RPS6-S235/236
Ribosomes the organelles that catalyze protein synthesis consist of a small 40S subunit and a large 60S subunit Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit The protein belongs to the S6E family of ribosomal proteins It is the major substrate of protein kinases in the ribosome with subsets of five C-terminal serine residues phosphorylated by different protein kinases Phosphorylation is induced by a wide range of stimuli including growth factors tumor-promoting agents and mitogens Dephosphorylation occurs at growth arrest The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA As is typical for genes encoding ribosomal proteins there are multiple processed pseudogenes of this gene dispersed through the genome
Cayman Chemical Limonin 17-β-D-Glucopyranoside, Purity: ≥95%, CAS: 123564-61-4, 1 mg
A furanolactone with anticancer activity; induces apoptosis and disrupts the mitochondrial membrane potential in SW480 cells at 100 µM; inhibits the proliferation of MDA-Panc-28 cells (IC50 = 20.49 µM)
Miltenyi Biotec, Inc. aTGF-b RII-VioBright R720,h, REA903, 30t
Identification and enumeration of TGF-β RII+ cells by flow cytometry.
This product is subject to the following: Miltenyi Biotec, Inc. Terms and Conditions of Sale For Products and Services
ABclonal Technology Phospho-Akt-S473 Rabbit pAb
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]