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Thomas Scientific 100ml Accuflow Reagent Reservoir Individually Wrapped Ster
100ml Accuflow Reagent Reservoir Individually Wrapped Ster
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Thomas Scientific 100ml Accuflow Reagent Reservoir Bulk Packaged Sterile
100ml Accuflow Reagent Reservoir Bulk Packaged Sterile
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Medchemexpress LLC Ars-853 | 1629268-00-3 | 98.39% | 432.94 | 50 MG
ARS-853 is a cell-active, selective, covalent KRAS G12C inhibitor with an IC50 of 2.5 μM. It inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein, thereby preventing its activation.
- Cell-active, selective, covalent KRAS G12C inhibitor.
- Inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation.
- Reduces the level of GTP-bound KRAS by more than 95% (at 10 μM) in KRASG12C-mutant lung cancer cells.
- Inhibits proliferation with an IC50 of 2.5 μM.
- Selectively reduces KRAS-GTP levels and RAS-effector signaling in KRASG12C-mutant cells.
- Induces apoptosis in four KRASG12C mutant cell lines.
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Selleck Chemical LLC ARS-853
ARS-853 is a selective covalent KRAS(G12C) inhibitor that inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation ARS-853 also induces apoptosis
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Selleck Chemical LLC ARS-853
ARS-853 is a selective covalent KRAS(G12C) inhibitor that inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation ARS-853 also induces apoptosis
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