Protein Molecular Weight Markers
ABclonal Technology EML2 Rabbit pAb
Enables microtubule binding activity. Involved in negative regulation of microtubule polymerization and regulation of microtubule nucleation. Colocalizes with mitotic spindle.
ABclonal Technology CDC25B Rabbit mAb
CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist.
ABclonal Technology STXBP1 Rabbit mAb
This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described.
ABclonal Technology FHIT Rabbit mAb
The protein encoded by this gene is a P1-P3-bis(5-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage.
Biotium Primary Antibody Human IgG Fc N2508.HFC CF583R 1/EA
Anti-Human IgG (Fc) rVHH (N2508 HFC) is a recombinant Alpaca VHH antibody that recognizes the Fc domain of human IgG and is validated for IF and flow Red fluorescent STORM-compatible CF583R dye has Ex/Em at 583/606 nm Unit size 500 uL at 0 1 mg/mL
ABclonal Technology COPG2 Rabbit pAb
Predicted to enable structural molecule activity. Involved in intra-Golgi vesicle-mediated transport. Part of COPI vesicle coat.
ABclonal Technology HUS1 Rabbit pAb
The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants.
ABclonal Technology AK7 Rabbit pAb
This gene encodes a member of the adenylate kinase family of enzymes. The encoded enzyme is a phosphotransferase that catalyzes the reversible phosphorylation of adenine nucleotides. This enzyme plays a role in energy homeostasis of the cell. Alternative splicing results in multiple transcript variants. Mutations in the mouse gene are associated with primary ciliary dyskinesia.
ABclonal Technology MYH4 Rabbit pAb
Enables double-stranded RNA binding activity. Involved in muscle contraction. Located in myofibril.
ABclonal Technology NGDN Rabbit pAb
Neuroguidin is an EIF4E (MIM 133440)-binding protein that interacts with CPEB (MIM 607342) and functions as a translational regulatory protein during development of the vertebrate nervous system (Jung et al., 2006 [PubMed 16705177]).
ABclonal Technology PPL Rabbit pAb
The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.
ABclonal Technology Raptor Rabbit pAb
This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology RABL3 Rabbit pAb
Predicted to enable GTP binding activity, GTPase activity, and protein homodimerization activity. Involved in regulation of Ras protein signal transduction and regulation of protein lipidation. Predicted to be active in endomembrane system. Implicated in pancreatic cancer.
ABclonal Technology COQ10B Rabbit pAb
Predicted to enable ubiquinone binding activity. Predicted to be involved in cellular respiration and ubiquinone biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion.
ABclonal Technology GPX2 Rabbit pAb
The protein encoded by this gene is a member of the glutathione peroxidase family, which reduces organic hydroperoxides and hydrogen peroxide (H2O2) using glutathione, protecting cells from oxidative damage. This isozyme is mainly expressed in the gastrointestinal tract and liver (in humans), localized in the cytoplasm, and prefers hydrogen peroxide as its substrate. Overexpression is linked to increased differentiation and proliferation in colorectal cancer. It is also a selenoprotein, with selenocysteine (Sec) at its active site, encoded by the UGA codon. The 3 UTR of selenoprotein mRNAs contains a stem-loop structure called the SECIS element, essential for interpreting UGA as Sec, not a stop codon. Alternative splicing variants of this gene have been identified.