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Medchemexpress LLC ZD-4190 10mM 1mL | 1mL
ZD-4190 is a potent orally available inhibitor of the vascular endothelial cell growth factor receptor 2 (VEGFR2) and of epidermal growth factor receptor (EGFR) signalling used for the treatment of cancer
Medchemexpress LLC ZD-0892 | 171964-73-1 | 95.0% | 499.52 | 1 ML
ZD-0892 is a selective and potent inhibitor of neutrophil elastase, with Ki values of 6.7 nM for human neutrophil elastase and 200 nM for porcine pancreatic elastase. It is intended for research use only and not for sale to patients. The product is a solid, white to off-white in appearance.
- Selective and potent inhibitor of neutrophil elastase.
- Reduces myocardial elastolytic activity and coronary microvascular perfusion injury in DBA/2 mice infected with the EMC virus.
- Decreases the pathologic severity of myocardial lesions associated with murine viral myocarditis.
- Capable of reversing advanced pulmonary vascular disease in rats.
Medchemexpress LLC ZD 7155 hydrochloride | 146709-78-6 | MFCD00921888 | 99.9% | 475.0 g/mol | C26H27ClN6O | 1 ML
ZD 7155 hydrochloride is a selective, nonpeptide antagonist of the angiotensin II type 1 (AT1) receptor supplied as a 10 mM solution in a 1 mL vial for research use. It blocks AT1-mediated signaling in pharmacology and physiological studies and is provided with batch-specific purity data (COA).
- Selective AT1 receptor antagonist useful for receptor pharmacology studies.
- Supplied as a 10 mM solution for direct use in assays.
- Provided with certificate of analysis and batch purity information.
- Available in multiple pack sizes for assay scale flexibility.
Apexbio Technology LLC ZD 7288(Synonyms: ZD7288, Zatebradine hydrochloride, HCN channel inhibitor ZD7288), 25mg, CAS: 133059-99-1.
ZD 7288 (CAS 133059-99-1) is a selective inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels These channels mediate Na and K currents notably the hyperpolarization-activated current (I h) contributing to neuronal excitability and rhythmic activity ZD 7288 reduces I h in a concentration-dependent voltage- and time-sensitive manner as demonstrated in rat facial motoneurons (IC 50 0 2 M) and hippocampal CA1 pyramidal neurons Additionally it inhibits T-type calcium currents in rat CA1 pyramidal cells ZD 7288 is utilized in research investigating neuronal excitability mechanisms pain signaling and chronic visceral pain models
Apexbio Technology LLC ZD 7288(Synonyms: ZD7288, Zatebradine hydrochloride, HCN channel inhibitor ZD7288), 10mg, CAS: 133059-99-1.
ZD 7288 (CAS 133059-99-1) is a selective inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels These channels mediate Na and K currents notably the hyperpolarization-activated current (I h) contributing to neuronal excitability and rhythmic activity ZD 7288 reduces I h in a concentration-dependent voltage- and time-sensitive manner as demonstrated in rat facial motoneurons (IC 50 0 2 M) and hippocampal CA1 pyramidal neurons Additionally it inhibits T-type calcium currents in rat CA1 pyramidal cells ZD 7288 is utilized in research investigating neuronal excitability mechanisms pain signaling and chronic visceral pain models
Cayman Chemical ZD 7155hydrochlorIde 1mg
An AT1 receptor antagonist (IC50 = 3.3 nM); inhibits angiotensin II-induced pressor responses in conscious normotensive rats; decreases mean arterial pressure in conscious spontaneously hypertensive rats at 1.082 µmol/kg; improves motor nerve conduction velocity in the sciatic nerve in a rat model of streptozotocin-induced diabetic neuropathy at 10 mg/kg in the drinking water; decreases disease severity and NF-κB and AP-1 activation in a mouse model of LPS-induced acute lung injury at 10 mg/kg
Cayman Chemical ZD 7155hydrochlorIde 5mg
An AT1 receptor antagonist (IC50 = 3.3 nM); inhibits angiotensin II-induced pressor responses in conscious normotensive rats; decreases mean arterial pressure in conscious spontaneously hypertensive rats at 1.082 µmol/kg; improves motor nerve conduction velocity in the sciatic nerve in a rat model of streptozotocin-induced diabetic neuropathy at 10 mg/kg in the drinking water; decreases disease severity and NF-κB and AP-1 activation in a mouse model of LPS-induced acute lung injury at 10 mg/kg
Cayman Chemical ZD 7155hydrochlorIde 25mg
An AT1 receptor antagonist (IC50 = 3.3 nM); inhibits angiotensin II-induced pressor responses in conscious normotensive rats; decreases mean arterial pressure in conscious spontaneously hypertensive rats at 1.082 µmol/kg; improves motor nerve conduction velocity in the sciatic nerve in a rat model of streptozotocin-induced diabetic neuropathy at 10 mg/kg in the drinking water; decreases disease severity and NF-κB and AP-1 activation in a mouse model of LPS-induced acute lung injury at 10 mg/kg
TARGETMOL CHEMICALS INC ZD 7155 HYDROCHLORIDE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist. purity: 99%