Oligonucleotides
Biotium CD43 (T-Cell Marker)(SPN/3388), CF405S conjugate, 0.1mg/mL
Recognizes a cell surface glycoprotein of 95/115/135 kDa (depending upon the extent of glycosylation), identified as CD43. 70-90% of T-cell lymphomas and from 22-37% of B-cell lymphomas express CD43. No reactivity has been observed with reactive B-cells. So a B-lineage population that co-expresses CD43 is highly likely to be a malignant lymphoma, especially a low-grade lymphoma, rather than a reactive B-cell population. When CD43 antibody is used in combination with anti-CD20, effective immunophenotyping of the lymphomas in formalin-fixed tissues can be obtained. Co-staining of a lymphoid infiltrate with anti-CD20 and anti-CD43 argues against a reactive process and favors a diagnosis of lymphoma. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targe
ABclonal Technology Phospho-EZH2/KMT6-T311 Rabbit pAb
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.
Cayman Chemical Flos Sopoa matuus Toxutn 100g
A flavonoid with diverse biological activities; reduces D-galactose-induced increases in renal MDA levels and decreases in renal Cu/Zn SOD, catalase, and GPX activities in mice at 150 mg/kg per day, as well as attenuates D-galactose-induced increases in renal levels of NF-κB p65, iNOS, COX-2, and EP2 levels; reduces blood glucose levels, plasma triglyceride levels, heart rate, and blood pressure in a rat model of STZ-induced type 2 diabetes at 150 mg/kg per day; prevents the loss of dopaminergic neurons in the SNC and reduces apomorphine-induced contralateral rotations in a rat model of Parkinson’s disease induced by 6-OHDA at 150 mg/kg per day
Alkali Scientific DNA & RNA Elution Buffer (EB Buffer) for PCR, Plasmid & Spin Column Cleanup, 60mL
DNA and RNA Elution Buffer is designed for efficient recovery of nucleic acids from spin column purification systems and similar workflows. The formulation supports gentle elution of DNA and RNA while preserving their integrity for sensitive downstream applications such as PCR, sequencing, and cloning. It provides a stable environment that minimizes degradation and ensures consistent performance during nucleic acid handling. The buffer is commonly used in plasmid purification, PCR cleanup, and genomic DNA or RNA isolation procedures. Its compatibility with a wide range of molecular biology techniques makes it an essential reagent in research, clinical, and biotechnology laboratories requiring reliable nucleic acid recovery.
ABclonal Technology VHL Rabbit pAb
This gene encodes a component of a ubiquitination complex. The encoded protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. In addition to oxygen-related gene expression, this protein plays a role in many other cellular processes including cilia formation, cytokine signaling, regulation of senescence, and formation of the extracellular matrix. Variants of this gene are associated with von Hippel-Lindau syndrome, pheochromocytoma, erythrocytosis, renal cell carcinoma, and cerebellar hemangioblastoma.
ABclonal Technology AVIL Rabbit pAb
The protein encoded by this gene is a member of the gelsolin/villin family of actin regulatory proteins. This protein has structural similarity to villin. It binds actin and may play a role in the development of neuronal cells that form ganglia.
ABclonal Technology SPOCK3 Rabbit pAb
This gene encodes a member of a novel family of calcium-binding proteoglycan proteins that contain thyroglobulin type-1 and Kazal-like domains. The encoded protein and may play a role in adult T-cell leukemia by inhibiting the activity of membrane-type matrix metalloproteinases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Medchemexpress LLC SPARC Human HEK293 5ug
Recombinant human SPARC (secreted protein acidic and rich in cysteine) produced in HEK293 mammalian cells and supplied as a lyophilized, C-terminal His-tagged protein for biochemical and cell-based studies involving extracellular matrix interactions and lipoprotein binding. Suitable for binding assays, structural studies, and functional assays.
- Expressed in HEK293 mammalian cells for native glycosylation.
- C-terminal 6xHis tag enabling affinity purification and detection.
- Available in multiple sizes down to 5 μg for small-scale experiments.
- Purity greater than 95% by reducing SDS-PAGE.
- Lyophilized formulation with trehalose for stability and long-term storage.
- Includes full sequence corresponding to UniProt residues A18-I303 and glycosylated molecular weight ~37-46 kDa.
Biotium pS2 / pNR-2 / TFF1 (Estrogen-Regulated Protein)(rTFF1/1091), CF594 conjugate, 0.1mg/mL
Recognizes a polypeptide of 6. 5 kDa, identified as pS2 estrogen-regulated protein. Its epitope is located in the c-terminus of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelih
Cayman Chemical ANTIBODY TAK-733 10mg
A MEK1 inhibitor (IC50 = 3.2 nM); inhibits ERK phosphorylation in vitro (EC50 = 1.9 nM); inhibits proliferation of A375 and COLO 205 cells (EC50s = 3.1 and 2.1 nM, respectively) and 14 cutaneous melanoma cell lines (IC50s = V600E mutations
Revvity Health Sciences Inc HTRF Dasatinib Red Ligand, 20 nmoles
HTRF Dasatinib Red Ligand, 20 nmoles
Revvity Health Sciences Inc HTRF Sunitinib Red Ligand, 20 nmoles
HTRF Sunitinib Red Ligand, 20 nmoles
ABclonal Technology Phospho-GRIN2B-Y1474 Rabbit pAb
This gene encodes a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. The encoded protein is a subunit of the NMDA receptor ion channel which acts as an agonist binding site for glutamate. The NMDA receptors mediate a slow calcium-permeable component of excitatory synaptic transmission in the central nervous system. The NMDA receptors are heterotetramers of seven genetically encoded, differentially expressed subunits including NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The early expression of this gene in development suggests a role in brain development, circuit formation, synaptic plasticity, and cellular migration and differentiation. Naturally occurring mutations within this gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia.