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Medchemexpress LLC ARS-1323 | 1698024-73-5 | 430.84 | 100 MG
ARS-1323 is a potent KRAS G12C inhibitor. It specifically binds to the cysteine residue on the mutant K-Ras protein, locking it in the GDP-bound conformation and effectively blocking K-Ras activation and downstream signaling pathways. This compound is valuable for investigating signal transduction mechanisms and growth characteristics of tumor cells driven by K-Ras G12C.
- KRAS G12C inhibitor
- Specifically binds to the cysteine residue on the mutant K-Ras protein
- Blocks K-Ras activation and downstream signaling pathways
- Useful for investigating signal transduction mechanisms
- Useful for studying growth characteristics of K-Ras G12C driven tumor cells
- Supplied as a white to off-white solid
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Thomas Scientific 100ml Accuflow Reagent Reservoir Bulk Packaged Sterile
100ml Accuflow Reagent Reservoir Bulk Packaged Sterile
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Thomas Scientific 100ml Accuflow Reagent Reservoir Individually Wrapped Ster
100ml Accuflow Reagent Reservoir Individually Wrapped Ster
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HANNAS PHARMACEUTICAL SUPPLY CO INC 10CC LUER LOCK SYRINGE W/ 41IN
NC2607642 10CC LUER LOCK SYRINGE W/ 41IN
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Medchemexpress LLC Ars-853 | 1629268-00-3 | 98.39% | 432.94 | 50 MG
ARS-853 is a cell-active, selective, covalent KRAS G12C inhibitor with an IC50 of 2.5 μM. It inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein, thereby preventing its activation.
- Cell-active, selective, covalent KRAS G12C inhibitor.
- Inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation.
- Reduces the level of GTP-bound KRAS by more than 95% (at 10 μM) in KRASG12C-mutant lung cancer cells.
- Inhibits proliferation with an IC50 of 2.5 μM.
- Selectively reduces KRAS-GTP levels and RAS-effector signaling in KRASG12C-mutant cells.
- Induces apoptosis in four KRASG12C mutant cell lines.