Complex Aldehydes
Apexbio Technology LLC 2-Deoxy-D-glucose 154-17-6 1g
2-Deoxy-D-glucose (2-DG) is a glucose analog that acts as a competitive inhibitor of glycolysis interfering with cellular glucose metabolism and ATP synthesis It suppresses glycolytic flux altering cellular energy levels and inducing metabolic stress In vitro studies demonstrate its cytotoxicity against the KIT-positive gastrointestinal stromal tumor (GIST) cell lines GIST882 and GIST430 with IC50 values of 0 5 M and 2 5 M respectively Additionally treatment with 2-DG impairs viral protein translation during early virus replication stages and can potentiate chemotherapeutic agents cytotoxicity in human cancer models supporting its applicability in metabolic pathway studies and cancer therapy research
Apexbio Technology LLC 2-Deoxy-D-glucose 154-17-6 5g
2-Deoxy-D-glucose (2-DG) is a glucose analog that acts as a competitive inhibitor of glycolysis interfering with cellular glucose metabolism and ATP synthesis It suppresses glycolytic flux altering cellular energy levels and inducing metabolic stress In vitro studies demonstrate its cytotoxicity against the KIT-positive gastrointestinal stromal tumor (GIST) cell lines GIST882 and GIST430 with IC50 values of 0 5 M and 2 5 M respectively Additionally treatment with 2-DG impairs viral protein translation during early virus replication stages and can potentiate chemotherapeutic agents cytotoxicity in human cancer models supporting its applicability in metabolic pathway studies and cancer therapy research
Medchemexpress LLC 2-Deoxy-D-glucose | 154-17-6 | 99.9% | 164.16 | 25 G
2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase.
- Significantly reduces the level of ATP in MCF-7 cells in a dose- and time-dependent manner.
- Decreases phosphorylated Akt levels and increases phosphorylated AMPK and Sirt-1 levels in MCF-7 cells.
- Increases the levels of pentose phosphate pathway (PPP) metabolites and augments the generation of NADPH by glucose-6-phosphate dehydrogenase.
- Increases the reduced form of glutathione by 2-DG in NB4 cells.
- Causes a 7% decrease in final weight and delays the appearance of palpable mammary carcinomas in vivo.
- Decreased in a dose-dependent manner in rat muscle in vivo.
(2E,4E,6E)-2,7-Dimethylocta-2,4,6-trienedial 98.0+%, TCI America™
CAS: 5056-17-7 Molecular Formula: C10H12O2 Molecular Weight (g/mol): 164.204 MDL Number: MFCD11113099 InChI Key: AYODHZHFDRRQEZ-XLKYRCCQSA-N PubChem CID: 6504517 IUPAC Name: (2E,4E,6E)-2,7-dimethylocta-2,4,6-trienedial SMILES: CC(=CC=CC=C(C)C=O)C=O