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Alphitolic acid is an anti-inflammatory triterpene that blocks Akt-NF-κB signaling to induce apoptosis and also induces autophagy. It exhibits anti-inflammatory activity by down-regulating NO and TNF-α production, making it useful for cancer and inflammation research.
Anti-inflammatory triterpene
Induces apoptosis by blocking Akt-NF-κB signaling
Induces autophagy
Down-regulates NO and TNF-α production
Useful for cancer and inflammation research
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Alphitolic acid is an anti-inflammatory triterpene found in Quercus aliena. It induces apoptosis by blocking Akt-NF-κB signaling and also induces autophagy. It exhibits anti-inflammatory activity by down-regulating NO and TNF-α production and is used for cancer and inflammation research.
Anti-inflammatory activity
Induces apoptosis by blocking Akt-NF-κB signaling
Induces autophagy
Down-regulates nitric oxide and TNF-α production
Shows anti-proliferative activity in oral cancer cells
Increases p53 phosphorylation and expression
Decreases expression of the oncogenic E3 ligase MDM2
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Chebulagic acid isolated form Terminalia chebula Retz is a reversible and non-competitive inhibitor of maltase with a Ki value of 6 6 M Chebulagic acid shows potent anti-inflammatory effects in LPS-stimulated RAW 264 7 cells Chebulagic acid also shows potent COX-LOX dual inhibition activity with IC50 values of 15 M 0 92 M and 2 1 M for COX-1 COX-2 and 5-LOX respectively
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More