Oligonucleotides
BIOHIPPO AAV-GFAP-Cre-3XFlag-WPRE-hGH-polyA
Recombinant adeno associated virus expressing Cre 3XFlag under the GFAP promoter with WPRE and hGH polyA elements. The Cre dependent configuration enables expression only after recombination, providing precise targeted control of targeted neurons. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.
Medchemexpress LLC Cellular retinoic acid-binding protein 1 (human) | >95.0% | 10 UG
Recombinant human cellular retinoic acid-binding protein 1 (CRABP1), expressed in E. coli and provided tag-free, is supplied for research applications involving retinoic acid signaling, protein interaction studies, and biochemical assays. The purified protein (~14 kDa) is offered in small quantities suitable for binding studies and method development.
- Recombinant human sequence for relevant biological activity.
- Tag free to minimize interference in functional assays.
- Expressed in E. coli for efficient production and consistency.
- Approximate molecular weight 14 kDa for identification and QC.
- Available in small sizes such as 10 μg for low-consumption experiments.
- Purity greater than 95% to support biochemical and binding studies.
Medchemexpress LLC hsa-miR-23a-3p antag 20nmol | 20nmol
hsa-miR-23a-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs The miRNA antagomirs have 2 phosphorothioates at the 5 end 4 phosphorothioates at the 3 end 1 cholesterol group at the 3 end and full-length nucleotide 2 -methoxy modification The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes thereby inhibiting miRNAs from functioning Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors they exhibits enhanced cellular uptake stability and regulatory activity in vivo
Genscript Corporation VEGF R2/KDRBiotin mFc Chimer
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA VEGFB and PGF and plays an essential role in the development of embryonic vasculature the regulation of angiogenesis cell survival cell migration macrophage function chemotaxis and cancer cell invasion The tyrosine kinase receptor vascular endothelial growth factor receptor 2 (VEGFR2) is a key regulator of angiogenesis
BIOHIPPO AAV-CaMKIIa-C1V1-(t/t)-TS-EYFP-WPRE-hGH-polyA
Recombinant adeno associated virus expressing C1V1 (t/t) fused to EYFP under the CaMKIIa promoter with WPRE and hGH polyA elements. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.
New England Biolabs, Inc. NEBNext Enzymatic 5hmC-seq Kit 24 rxns
The NEBNext Enzymatic 5hmC-seq Kit specifically detects 5hmC sites. The kit includes NEBNext Ultra II library prep reagents, and 5hmC is detected using a two-step enzymatic conversion workflow that minimizes damage to DNA and allows discrimination of 5hmC from both cytosine and 5mC after Illumina sequencing. E5hmC-seq data can also be subtracted from EM-seq data, allowing determination of the precise location of individual 5mC and 5hmC sites. The kit includes the E5hmC-seq adaptor and index primers are supplied separately.
New England Biolabs, Inc. N-Glycopeptide Binding Protein - 1 ml
N-Glycopeptide Binding Protein, also known as Fbs1-GYR lectin, is engineered to selectively bind and enrich a wide variety of N-glycopeptides in a complex proteomic sample to assist N-glycoprotein identification and discovery, without requiring the use of traditional lectin affinity chromatography (LAC) techniques, HILIC columns or cartridges. This engineered lectin, originating from human Fbs1 protein, exhibits improved specificity towards high mannose, complex, and hybrid N-glycans, as well as towards fucosylated and non-fucosylated, sialylated and non-sialylated, with bi-, tri- and tetra-antennary structures. N-Glycopeptide Binding Protein includes a SNAP tag for immobilizing to create versatile workflows. 1 mL of protein at 1 mg/mL Source: An E. coli strain that carries human Fbs1 mutant gene. Storage Buffer: 20 mM Tris-HCl, 50 mM NaCl, 0.2 mM TCEP, pH 8.0 Heat Inactivation: No
Biotium CD43 (T-Cell Marker) (rSPN/1094), CF740 conjugate, 0.1mg/mL
This antibody recognizes a cell surface glycoprotein of 95/115/135 kDa (depending upon the extent of glycosylation), identified as CD43. 70-90% of T-cell lymphomas and from 22-37% of B-cell lymphomas express CD43. No reactivity has been observed with reactive B-cells. So a B-lineage population that co-expresses CD43 is highly likely to be a malignant lymphoma, especially a low-grade lymphoma, rather than a reactive B-cell population. When CD43 antibody is used in combination with anti-CD20, effective immunophenotyping of lymphomas in formalin-fixed tissues can be obtained. Co-staining of a lymphoid infiltrate with anti-CD20 and anti-CD43 argues against a reactive process and favors a diagnosis of lymphoma.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low ab
Cayman Chemical ComasIe Blue R-250 25g
A dye that is commonly used in laboratories to stain or quantify proteins; typically gives blue bands on a clear background with a sensitivity of 50-100 ng/band; displays metachromasia by appearing pink-red, rather than blue, when binding certain proteins, such as collagen and histone H1
Biotium pS2(TFF1/1091), CF488A conjugate, 0.1mg/mL
This antibody recognizes a polypeptide of 6.5 kDa, identified as pS2 estrogen-regulated protein. Its epitope is located in the c-terminus of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased
Vector Biolabs Tamoxifen inducible Cre (CreERT2-mCherry) Adenovirus (Ad-mCherry-CreERT2)
Ready to use in vivo grade AAV and Adenovirus Ready to use in vivo grade AAV and Adenovirus pre synthesized DNA vector High titer viral vectors 1/EA
Meso Scale Discovery U-PLEX Human vWF ASYQP
The Meso Scale Discovery U-PLEX Human VWF Assay is an electrochemiluminescent immunoassay for the quantitative measurement of von Willebrand Factor (VWF) in human serum plasma and cell culture supernatants This assay utilizes MSD s proprietary SULFO-TAG labels and multi-array technology to provide sensitive and reproducible quantitation of VWF with a wide dynamic range The assay requires a small sample volume and has a total assay time of approximately 3 5 hours The lower limit of detection is 1 3 ng/mL and the upper limit of quantitation is 10 000 ng/mL This assay provides a simple rapid high-throughput method for measuring VWF levels
Biotium pS2 / pNR-2 / TFF1 (Estrogen-Regulated Protein)(rTFF1/1091), CF740 conjugate, 0.1mg/mL
Recognizes a polypeptide of 6. 5 kDa, identified as pS2 estrogen-regulated protein. Its epitope is located in the c-terminus of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelih
Cayman Chemical VHL LIgnd 1hydrochlorIde 25mg
A PROTAC building block; VHL E3 binding portion of BET PROTAC MZ1
BIOHIPPO AAV-RAM-rtTA-TRE-tight-Cre-EGFP-WPRE-bGH-polyA
Recombinant adeno associated virus expressing rtTA Cre fused to EGFP under the RAM TRE tight promoter with WPRE and hGH polyA elements. The Tet responsive configuration enables doxycycline controlled expression, providing precise targeted control of targeted neurons. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.