Protein Molecular Weight Markers
ABclonal Technology MAN1A2 Rabbit pAb
Alpha-mannosidases function at different stages of N-glycan maturation in mammalian cells. See MAN2A1 (MIM 154582) for general information.
ABclonal Technology FNTB Rabbit pAb
Enables zinc ion binding activity. Contributes to protein farnesyltransferase activity. Involved in protein farnesylation. Part of microtubule associated complex and protein farnesyltransferase complex.
ABclonal Technology SLC31A1 Rabbit pAb
The protein encoded by this gene is a high-affinity copper transporter found in the cell membrane. The encoded protein functions as a homotrimer to effect the uptake of dietary copper.
ABclonal Technology SEMA4F Rabbit pAb
This gene encodes a transmembrane class IV semaphorin family protein, which plays a role in neural development. This gene may be involved in neurogenesis in prostate cancer, the development of neurofibromas, and breast cancer tumorigenesis. Alternative splicing results in multiple transcript variants.
ABclonal Technology PSMC5 Rabbit pAb
The 26S proteasome is a multicatalytic proteinase complex consisting of a 20S core and a 19S regulator. The 20S core has 4 rings made of 28 subunits, while the 19S regulator includes a base with ATPase subunits and a lid with non-ATPase subunits. Proteasomes, located throughout eukaryotic cells, cleave peptides in an ATP/ubiquitin-dependent process. The immunoproteasome processes class I MHC peptides. This gene encodes an ATPase subunit, part of the triple-A family of ATPases with chaperone-like activity. Beyond proteasome function, it may also participate in transcriptional regulation, interacting with thyroid hormone and retinoid X receptors. Two isoforms of this gene are produced by alternative splicing.
ABclonal Technology HPS4 Rabbit pAb
This gene encodes a protein component of biogenesis of lysosome-related organelles complexes (BLOC). BLOC complexes are important for the formation of endosomal-lysosomal organelles such as melanosomes and platelet dense granules. Mutations in this gene result in subtype 4 of Hermansky-Pudlak syndrome, a form of albinism. Alternative splicing results in multiple transcript variants.
ABclonal Technology BRE Rabbit pAb
This gene encodes an anti-apoptotic, death receptor-associated protein that interacts with tumor necrosis factor-receptor-1. The encoded protein acts as an adapter in several protein complexes, including the BRCA1-A complex and the BRISC complex. The BRCA1-A complex possesses ubiquitinase activity and targets sites of double strand DNA breaks, while the BRISC complex exhibits deubiquitinase activity and is involved in mitotic spindle assembly. This gene is upregulated in several types of cancer.
ABclonal Technology HDAC9 Rabbit pAb
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined.
![ABclonal Technology [KO Validated] CHRAC1 Rabbit pAb](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000105257.jpg-250.jpg)
ABclonal Technology [KO Validated] CHRAC1 Rabbit pAb
CHRAC1 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.
ABclonal Technology ZNF621 Rabbit pAb
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.
ABclonal Technology XPO7 Rabbit pAb
The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex, see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors.
ABclonal Technology RUSC1 Rabbit pAb
Predicted to enable actin binding activity. Involved in protein polyubiquitination. Located in cytosol.
ABclonal Technology CARD14 Rabbit pAb
This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants.
ABclonal Technology GLYAT Rabbit pAb
The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoAs. Two transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology EMC1 Rabbit pAb
This gene encodes a single-pass type I transmembrane protein, which is a subunit of the endoplasmic reticulum membrane protein complex (EMC). Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.