Process Flow Controllers
Medchemexpress LLC ARS-853 | 1629268-00-3 | 98.39% | 432.94 | 500 MG
ARS-853 is a cell-active, selective, covalent KRAS G12C inhibitor. It inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein, thereby preventing its activation. This compound is intended for research use only.
- Cell-active and selective KRAS G12C inhibitor.
- Inhibits mutant KRAS-driven signaling.
- Prevents activation of GDP-bound oncoprotein.
- Reduces GTP-bound KRAS levels by more than 95% at 10 μM in KRASG12C-mutant lung cancer cells.
- Inhibits proliferation, effector signaling, and induces apoptosis in KRASG12C mutant cell lines.
Medchemexpress LLC ARS-853 | 1629268-00-3 | 98.39% | 432.94 | 25 MG
ARS-853 is a cell-active, selective, and covalent KRAS G12C inhibitor with an IC50 of 2.5 μM. It inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein, thereby preventing its activation.
- Selective KRAS G12C inhibition: designed to bind to KRASG12C with high affinity.
- Potent cellular activity: reduces GTP-bound KRAS levels by over 95% at 10 μM in KRASG12C-mutant lung cancer cells.
- Antiproliferative effects: inhibits proliferation in KRASG12C mutant lung cancer cell lines with an IC50 of 2.5 μM.
- Induces apoptosis in four KRASG12C mutant cell lines.
- Suppresses effector signaling: completely suppresses the effects of exogenous KRASG12C expression on KRAS-GTP levels, KRAS-BRAF interaction, and ERK signaling.
- Intended for research use only.
Medchemexpress LLC Ars-853 | 1629268-00-3 | 98.39% | 432.94 | 1 ML
ARS-853 is a cell-active, selective, covalent KRAS G12C inhibitor with an IC50 of 2.5 μM. It inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation.
- Cell-active, selective, covalent KRAS G12C inhibitor.
- IC50 of 2.5 μM for KRAS(G12C).
- Inhibits mutant KRAS-driven signaling.
- Reduces GTP-bound KRAS levels by more than 95% at 10 μM in KRASG12C-mutant lung cancer cells.
- Inhibits proliferation with an IC50 similar to its target inhibition IC50.
- Selectively reduces KRAS-GTP levels and RAS-effector signaling in KRASG12C-mutant cells.
- Induces apoptosis in four KRASG12C mutant cell lines.
AVANTOR MASTERFLEX (VWR LLC) Masterflex Variable-Area Flowmeter with Valve, Direct Reading, Aluminum Fittings, 65-mm Scale; 2 LPM Air
This full range of direct-reading flowmeters provide a robust solution for your laboratory that eliminates the need for reading conversions. Valved flowmeters have a valve mounted at the inlet (bottom) of the flowmeter. This arrangement is typically used for positive pressure applications for liquids and gases. The valve can be reconfigured to mount at the outlet (top), often for vacuum applications.
Cole-Parmer Diba Omnifit Standard Valve for 1 to 4 mm OD Tubing, 3-way, tee, single key; 1/ea
Quickly and easily connect semi-rigid tubing such as PTFE, ETFE, and FEP as well as rigid materials such as glass, PEEK, and stainless steel. Use the interchangeable components to create chemically inert fluid pathway connections and flat-bottom ports (using Gripper fittings). Fittings are autoclavable (remove caps first). Order colored caps quickly and easily color code multiple fluid lines.
AVANTOR MASTERFLEX (VWR LLC) Masterflex Variable-Area Flowmeter with High-Res Valve, Correlated Reading, PTFE Housing and Fittings, 65-mm Scale; 29,218 mL/min Air
The substitution of metal fittings with PTFE eliminates a potential contamination source for high-purity applications. The glass tube utilizes a fused ceramic scale for a precise, permanent measuring guide. In addition, a vertical-tangential locator line provides readings with hairline accuracy. Further improving readability is a front shield that magnifies the scale 16%. An anodized aluminum frame protects the heavy-walled glass flowtube; a white acrylic backplate protects and enhances viewing in the protective frame.
Select a flowmeter with a valve for flow rate control. The standard valve is suitable where high resolution metering is not essential. The high precision valve features a fine-adjust 16-turn "non-rising stem" to more accurately set your desired flow rate.
All flowmeters come with correlation data sheets for water and numerous gases (listed below) at standard temperature and pressure (STP).
AVANTOR MASTERFLEX (VWR LLC) Masterflex Variable-Area Flowmeter with High-Res Valve, Correlated Reading, High-Flow, Aluminum Housing and Fittings, 150-mm Scale; 45.227 LPM Air
Aluminum is economical and good for general use with noncorrosive gases and liquids. Brass is economical and good for use with water. Stainless steel withstands higher temperature and pressure and features excellent chemical compatibility. Valved meters have valves mounted at the bottom/inlet, typically used for positive pressure with liquids and gases. The valve can be reconfigured to mount at the top/outlet, often for vacuum applications. All correlated flowmeters come with data sheets for water and air at standard temperature and pressure (STP).
AVANTOR MASTERFLEX (VWR LLC) Masterflex Variable-Area Flowmeter with High-Res Valve, Correlated Reading, Aluminum Housing and Fittings, 150-mm Scale; 4562 mL/min Air
Aluminum is economical and good for general use with noncorrosive gases and liquids. Brass is economical and good for use with water. Stainless steel withstands higher temperature and pressure and features excellent chemical compatibility. Valved meters have valves mounted at the bottom/inlet, typically used for positive pressure with liquids and gases. The valve can be reconfigured to mount at the top/outlet, often for vacuum applications. All correlated flowmeters come with data sheets for water and air at standard temperature and pressure (STP).