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Oligonucleotides with a wide variety of applications in microarrays, gel shift assays, artificial gene synthesis, PCR, DNA sequencing, molecular cloning, and other custom procedures. Available in multiple primer lengths; may be pre-designed or random.
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This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins This highly conserved protein family is found in both plants and mammals and this protein is 99% identical to the mouse rat and sheep orthologs The encoded protein interacts with IRS1 protein suggesting a role in regulating insulin sensitivity Several transcript variants that differ in the 5 UTR but that encode the same protein have been identified for this gene
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A Bax inhibitor; binds to Bax in a cell-free assay (Kd = 15 µM); inhibits tBID-induced Bax-mediated membrane permeabilization in a liposomal release assay (IC50 = 3.3 µM); inhibits TNF-α- and cycloheximide-induced apoptosis in MEFs (IC50 = 1.8 µM); inhibits BTSA1-induced cell death in OCI-AML-3 cells
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An EPA metabolite and activator of KCa1.1/BK channels; increases the potassium current amplitude by 15-fold in isolated rat cerebral artery VSMCs at 50 nM; has negative chronotropic effects in NRCMs (EC50 = ~1-2 nM) and prevents calcium-induced increases in NRCM spontaneous beating
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More